Concise Review: Metabolism and Gut Microbiota in Cancer Immunoediting, CD8/Treg Ratios, Immune Cell Homeostasis, and Cancer (Immuno)Therapy

Separating host and microbiome contributions to drug pharmacokinetics and toxicity

(2019) Michael Zimmermann et al.   SCIENCE

Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies

(2019) Chrysovalantis Voutouri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of regulatory T cells in the response to radiation therapy in head and neck cancer

(2019) Ayman J Oweida et al.   JNCI-Journal of the National Cancer Institute

Unraveling the Complex Interplay Between T Cell Metabolism and Function

(2018) Ramon I. Klein Geltink et al.   Annual Review of Immunology

The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy

(2018) Vancheswaran Gopalakrishnan et al.   CANCER CELL

Immunogenic chemotherapy: Dose and schedule dependence and combination with immunotherapy

(2018) Junjie Wu et al.   CANCER LETTERS

The Immune Landscape of Cancer

(2018) Vésteinn Thorsson et al.   IMMUNITY

Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy

(2018) Jinyang Li et al.   IMMUNITY

How to mathematically optimize drug regimens using optimal control

(2018) Helen Moore   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Immune modulatory effects of radiotherapy as basis for well-reasoned radioimmunotherapies

(2018) Michael Rückert et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

(2018) Marc O. Johnson et al.   CELL

Immune recognition of irradiated cancer cells

(2017) Erik Wennerberg et al.   IMMUNOLOGICAL REVIEWS

Immunomodulation by ionizing radiation-impact for design of radio-immunotherapies and for treatment of inflammatory diseases

(2017) Benjamin Frey et al.   IMMUNOLOGICAL REVIEWS

A Combination of Immune Checkpoint Inhibition with Metronomic Chemotherapy as a Way of Targeting Therapy-Resistant Cancer Cells

(2017) Irina Kareva   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stereotactic Radiotherapy Increases Functionally Suppressive Regulatory T Cells in the Tumor Microenvironment

(2017) Yuki Muroyama et al.   Cancer Immunology Research

Concurrent PD-1 Blockade Negates the Effects of OX40 Agonist Antibody in Combination Immunotherapy through Inducing T-cell Apoptosis

(2017) Rajeev K. Shrimali et al.   Cancer Immunology Research

Immune suppressive mechanisms in the tumor microenvironment

(2016) David H Munn et al.   CURRENT OPINION IN IMMUNOLOGY

Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing

(2016) Audrey Nosbaum et al.   JOURNAL OF IMMUNOLOGY

A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment

(2016) Akio Ohta   Frontiers in Immunology

The ratio of CD8 to Treg tumor-infiltrating lymphocytes is associated with response to cisplatin-based neoadjuvant chemotherapy in patients with muscle invasive urothelial carcinoma of the bladder

(2016) Alexander S. Baras et al.   OncoImmunology

Normal Wound Healing and Tumor Angiogenesis as a Game of Competitive Inhibition

(2016) Irina Kareva et al.   PLoS One

Metronomic chemotherapy: An attractive alternative to maximum tolerated dose therapy that can activate anti-tumor immunity and minimize therapeutic resistance

(2015) Irina Kareva et al.   CANCER LETTERS

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy

(2015) Shari Pilon-Thomas et al.   CANCER RESEARCH

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Lactate promotes glutamine uptake and metabolism in oxidative cancer cells

(2015) Jhudit Pérez-Escuredo et al.   CELL CYCLE

Effects of extracellular pH and hypoxia on the function and development of antigen-specific cytotoxic T lymphocytes

(2015) Yohko Nakagawa et al.   IMMUNOLOGY LETTERS

From mice to humans: developments in cancer immunoediting

(2015) Michele W.L. Teng et al.   JOURNAL OF CLINICAL INVESTIGATION

Immune evasion through competitive inhibition: The shielding effect of cancer non-stem cells

(2015) Irina Kareva   JOURNAL OF THEORETICAL BIOLOGY

Cancer immunoediting: A process driven by metabolic competition as a predator–prey–shared resource type model

(2015) Irina Kareva et al.   JOURNAL OF THEORETICAL BIOLOGY

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

(2015) Christina Twyman-Saint Victor et al.   NATURE

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy

(2015) A. Sivan et al.   SCIENCE

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

(2015) M. Vetizou et al.   SCIENCE

Ecology meets cancer biology: the cancer swamp promotes the lethal cancer phenotype

(2015) Sarah R. Amend et al.   Oncotarget

Gene expression signatures of breast cancer stem and progenitor cells do not exhibit features of Warburg metabolism

(2015) Nicole Gordon et al.   Stem Cell Research & Therapy

Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions

(2015) Robert Haas et al.   PLOS BIOLOGY

Tumors: Wounds That Do Not Heal--Redux

(2015) H. F. Dvorak   Cancer Immunology Research

Metronomic cyclophosphamide eradicates large implanted GL261 gliomas by activating antitumor Cd8+T-cell responses and immune memory

(2015) Junjie Wu et al.   OncoImmunology

Trial Watch: Immunogenic cell death inducers for anticancer chemotherapy

(2015) Jonathan Pol et al.   OncoImmunology

Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation

(2015) Anna Pastò et al.   Oncotarget

Intermittent Metronomic Drug Schedule Is Essential for Activating Antitumor Innate Immunity and Tumor Xenograft Regression

(2015) Chong-Sheng Chen et al.   NEOPLASIA

Metronomic cyclophosphamide schedule-dependence of innate immune cell recruitment and tumor regression in an implanted glioma model

(2014) Junjie Wu et al.   CANCER LETTERS

Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation

(2014) Mako Nakaya et al.   IMMUNITY

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Tackling the cancer stem cells — what challenges do they pose?

