Recent opportunities in matrix metalloproteinase inhibitor drug design for cancer

Potential Anti-metastasis Natural Compounds for Lung Cancer

(2016) PITHI CHANVORACHOTE et al.   ANTICANCER RESEARCH

Fluorinated matrix metalloproteinases inhibitors—Phosphonate based potential probes for positron emission tomography

(2016) Bernd Beutel et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Robust design of some selective matrix metalloproteinase-2 inhibitors over matrix metalloproteinase-9 through in silico/fragment-based lead identification and de novo lead modification: Syntheses and biological assays

(2016) Nilanjan Adhikari et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Selective non-zinc binding MMP-2 inhibitors: Novel benzamide Ilomastat analogs with anti-tumor metastasis

(2016) Jiao Song et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fragment-Based Discovery of 5-Arylisatin-Based Inhibitors of Matrix Metalloproteinases 2 and 13

(2016) Mariangela Agamennone et al.   ChemMedChem

Discovery of 2-[2-(5-nitrofuran-2-yl)vinyl]quinoline derivatives as a novel type of antimetastatic agents

(2015) Chih-Hua Tseng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and discovery of (I-3,II-3)-biacacetin as a novel non-zinc binding inhibitor of MMP-2 and MMP-9

(2015) Pandurangan Nanjan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New matrix metalloproteinase inhibitors based on γ-fluorinated α-aminocarboxylic and α-aminohydroxamic acids

(2015) Malte Behrends et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Sulfonamide derivatives containing dihydropyrazole moieties selectively and potently inhibit MMP-2/MMP-9: Design, synthesis, inhibitory activity and 3D-QSAR analysis

(2015) Xiao-Qiang Yan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity

(2015) Elisa Nuti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Current mechanistic insights into the roles of matrix metalloproteinases in tumour invasion and metastasis

(2015) Gordon T Brown et al.   JOURNAL OF PATHOLOGY

Moving targets: Emerging roles for MMPs in cancer progression and metastasis

(2015) Gemma Shay et al.   MATRIX BIOLOGY

Design and synthesis of potent hydroxamate inhibitors with increased selectivity within the gelatinase family

(2015) José María Zapico et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Cancer metastases: challenges and opportunities

(2015) Xiangming Guan   Acta Pharmaceutica Sinica B

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

An Integrated Computational and Experimental Approach to Gaining Selectivity for MMP-2 within the Gelatinase Subfamily

(2014) Benjamin Fabre et al.   CHEMBIOCHEM

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Design, synthesis, evaluation and 3D-QSAR analysis of benzosulfonamide benzenesulfonates as potent and selective inhibitors of MMP-2

(2014) Han-Yue Qiu et al.   RSC Advances

Sulphonamide 1,4-dithia-7-azaspiro[4,4]nonane derivatives as gelatinase A inhibitors

(2013) Leilei Shi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors

(2013) Marilena Tauro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and preliminary evaluation of α-sulfonyl γ-(glycinyl-amino)proline peptidomimetics as matrix metalloproteinase inhibitors

(2013) Jian Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and structure–activity relationship analysis of caffeic acid amides as selective matrix metalloproteinase inhibitors

(2013) Zhi-Hao Shi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Probing the S1′ Site for the Identification of Non-Zinc-Binding MMP-2 Inhibitors

(2013) Antonella Di Pizio et al.   ChemMedChem

Matrix metalloproteinase-9 as a therapeutic target for the progression of fulminant liver failure with hepatic encephalopathy: A pilot study in mice

(2013) Tomohide Hori et al.   HEPATOLOGY RESEARCH

Inverse 1,2,3-Triazole-1-yl-ethyl Substituted Hydroxamates as Highly Potent Matrix Metalloproteinase Inhibitors: (Radio)synthesis, in Vitro and First in Vivo Evaluation

(2013) Verena Hugenberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

O-Phenyl Carbamate and Phenyl Urea Thiiranes as Selective Matrix Metalloproteinase-2 Inhibitors that Cross the Blood–Brain Barrier

(2013) Major Gooyit et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tumor metastasis: moving new biological insights into the clinic

(2013) Liling Wan et al.   NATURE MEDICINE

Progress towards water-soluble triazole-based selective MMP-2 inhibitors

(2013) Benjamin Fabre et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Missing the target: matrix metalloproteinase antitargets in inflammation and cancer

