Article
Multidisciplinary Sciences
Lukasz Charzewski, Krystiana A. Krzysko, Bogdan Lesyng
Summary: MMP-9 is an enzyme that plays important physiological functions but is also involved in pathological processes like cancer invasion, metastasis, and angiogenesis. It may be related to the cytokine storm in COVID-19 and the molecular mechanisms of lung fibrosis. Understanding the interactions between MMP-9 and its natural inhibitor TIMP-1 is crucial for elucidating its regulatory processes.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Igor Yu Dolmatov, Vladimir A. Nizhnichenko, Lyudmila S. Dolmatova
Summary: Echinoderms, an ancient group of invertebrates, have a wide variety of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in their genomes. Phylogenetic analysis shows that MMPs and TIMPs underwent duplication and divergence after the separation of Echinoderms and Chordata. The MMPs of echinoderms have lytic activity towards collagen type I and gelatin, playing important roles in development, asexual reproduction, and regeneration.
Review
Pharmacology & Pharmacy
Kang Fu, Xueyao Zheng, Yuhan Chen, Liuying Wu, Zhiming Yang, Xu Chen, Wei Song
Summary: Diabetic foot ulcers (DFUs) are serious complications of diabetes mellitus, characterized by tissue destruction in the foot. Matrix metalloproteinases (MMPs) play crucial roles in the pathogenesis and wound healing process of DFUs. Overexpression of MMPs in DFUs can result in excessive tissue degradation and impaired wound healing. Regulation of MMP levels may facilitate wound healing in DFUs.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Liang Shan, Fengling Wang, Dandan Zhai, Xiangyun Meng, Jianjun Liu, Xiongwen Lv
Summary: Liver fibrosis is a consequence of chronic liver injuries, characterized by the imbalance of extracellular matrix production and degradation. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are crucial in collagen synthesis and lysis. This article reviews experimental studies on liver fibrosis based on MMPs/TIMPs and highlights the potential of targeting this interaction as a therapeutic strategy for hepatic fibrosis. The article also summarizes drugs, including natural products, that have been found to reduce liver fibrosis by altering the ratio of MMPs/TIMPs.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Helena Laronha, Ines Carpinteiro, Jaime Portugal, Ana Azul, Mario Polido, Krasimira T. Petrova, Madalena Salema-Oom, Isabel Barahona, Jorge Caldeira
Summary: A new class of MMP inhibitors has been discovered, which can be co-polymerized with other vinyl compounds in commercial dental resins, limiting release and potential toxicity, and increasing safety. These inhibitors show unique properties towards various MMPs and did not significantly decrease cell viability at high concentrations.
Article
Fisheries
Zhimeng Lv, Guanghui Han, Chenghua Li
Summary: The TIMP1 gene plays a crucial role in inflammatory diseases in vertebrates, responding to bacterial challenge and LPS exposure. AjTIMP1 is expressed in all tissues, with the highest levels in the body wall. Imbalance in AjMMP1/AjTIMP1 ratio was observed in skin ulceration syndrome patients, leading to an inflammatory response with ROS formation and collagen degradation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Craig N. Morrell, Doran Mix, Anu Aggarwal, Rohan Bhandari, Matthew Godwin, Phillip Owens, Sean P. Lyden, Adam Doyle, Krystin Krauel, Matthew T. Rondina, Amy Mohan, Charles J. Lowenstein, Sharon Shim, Shaun Stauffer, Vara Prasad Josyula, Sara K. Ture, David Yule, Larry E. Wagner, John M. Ashton, Ayman Elbadawi, Scott J. Cameron
Summary: Biomechanical platelet activation may be a potential mechanism behind resistance to antiplatelet medication. A study on patients with abdominal aortic aneurysms (AAA) found that activation of olfactory receptor pathway is associated with AAA progression. A molecule activating platelet olfactory receptor was identified and shown to inhibit platelet activation and AAA growth.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Nutrition & Dietetics
Carla Barbosa Nonino, Natalia Yumi Noronha, Maysa de Araujo Ferreira-Julio, Ligia Moriguchi Watanabe, Karen Francislaine Cassia, Carolina Ferreira Nicoletti, Caroline Rossi Welendorf, Wilson Salgado Junior, Doroteia Rossi Silva Souza, Marcela Augusta de Souza Pinhel
Summary: This study investigated the gene expression of metalloproteinases before and after Roux-en-Y gastric bypass (RYBG) in obese individuals. The results showed that RYGB significantly contributes to weight loss, improved BMI, reduced fat mass, and decreased TIMP2 expression, which might play a role in extracellular matrix remodeling in obesity and could serve as a potential circulating biomarker.