(2014) Diwakar R. Pattabiraman et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting Unique Metabolic Properties of Breast Tumor Initiating Cells

(2014) Weiguo Feng et al.   STEM CELLS

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Immune-suppressive properties of the tumor microenvironment

(2013) Jürgen C. Becker et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer

(2013) L Bracci et al.   CELL DEATH AND DIFFERENTIATION

Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis

(2013) Y. Touil et al.   CLINICAL CANCER RESEARCH

Metabolic control of the Treg/Th17 axis

(2013) Joseph Barbi et al.   IMMUNOLOGICAL REVIEWS

The Ratios of CD8+ T Cells to CD4+CD25+ FOXP3+ and FOXP3- T Cells Correlate with Poor Clinical Outcome in Human Serous Ovarian Cancer

(2013) Claudia C. Preston et al.   PLoS One

Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment

(2013) N. Iida et al.   SCIENCE

The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide

(2013) S. Viaud et al.   SCIENCE

Radiation as an Immune Modulator

(2013) Byron Burnette et al.   SEMINARS IN RADIATION ONCOLOGY

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty

(2012) Jeffrey A. Magee et al.   CANCER CELL

HER2-Associated Radioresistance of Breast Cancer Stem Cells Isolated from HER2-Negative Breast Cancer Cells

(2012) N. Duru et al.   CLINICAL CANCER RESEARCH

The effect of ionizing radiation on the homeostasis and functional integrity of murine splenic regulatory T cells

(2012) Andrea Balogh et al.   INFLAMMATION RESEARCH

Intratumoral Expression of IL-17 and Its Prognostic Role in Gastric Adenocarcinoma Patients

(2012) Ju-gao Chen et al.   International Journal of Biological Sciences

Biomechanical Forces Shape the Tumor Microenvironment

(2011) Adrian C. Shieh   ANNALS OF BIOMEDICAL ENGINEERING

CD8+ cytotoxic T cell and FOXP3+ regulatory T cell infiltration in relation to breast cancer survival and molecular subtypes

(2011) Fangfang Liu et al.   BREAST CANCER RESEARCH AND TREATMENT

Clinical Impact of Different Classes of Infiltrating T Cytotoxic and Helper Cells (Th1, Th2, Treg, Th17) in Patients with Colorectal Cancer

(2011) Marie Tosolini et al.   CANCER RESEARCH

A reversed CD4/CD8 ratio of tumor-infiltrating lymphocytes and a high percentage of CD4+FOXP3+ regulatory T cells are significantly associated with clinical outcome in squamous cell carcinoma of the cervix

(2011) Walayat Shah et al.   Cellular & Molecular Immunology

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

(2011) Peter Carmeliet et al.   NATURE REVIEWS DRUG DISCOVERY

The Accumulation and Prognosis Value of Tumor Infiltrating IL-17 Producing Cells in Esophageal Squamous Cell Carcinoma

(2011) Lin Lv et al.   PLoS One

Mechanical compression drives cancer cells toward invasive phenotype

(2011) J. M. Tse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic state of glioma stem cells and nontumorigenic cells

(2011) E. Vlashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth

(2010) Alexander Roesch et al.   CELL

2-Gy whole-body irradiation significantly alters the balance of CD4+CD25−T effector cells and CD4+CD25+Foxp3+T regulatory cells in mice

(2010) Yanyan Qu et al.   Cellular & Molecular Immunology

Enhancement of antitumor immunity by low-dose total body irradiationis associated with selectively decreasing the proportion and number of T regulatorycells

(2010) Rongjun Liu et al.   Cellular & Molecular Immunology

Selective Changes in the Immune Profile of Tumor-Draining Lymph Nodes After Different Neoadjuvant Chemoradiation Regimens for Locally Advanced Cervical Cancer

(2010) Alessandra Battaglia et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Radiation Enhances Regulatory T Cell Representation

(2010) Evelyn L. Kachikwu et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Metronomic chemotherapy: new rationale for new directions

(2010) Eddy Pasquier et al.   Nature Reviews Clinical Oncology

Gamma irradiation alters the phenotype and function of CD4+CD25+ regulatory T cells

(2009) Mengde Cao et al.   CELL BIOLOGY INTERNATIONAL

Regulatory T cells: how do they suppress immune responses?

(2009) S. Sakaguchi et al.   INTERNATIONAL IMMUNOLOGY

Increased IL-17-producing cells correlate with poor survival and lymphangiogenesis in NSCLC patients

(2009) Xi Chen et al.   LUNG CANCER

Gamma-Ray Resistance of Regulatory CD4+CD25+Foxp3+T Cells in Mice

(2009) Yanyan Qu et al.   RADIATION RESEARCH

Tumor-Infiltrating FOXP3+ T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer

(2008) Paul Salama et al.   JOURNAL OF CLINICAL ONCOLOGY

Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival

(2008) Nancie J. MacIver et al.   JOURNAL OF LEUKOCYTE BIOLOGY