Immune modulatory effects of radiotherapy as basis for well-reasoned radioimmunotherapies

New checkpoints in cancer immunotherapy

(2017) Ling Ni et al.   IMMUNOLOGICAL REVIEWS

Immunomodulation by ionizing radiation-impact for design of radio-immunotherapies and for treatment of inflammatory diseases

(2017) Benjamin Frey et al.   IMMUNOLOGICAL REVIEWS

Current strategies to improve the safety of chimeric antigen receptor (CAR) modified T cells

(2017) Qi-Yu Yang et al.   IMMUNOLOGY LETTERS

Heat shock protein 70 and tumor-infiltrating NK cells as prognostic indicators for patients with squamous cell carcinoma of the head and neck after radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Gro

(2017) Stefan Stangl et al.   INTERNATIONAL JOURNAL OF CANCER

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

(2017) Ugur Sahin et al.   NATURE

Radiotherapy and immunotherapy: a beneficial liaison?

(2017) Ralph R. Weichselbaum et al.   Nature Reviews Clinical Oncology

Recent Developments in Radiotherapy

(2017) Deborah E. Citrin   NEW ENGLAND JOURNAL OF MEDICINE

Biology of high single doses of IORT: RBE, 5 R’s, and other biological aspects

(2017) Carsten Herskind et al.   Radiation Oncology

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

Effects of definitive and salvage radiotherapy on the distribution of lymphocyte subpopulations in prostate cancer patients

(2017) Eva K. Sage et al.   STRAHLENTHERAPIE UND ONKOLOGIE

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

(2017) Claire Vanpouille-Box et al.   Nature Communications

Basics of Radiation Biology When Treating Hyperproliferative Benign Diseases

(2017) Franz Rödel et al.   Frontiers in Immunology

Decrease of Markers Related to Bone Erosion in Serum of Patients with Musculoskeletal Disorders after Serial Low-Dose Radon Spa Therapy

(2017) Aljona Cucu et al.   Frontiers in Immunology

Barriers to Radiation-Induced In Situ Tumor Vaccination

(2017) Erik Wennerberg et al.   Frontiers in Immunology

Modulating Both Tumor Cell Death and Innate Immunity Is Essential for Improving Radiation Therapy Effectiveness

(2017) Qiuji Wu et al.   Frontiers in Immunology

Hypofractionated Irradiation Has Immune Stimulatory Potential and Induces a Timely Restricted Infiltration of Immune Cells in Colon Cancer Tumors

(2017) Benjamin Frey et al.   Frontiers in Immunology

Modulations in the Peripheral Immune System of Glioblastoma Patient Is Connected to Therapy and Tumor Progression—A Case Report from the IMMO-GLIO-01 Trial

(2017) Paul F. Rühle et al.   Frontiers in Neurology

Trial Watch: Adoptively transferred cells for anticancer immunotherapy

(2017) Carole Fournier et al.   OncoImmunology

Tumor-targeted IL-12 combined with local irradiation leads to systemic tumor control via abscopal effects in vivo

(2017) Franziska Eckert et al.   OncoImmunology

Impact of (chemo)radiotherapy on immune cell composition and function in cervical cancer patients

(2017) H. van Meir et al.   OncoImmunology

Checkpoint Antibodies but not T Cell-Recruiting Diabodies Effectively Synergize with TIL-Inducing  -Irradiation

(2016) M. Hettich et al.   CANCER RESEARCH

Systematic review of case reports on the abscopal effect

(2016) Yazan Abuodeh et al.   CURRENT PROBLEMS IN CANCER

Radiation-induced autophagy promotes esophageal squamous cell carcinoma cell survival via the LKB1 pathway

(2016) CHI LU et al.   ONCOLOGY REPORTS

Chemoradiation Increases PD-L1 Expression in Certain Melanoma and Glioblastoma Cells

(2016) Anja Derer et al.   Frontiers in Immunology

Current clinical trials testing the combination of immunotherapy with radiotherapy

(2016) Josephine Kang et al.   Journal for ImmunoTherapy of Cancer

Modern Radiotherapy Concepts and the Impact of Radiation on Immune Activation

(2016) Lisa Deloch et al.   Frontiers in Oncology

Prognostic and predictive value of immunological parameters for chemoradioimmunotherapy in patients with pancreatic adenocarcinoma

(2015) S Karakhanova et al.   BRITISH JOURNAL OF CANCER

Immune-modulating properties of ionizing radiation: rationale for the treatment of cancer by combination radiotherapy and immune checkpoint inhibitors

(2015) Anja Derer et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Modulation of inflammation by low and high doses of ionizing radiation: Implications for benign and malign diseases

(2015) Benjamin Frey et al.   CANCER LETTERS

Synergistic antitumor effects of radiation and proteasome inhibitor treatment in pancreatic cancer through the induction of autophagy and the downregulation of TRAF6

(2015) Hui-Wen Chiu et al.   CANCER LETTERS

High dose bystander effects in spatially fractionated radiation therapy

(2015) Rajalakshmi Asur et al.   CANCER LETTERS

TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity

(2015) Claire Vanpouille-Box et al.   CANCER RESEARCH

Radio-immunotherapy: the focused beam expands

(2015) Benjamin Frey et al.   LANCET ONCOLOGY

Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial

(2015) Encouse B Golden et al.   LANCET ONCOLOGY

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

(2015) Christina Twyman-Saint Victor et al.   NATURE

Impact of fractionation on out-of-field survival and DNA damage responses following exposure to intensity modulated radiation fields

