Scavenging nucleic acid debris to combat autoimmunity and infectious disease

Autoantibodies in systemic autoimmune diseases: specificity and pathogenicity

(2015) Jolien Suurmond et al.   JOURNAL OF CLINICAL INVESTIGATION

B Cell–Specific MHC Class II Deletion Reveals Multiple Nonredundant Roles for B Cell Antigen Presentation in Murine Lupus

(2015) Josephine R. Giles et al.   JOURNAL OF IMMUNOLOGY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Therapeutics to block autoantibody initiation and propagation in systemic lupus erythematosus and rheumatoid arthritis

(2015) Jolien Suurmond et al.   Science Translational Medicine

Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese population

(2014) Chin-Man Wang et al.   Scientific Reports

A novel antagonist of Toll-like receptors 7, 8 and 9 suppresses lupus disease-associated parameters in NZBW/F1 mice

(2013) Fu-Gang Zhu et al.   AUTOIMMUNITY

Platelets and autoimmunity

(2013) Kim L. L. Habets et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Distinct Autoantibody Profiles in Systemic Lupus Erythematosus Patients are Selectively Associated with TLR7 and TLR9 Upregulation

(2013) Sudhir Kumar Chauhan et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Increased Ribonuclease Expression Reduces Inflammation and Prolongs Survival in TLR7 Transgenic Mice

(2013) X. Sun et al.   JOURNAL OF IMMUNOLOGY

A Toll-Like Receptor 7, 8, and 9 Antagonist Inhibits Th1 and Th17 Responses and Inflammasome Activation in a Model of IL-23-Induced Psoriasis

(2013) Weiwen Jiang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Systemic lupus erythematosus and other autoimmune rheumatic diseases: challenges to treatment

(2013) Grainne Murphy et al.   LANCET

Rituximab in the treatment of resistant lupus nephritis: therapy failure in rapidly progressive crescentic lupus nephritis

(2013) RJ Davies et al.   LUPUS

Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9

(2013) Ekambar R. Kandimalla et al.   NUCLEIC ACIDS RESEARCH

Nucleic Acid Scavenging Polymers Inhibit Extracellular DNA-Mediated Innate Immune Activation without Inhibiting Anti-Viral Responses

(2013) Eda K. Holl et al.   PLoS One

MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus

(2013) Yun Deng et al.   PLoS Genetics

TLR7 and TLR9 in SLE: when sensing self goes wrong

(2012) T. Celhar et al.   IMMUNOLOGIC RESEARCH

Platelets: active players in the pathogenesis of arthritis and SLE

(2012) Eric Boilard et al.   Nature Reviews Rheumatology

The Inhibition of Anti-DNA Binding to DNA by Nucleic Acid Binding Polymers

(2012) Nancy A. Stearns et al.   PLoS One

Nucleic acid scavengers inhibit thrombosis without increasing bleeding

(2012) S. Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivery of subunit influenza vaccine to skin with microneedles improves immunogenicity and long-lived protection

(2012) Dimitrios G. Koutsonanos et al.   Scientific Reports

IL-2, IL-5, TNF-α and IFN-γ mRNA expression in epidermal keratinocytes of systemic lupus erythematosus skin lesions

(2011) José Ronaldo M Carneiro et al.   Clinics

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines

(2011) A. Kuznik et al.   JOURNAL OF IMMUNOLOGY

Interferon Alpha as a Primary Pathogenic Factor in Human Lupus

(2011) Timothy B. Niewold   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Nucleic acid-binding polymers as anti-inflammatory agents

(2011) J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon regulatory factors in human lupus pathogenesis

(2011) Rafah Salloum et al.   Translational Research

TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study

(2011) Aya Kawasaki et al.   ARTHRITIS RESEARCH & THERAPY

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY

Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9

(2010) Cristiana Guiducci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR9 Regulates TLR7- and MyD88-Dependent Autoantibody Production and Disease in a Murine Model of Lupus

(2010) Kevin M. Nickerson et al.   JOURNAL OF IMMUNOLOGY

Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus

(2010) N. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The management of peripheral blood cytopenias in systemic lupus erythematosus

(2010) A. L. Hepburn et al.   RHEUMATOLOGY

Inflammasomes and autoimmunity

(2010) Patrick J. Shaw et al.   TRENDS IN MOLECULAR MEDICINE

Activation of the interferon-γ signaling pathway in systemic lupus erythematosus peripheral blood mononuclear cells

(2009) Thomas Karonitsch et al.   ARTHRITIS AND RHEUMATISM

Toll-like receptors and innate immunity

(2009) Himanshu Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Development of TLR inhibitors for the treatment of autoimmune diseases

(2008) Franck J. Barrat et al.   IMMUNOLOGICAL REVIEWS

IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice

(2008) Haoli Jin et al.   JOURNAL OF CLINICAL INVESTIGATION