FRONTIERS IN NUTRITION
(2021)
Article
Oncology
Yuka Ikeda, Kurumi Taniguchi, Haruka Sawamura, Sayuri Yoshikawa, Ai Tsuji, Satoru Matsuda
Summary: In this article, the invasiveness of cancer cells in relation to APRO family proteins is discussed. The role of matrix metalloproteinases (MMPs) and exosomes containing specific microRNAs in regulating cancer invasiveness is highlighted. Understanding these mechanisms can lead to innovative strategies for cancer therapy.
Review
Biochemistry & Molecular Biology
Moataz Elgezawi, Rasha Haridy, Khalid Almas, Moamen A. Abdalla, Omar Omar, Hatem Abuohashish, Abeer Elembaby, Uta Christine Woelfle, Yasir Siddiqui, Dalia Kaisarly
Summary: This review article discusses the roles of Matrix metalloproteinases (MMPs) in dental and periodontal tissues, as well as their potential as biomarkers for diagnosis and treatment. The article provides insights into the involvement of MMPs in development, remodeling, degradation, and turnover of dental and periodontal tissues, and their signals in the pathogenesis and wound healing. The review identified 119 published papers, two textbooks, and two doctoral theses as the basis for the discussion. MMPs are seen as significant proteases with potential diagnostic and prognostic value. Understanding their role in dental and periodontal lesions and dentine-pulp wound healing is crucial for future diagnostic and therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Vishnu Mohan, Jean P. Gaffney, Inna Solomonov, Maxim Levin, Mordehay Klepfish, Sophia Akbareian, Barbara Grunwald, Orly Dym, Miriam Eisenstein, Kenneth H. Yu, David P. Kelsen, Achim Kruger, Dylan R. Edwards, Irit Sagi
Summary: The study successfully developed a monoclonal antibody GSM-192 targeting matrix metalloproteinase 7, which induced pancreatic cancer cell apoptosis, reduced migration, and increased sensitivity to chemotherapy.
Article
Medicine, General & Internal
Tetsuji Morishita, Hiroyasu Uzui, Yusuke Sato, Yasuhiko Mitsuke, Hiroshi Tada
Summary: This study investigated the possible relationships between cachexia, metalloproteinases, and haemodynamics in chronic heart failure patients in Japan, the most aged country in the world. The results showed that cachexia was associated with adverse outcomes and increased activity of MMP species and PVR in this population. Cachexia was also found to be an independent predictor of mortality, with specific biomarkers identified as predictors of cardiac cachexia.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Aneta Choreziak-Michalak, Dawid Szpecht, Anna Chmielarz-Czarnocinska, Agnieszka Seremak-Mrozikiewicz, Krzysztof Drews, Grazyna Kurzawinska, Ewa Strauss, Anna Gotz-Wieckowska
Summary: This study investigates the relationship between genetic variations in matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) and the development of retinopathy of prematurity (ROP) in the Polish population. The results suggest that certain genetic variants, including the MMP-1 rs179975 1G deletion allele and TIMP-1 rs4898C allele, are associated with an increased risk of ROP. The study also identifies interactions between multiple genetic loci that impact the risk of ROP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Fisheries
Jinhua An, Chengli Wang, Shaoqing Jian, Yang Gang, Chungen Wen, Baoqing Hu
Summary: In this study, TIMP-1, 2 from Hyriopsis cumingii were cloned and identified, with potential involvement in the immune response and efficient expression in Escherichia coli. The findings suggest that HcTIMP-1, 2 can inhibit metalloproteinase activity and promote cell growth.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alessandro Bonadio, Bernhard L. Wenig, Alexandra Hockla, Evette S. Radisky, Julia M. Shifman
Summary: Researchers have developed a new inhibitor that selectively binds to MMP-14 with higher specificity than conventional inhibitors, using a combination of computational design and combinatorial screening.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Stefano Agnello, Michael Brand, Mathieu F. Chellat, Silvia Gazzola, Rainer Riedl