(2015) Mihaela Ghita et al.   PHYSICS IN MEDICINE AND BIOLOGY

STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity

(2015) Olivier Demaria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Radiotherapy for benign achillodynia

(2015) Oliver J. Ott et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Primary glioblastoma multiforme tumors and recurrence

(2015) Carolin Muth et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Study of the anti-inflammatory effects of low-dose radiation

(2015) Martin Large et al.   STRAHLENTHERAPIE UND ONKOLOGIE

In situ vaccination by radiotherapy to improve responses to anti-CTLA-4 treatment

(2015) Claire Vanpouille-Box et al.   VACCINE

Modulation of radiochemoimmunotherapy-induced B16 melanoma cell death by the pan-caspase inhibitor zVAD-fmk induces anti-tumor immunity in a HMGB1-, nucleotide- and T-cell-dependent manner

(2015) N Werthmöller et al.   Cell Death & Disease

Radio-Immunotherapy-Induced Immunogenic Cancer Cells as Basis for Induction of Systemic Anti-Tumor Immune Responses – Pre-Clinical Evidence and Ongoing Clinical Applications

(2015) Anja Derer et al.   Frontiers in Immunology

Heat Shock Protein 70 (Hsp70) Peptide Activated Natural Killer (NK) Cells for the Treatment of Patients with Non-Small Cell Lung Cancer (NSCLC) after Radiochemotherapy (RCTx) – From Preclinical Studies to a Clinical Phase II Trial

(2015) Hanno M. Specht et al.   Frontiers in Immunology

Acquired Resistance to Fractionated Radiotherapy Can Be Overcome by Concurrent PD-L1 Blockade

(2014) S. J. Dovedi et al.   CANCER RESEARCH

Low and moderate doses of ionizing radiation up to 2 Gy modulate transmigration and chemotaxis of activated macrophages, provoke an anti-inflammatory cytokine milieu, but do not impact upon viability and phagocytic function

(2014) R. Wunderlich et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The PD-1/PD-L1 pathway: biological background and clinical relevance of an emerging treatment target in immunotherapy

(2014) Simone Muenst et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Kill and spread the word: stimulation of antitumor immune responses in the context of radiotherapy

(2014) Udo S Gaipl et al.   Immunotherapy

Irradiation and anti–PD-L1 treatment synergistically promote antitumor immunity in mice

(2014) Liufu Deng et al.   JOURNAL OF CLINICAL INVESTIGATION

The Erlangen Dose Optimization trial for low-dose radiotherapy of benign painful elbow syndrome

(2014) O.J. Ott et al.   STRAHLENTHERAPIE UND ONKOLOGIE

The Erlangen Dose Optimization Trial for radiotherapy of benign painful shoulder syndrome

(2014) O.J. Ott et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Radiotherapy for benign calcaneodynia

(2014) Oliver J. Ott et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Sinister Self-Sacrifice: The Contribution of Apoptosis to Malignancy

(2014) Jorine J. L. P. Willems et al.   Frontiers in Immunology

Consensus guidelines for the detection of immunogenic cell death

(2014) Oliver Kepp et al.   OncoImmunology

Low-Dose Irradiation Programs Macrophage Differentiation to an iNOS+/M1 Phenotype that Orchestrates Effective T Cell Immunotherapy

(2013) Felix Klug et al.   CANCER CELL

Antitumor immune responses induced by ionizing irradiation and further immune stimulation

(2013) Benjamin Frey et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

Modulation of Inflammatory Immune Reactions by Low-Dose Ionizing Radiation: Molecular Mechanisms and Clinical Application

(2012) F. Rodel et al.   CURRENT MEDICINAL CHEMISTRY

Induction of Abscopal Anti-Tumor Immunity and Immunogenic Tumor Cell Death by Ionizing Irradiation - Implications for Cancer Therapies

(2012) B. Frey et al.   CURRENT MEDICINAL CHEMISTRY

Low dose ionising radiation leads to a NF-κB dependent decreased secretion of active IL-1β by activated macrophages with a discontinuous dose-dependency

(2012) Barbara Lödermann et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Selected anti-tumor vaccines merit a place in multimodal tumor therapies

(2012) Eva-Maria Weiss et al.   Frontiers in Oncology

Dying cell clearance and its impact on the outcome of tumor radiotherapy

(2012) Kirsten Lauber et al.   Frontiers in Oncology

The Efficacy of Radiotherapy Relies upon Induction of Type I Interferon-Dependent Innate and Adaptive Immunity

(2011) B. C. Burnette et al.   CANCER RESEARCH

TGF 1 Inhibition Increases the Radiosensitivity of Breast Cancer Cells In Vitro and Promotes Tumor Control by Radiation In Vivo

(2011) F. Bouquet et al.   CLINICAL CANCER RESEARCH

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti-CTLA-4 Antibody

(2009) M. Z. Dewan et al.   CLINICAL CANCER RESEARCH

AnnexinA5 renders dead tumor cells immunogenic—implications for multimodal cancer therapies

(2009) Benjamin Frey et al.   Journal of Immunotoxicology

The Anti-Inflammatory Effect of Low-Dose Radiation Therapy Involves a Diminished CCL20 Chemokine Expression and Granulocyte/Endothelial Cell Adhesion

(2008) Franz Rödel* et al.   STRAHLENTHERAPIE UND ONKOLOGIE