(2013) Antoine Dufour et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Targeting tumor cell motility as a strategy against invasion and metastasis

(2013) Alan Wells et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Design, synthesis and evaluation of novel metalloproteinase inhibitors based on l-tyrosine scaffold

(2012) Xian-Chao Cheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Natural products as a gold mine for selective matrix metalloproteinases inhibitors

(2012) Liyan Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

In silico scaffold evaluation and solid phase approach to identify new gelatinase inhibitors

(2012) Alessandra Topai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

MMP inhibition by barbiturate homodimers

(2012) Jun Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel MT1-MMP Small-Molecule Inhibitors Based on Insights into Hemopexin Domain Function in Tumor Growth

(2012) A. G. Remacle et al.   CANCER RESEARCH

MMP-2 Selectivity in Hydroxamate-Type Inhibitors

(2012) P. Serra et al.   CURRENT MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9

(2012) Orazio Nicolotti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design of Barbiturate–Nitrate Hybrids that Inhibit MMP-9 Activity and Secretion

(2012) Jun Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Increased invasiveness of MMP-9-deficient tumors in two mouse models of neuroendocrine tumorigenesis

(2012) K Shchors et al.   ONCOGENE

Structure–Activity Relationship for Thiirane-Based Gelatinase Inhibitors

(2012) Mijoon Lee et al.   ACS Medicinal Chemistry Letters

N-Substituted homopiperazine barbiturates as gelatinase inhibitors

(2011) Jun Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of novel Cobactin-T based matrix metalloproteinase inhibitors via a ring closing metathesis strategy

(2011) Lawrence J. Wilson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Biphenyl Sulfonylamino Methyl Bisphosphonic Acids as Inhibitors of Matrix Metalloproteinases and Bone Resorption

(2011) Maria Teresa Rubino et al.   ChemMedChem

Structural Basis for Matrix Metalloproteinase-2 (MMP-2)-selective Inhibitory Action of β-Amyloid Precursor Protein-derived Inhibitor

(2011) Hiroshi Hashimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential

(2011) Netta Sela-Passwell et al.   NATURE MEDICINE

Potent “Clicked” MMP2 Inhibitors: Synthesis, Molecular Modeling and Biological Exploration

(2011) Jose María Zapico et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The Intrinsic Protein Flexibility of Endogenous Protease Inhibitor TIMP-1 Controls Its Binding Interface and Affects Its Function

(2010) Moran Grossman et al.   BIOCHEMISTRY

Novel matrix metalloproteinase inhibitors derived from quinoxalinone scaffold (Part I)

(2010) Yonggang Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Concise Syntheses of the Abyssinones and Discovery of New Inhibitors of Prostate Cancer and MMP-2 Expression

(2010) Rebecca L. Farmer et al.   ACS Medicinal Chemistry Letters

Synthesis and evaluation of myxochelin analogues as antimetastatic agents

(2009) Satoshi Miyanaga et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and anticancer activities of ageladine A and structural analogs

(2009) Yuelong Ma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anti-invasive and anti-angiogenic activities of naturally occurring dibenzodiazepine BU-4664L and its derivatives

(2009) Satoshi Miyanaga et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of potential and selective collagenase, gelatinase inhibitors from Crataegus pinnatifida

(2009) Hyung-In Moon et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

(2009) Laetitia Devy et al.   CANCER RESEARCH

Active Site Ring-Opening of a Thiirane Moiety and Picomolar Inhibition of Gelatinases

(2009) Christopher Forbes et al.   Chemical Biology & Drug Design

Selective Matrix Metalloproteinase Inhibitors for Cancer

(2009) Nian-Guang Li et al.   CURRENT MEDICINAL CHEMISTRY

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(2009) Véronique Gouverneur   JOURNAL OF FLUORINE CHEMISTRY

Introduction of the 4-(4-bromophenyl)benzenesulfonyl group to hydrazide analogs of Ilomastat leads to potent gelatinase B (MMP-9) inhibitors with improved selectivity

(2008) Gwennaël LeDour et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and evaluation of novel sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors

(2008) Xian-Chao Cheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Progress in the Development of Matrix Metalloproteinase Inhibitors

(2008) GuoGang Tu et al.   CURRENT MEDICINAL CHEMISTRY

Matrix metalloproteinase inhibitors as anticancer agents

(2007) P KONSTANTINOPOULOS et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY