Minimalist Antibodies and Mimetics: An Update and Recent Applications

Continuous evolution of Bacillus thuringiensis toxins overcomes insect resistance

(2016) Ahmed H. Badran et al.   NATURE

Resurfaced cell-penetrating nanobodies: A potentially general scaffold for intracellularly targeted protein discovery

(2016) Virginia J. Bruce et al.   PROTEIN SCIENCE

Real-time quantification of single RNA translation dynamics in living cells

(2016) T. Morisaki et al.   SCIENCE

Peptides in headlock – a novel high-affinity and versatile peptide-binding nanobody for proteomics and microscopy

(2016) Michael B. Braun et al.   Scientific Reports

Optical imaging of pre-invasive breast cancer with a combination of VHHs targeting CAIX and HER2 increases contrast and facilitates tumour characterization

(2016) Marta M. Kijanka et al.   EJNMMI Research

Camelid single-domain antibody fragments: Uses and prospects to investigate protein misfolding and aggregation, and to treat diseases associated with these phenomena

(2015) Coralie Pain et al.   BIOCHIMIE

HER2 expression status in diverse cancers: review of results from 37,992 patients

(2015) Min Yan et al.   CANCER AND METASTASIS REVIEWS

A Nanobody Activation Immunotherapeutic that Selectively Destroys HER2-Positive Breast Cancer Cells

(2015) Melissa A. Gray et al.   CHEMBIOCHEM

Nanobodies and recombinant binders in cell biology

(2015) Jonas Helma et al.   JOURNAL OF CELL BIOLOGY

Crystal structures of a double-barrelled fluoride ion channel

(2015) Randy B. Stockbridge et al.   NATURE

Monobody-mediated alteration of enzyme specificity

(2015) Shun-ichi Tanaka et al.   Nature Chemical Biology

Two-sided block of a dual-topology F−channel

(2015) Daniel L. Turman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-immunoglobulin scaffolds: a focus on their targets

(2015) Katja Škrlec et al.   TRENDS IN BIOTECHNOLOGY

A Protein-Tagging System for Signal Amplification in Gene Expression and Fluorescence Imaging

(2014) Marvin E. Tanenbaum et al.   CELL

Quantitative ImmunoPET of Prostate Cancer Xenografts with 89Zr- and 124I-Labeled Anti-PSCA A11 Minibody

(2014) S. M. Knowles et al.   JOURNAL OF NUCLEAR MEDICINE

The Effect of Molecular Weight, PK, and Valency on Tumor Biodistribution and Efficacy of Antibody-Based Drugs

(2014) Ruth Muchekehu et al.   Translational Oncology

Naptumomab Estafenatox: Targeted Immunotherapy with a Novel Immunotoxin

(2014) Tim Eisen et al.   Current Oncology Reports

Proof of dual-topology architecture of Fluc F− channels with monobody blockers

(2014) Randy B. Stockbridge et al.   Nature Communications

IgG Subclasses and Allotypes: From Structure to Effector Functions

(2014) Gestur Vidarsson et al.   Frontiers in Immunology

Nanobodies: Natural Single-Domain Antibodies

(2013) Serge Muyldermans   Annual Review of Biochemistry

Efficient export of prefolded, disulfide-bonded recombinant proteins to the periplasm by the Tat pathway in Escherichia coli CyDisCo strains

(2013) Cristina F. R. O. Matos et al.   BIOTECHNOLOGY PROGRESS

Monoclonal antibody-based therapies in cancer: Advances and challenges

(2013) Puja Sapra et al.   PHARMACOLOGY & THERAPEUTICS

Genetically encoded system to track histone modification in vivo

(2013) Yuko Sato et al.   Scientific Reports

Natural Killer Cell Mediated Antibody-Dependent Cellular Cytotoxicity in Tumor Immunotherapy with Therapeutic Antibodies

(2013) Ursula J. E. Seidel et al.   Frontiers in Immunology

Antibody-Recruiting Molecules: An Emerging Paradigm for Engaging Immune Function in Treating Human Disease

(2012) Patrick J. McEnaney et al.   ACS Chemical Biology

Preclinical Evaluation of VB6-845: An Anti-EpCAM Immunotoxin with Reduced Immunogenic Potential

(2012) Joycelyn Entwistle et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Disulfide bond structures of IgG molecules

