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Fragment-based discovery and optimization of BACE1 inhibitors

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Alzheimer's Disease

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Synthesis of potent BACE-1 inhibitors incorporating a hydroxyethylene isostere as central core

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Validation of Molecular Docking Programs for Virtual Screening against Dihydropteroate Synthase

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Design and Synthesis of 5,5′-Disubstituted Aminohydantoins as Potent and Selective Human β-Secretase (BACE1) Inhibitors

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Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

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BACE1 inhibitors: Optimization by replacing the residue with non-acidic moiety

(2008) Yoshio Hamada et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

ONIOM DFT/PM3 calculation on the interaction between STI-571 and abelson tyrosine kinase

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Boom in the development of non-peptidic β-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease

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