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Article
Chemistry, Multidisciplinary
Flavio M. Gall, Deborah Hohl, David Frasson, Tobias Wermelinger, Peer R. E. Mittl, Martin Sievers, Rainer Riedl
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Article
Virology
David Kalbermatter, Neeta Shrestha, Nadine Ader-Ebert, Michael Herren, Pascal Moll, Richard K. Plemper, Karl-Heinz Altmann, Johannes P. Langedijk, Flavio Gall, Urs Lindenmann, Rainer Riedl, Dimitrios Fotiadis, Philippe Plattet
Review
Chemistry, Multidisciplinary
Thomas Fischer, Nicole Senn, Rainer Riedl
CHEMISTRY-A EUROPEAN JOURNAL
(2019)
Review
Pharmacology & Pharmacy
Thomas Fischer, Silvia Gazzola, Rainer Riedl
EXPERT OPINION ON DRUG DISCOVERY
(2019)
Article
Chemistry, Medicinal
Urs Lindenmann, Michael Brand, Flavio Gall, David Frasson, Lukas Hunziker, Ivana Kroslakova, Martin Sievers, Rainer Riedl
Article
Chemistry, Multidisciplinary
Stefan Hoeck, Rainer Riedl
JOURNAL OF CHEMINFORMATICS
(2019)
Article
Chemistry, Multidisciplinary
Fabienne Arn, David Frasson, Ivana Kroslakova, Fabio Rezzonico, Joel F. Pothier, Rainer Riedl, Martin Sievers
Review
Pharmacology & Pharmacy
Thomas Fischer, Rainer Riedl
Summary: Matrix metalloproteinases have been a promising target for drug development for decades, with no successful modulators surviving clinical trials so far. Despite this, ongoing research in MMP modulation shows that the target class remains attractive to pharmaceutical research, with potential for successful clinical therapies in the future.
EXPERT OPINION ON DRUG DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Berna Neidhart, Malwina Kowalska, Jules D. P. Valentin, Flavio Max Gall, Qun Ren, Rainer Riedl, Simon Pot, Markus Rottmar
Summary: A cyclic tissue inhibitor of metalloproteinase (TIMP) peptidomimetic downregulates MMP-9 expression and activity, showing potential to reduce tissue damage in infectious keratitis.
Review
Pharmacology & Pharmacy
Alessandra T. Zizzari, Dimanthi Pliatsika, Flavio M. Gall, Thomas Fischer, Rainer Riedl
Summary: Peptides, due to their structural diversity, are considered a unique source of innovative active ingredients, but face challenges in development due to their disadvantageous pharmacokinetic properties. Recent efforts have focused on improving the oral bioavailability of peptide drugs, with the latest findings expected to influence future approaches in developing more efficient and safer orally delivered peptides by pharmaceutical companies.
DRUG DISCOVERY TODAY
(2021)
Article
Virology
Neeta Shrestha, Flavio M. Gall, Jonathan Vesin, Marc Chambon, Gerardo Turcatti, Dimitrios Fotiadis, Rainer Riedl, Philippe Plattet
Summary: Canine distemper virus (CDV) is a close relative of the human pathogen measles virus (MeV) and causes severe diseases in dogs and other carnivores. Vaccinations are available to prevent the disease, but the importance of antivirals against CDV is highlighted by occasional vaccination failures. A cell-based fusion assay identified two membrane fusion inhibitors, showing potential for new therapeutic alternatives against CDV.
Article
Chemistry, Multidisciplinary
Michael Brand, Lei Wang, Stefano Agnello, Silvia Gazzola, Flavio M. Gall, Luka Raguz, Marcel Kaiser, Remo S. Schmidt, Amelie Ritschl, Jennifer Jelk, Andrew Hemphill, Pascal Maser, Peter Butikofer, Michael Adams, Rainer Riedl
Summary: Researchers used Trypanosoma brucei as a model organism to study the potent antiprotozoal compound Leucinostatin A and its derivatives, showing that the main site of action is destabilization of the inner mitochondrial membrane. Resistance to the synthetic derivatives was not observed after long-term exposure and screening of thousands of mutants.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
David Kalbermatter, Neeta Shrestha, Flavio M. Gall, Marianne Wyss, Rainer Riedl, Philippe Plattet, Dimitrios Fotiadis
JOURNAL OF STRUCTURAL BIOLOGY-X
(2020)