(2012) Hongcheng Liu et al.   mAbs

Targeting breast carcinoma with radioiodinated anti-HER2 Nanobody

(2012) Marek Pruszynski et al.   NUCLEAR MEDICINE AND BIOLOGY

Human Anti-CCR4 Minibody Gene Transfer for the Treatment of Cutaneous T-Cell Lymphoma

(2012) Thomas Han et al.   PLoS One

Accuracy and safety of 99mTc-labeled anti-D-dimer (DI-80B3) Fab’ fragments (ThromboView®) in the diagnosis of deep vein thrombosis: A phase II study

(2012) James D. Douketis et al.   THROMBOSIS RESEARCH

Non-immunoglobulin based protein scaffolds

(2011) John Löfblom et al.   CURRENT OPINION IN BIOTECHNOLOGY

Preclinical screening of anti-HER2 nanobodies for molecular imaging of breast cancer

(2011) Ilse Vaneycken et al.   FASEB JOURNAL

Analysis and Modeling of the Variable Region of Camelid Single-Domain Antibodies

(2011) A. Sircar et al.   JOURNAL OF IMMUNOLOGY

Anti-CA19-9 Diabody as a PET Imaging Probe for Pancreas Cancer

(2011) Mark D. Girgis et al.   JOURNAL OF SURGICAL RESEARCH

An Engineered Cysteine-Modified Diabody for Imaging Activated Leukocyte Cell Adhesion Molecule (ALCAM)-Positive Tumors

(2011) Katelyn E. McCabe et al.   MOLECULAR IMAGING AND BIOLOGY

A system for the continuous directed evolution of biomolecules

(2011) Kevin M. Esvelt et al.   NATURE

Anti-gp120 Minibody Gene Transfer to Female Genital Epithelial Cells Protects against HIV-1 Virus Challenge In Vitro

(2011) Ussama M. Abdel-Motal et al.   PLoS One

Evaluation of the Anti-HER2 C6.5 Diabody as a PET Radiotracer to Monitor HER2 status and Predict Response to Trastuzumab Treatment

(2010) Smitha Reddy et al.   CLINICAL CANCER RESEARCH

An affinity matured minibody for PET imaging of prostate stem cell antigen (PSCA)-expressing tumors

(2010) Eric J. Lepin et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Importance of Neonatal FcR in Regulating the Serum Half-Life of Therapeutic Proteins Containing the Fc Domain of Human IgG1: A Comparative Study of the Affinity of Monoclonal Antibodies and Fc-Fusion Proteins to Human Neonatal FcR

(2010) Takuo Suzuki et al.   JOURNAL OF IMMUNOLOGY

Cystine-knot peptides engineered with specificities for αIIbβ3 or αIIbβ3 and αvβ3 integrins are potent inhibitors of platelet aggregation

(2010) Adam P. Silverman et al.   JOURNAL OF MOLECULAR RECOGNITION

Antibody fragments

(2010) Aaron L. Nelson   mAbs

Leukemia-specific siRNA delivery by immunonanoplexes consisting of anti-JL1 minibody conjugated to oligo-9 Arg-peptides

(2010) Yeon Kyung Lee et al.   MOLECULES AND CELLS

Structural and thermodynamic analysis of the GFP:GFP-nanobody complex

(2010) Marta H. Kubala et al.   PROTEIN SCIENCE

Challenges in monoclonal antibody-based therapies

(2009) Haritha Samaranayake et al.   ANNALS OF MEDICINE

Applications of single-chain variable fragment antibodies in therapeutics and diagnostics

(2009) Nina E. Weisser et al.   BIOTECHNOLOGY ADVANCES

Engineered protein scaffolds as next-generation antibody therapeutics

(2009) Michaela Gebauer et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

An Antibody-Recruiting Small Molecule That Targets HIV gp120

(2009) Christopher G. Parker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development trends for therapeutic antibody fragments

(2009) Aaron L Nelson et al.   NATURE BIOTECHNOLOGY

Modulation of protein properties in living cells using nanobodies

(2009) Axel Kirchhofer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Neonatal Fc Receptor Mediates Internalization of Fc in Transfected Human Endothelial Cells

(2008) Nancy A. Goebl et al.   MOLECULAR BIOLOGY OF THE CELL

Single-domain antibody fragments with high conformational stability

(2002) Mireille Dumoulin et al.   PROTEIN SCIENCE