A Multidimensional Diversity-Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles

The Synthesis of Structurally Diverse Macrocycles By Successive Ring Expansion

(2015) Christiana Kitsiou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffolds

(2015) Albert Isidro-Llobet et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Diversity-Oriented Synthesis of Drug-Like Macrocyclic Scaffolds Using an Orthogonal Organo- and Metal Catalysis Strategy

(2014) André Grossmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diversity-Oriented Synthesis as a Tool for Chemical Genetics

(2014) Elena Lenci et al.   MOLECULES

How proteins bind macrocycles

(2014) Elizabeth A Villar et al.   Nature Chemical Biology

Advanced Strategies for Efficient Macrocyclic Cu(I)-Catalyzed Cycloaddition of Azides

(2014) Anne-Catherine Bédard et al.   ORGANIC LETTERS

Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties?

(2013) Fabrizio Giordanetto et al.   JOURNAL OF MEDICINAL CHEMISTRY

A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling

(2013) Henning S. G. Beckmann et al.   Nature Chemistry

Solid-Phase Synthesis of Peptide Thioureas and Thiazole-Containing Macrocycles through Ru-Catalyzed Ring-Closing Metathesis

(2013) A. Emil Cohrt et al.   ACS Combinatorial Science

Synthesis of 5-Iodo-1,4-disubstituted-1,2,3-triazoles Mediated by in Situ Generated Copper(I) Catalyst and Electrophilic Triiodide Ion

(2012) Wendy S. Brotherton et al.   JOURNAL OF ORGANIC CHEMISTRY

Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion

(2012) Renato A Bauer et al.   Nature Chemical Biology

A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion

(2012) Felix Kopp et al.   Nature Chemical Biology

A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds

(2012) Kieron M. G. O'Connell et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Build/Couple/Pair Strategy for the Synthesis of Stereochemically Diverse Macrolactams via Head-to-Tail Cyclization

(2012) Mark E. Fitzgerald et al.   ACS Combinatorial Science

Biologically Active Macrocyclic Compounds - from Natural Products to Diversity-Oriented Synthesis

(2011) Charlotte M. Madsen et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Diversity-Oriented Synthesis of 13- to 18-Membered Macrolactams via Ring-Closing Metathesis

(2011) Sivaraman Dandapani et al.   JOURNAL OF ORGANIC CHEMISTRY

Towards the systematic exploration of chemical space

(2011) Mark Dow et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of 5-Iodo-1,2,3-triazole-Containing Macrocycles Using Copper Flow Reactor Technology

(2011) Andrew R. Bogdan et al.   ORGANIC LETTERS

Fragment-based domain shuffling approach for the synthesis of pyran-based macrocycles

(2011) E. Comer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diversity-oriented synthesis of macrocyclic peptidomimetics

(2011) A. Isidro-Llobet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors

(2010) Lisa A. Marcaurelle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

(2010) Warren R.J.D. Galloway et al.   Nature Communications

The Scope and Limitations of Intramolecular Nicholas and Pauson−Khand Reactions for the Synthesis of Tricyclic Oxygen- and Nitrogen-Containing Heterocycles

(2009) Kristina D. Closser et al.   JOURNAL OF ORGANIC CHEMISTRY

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY

Towards the Optimal Screening Collection: A Synthesis Strategy

(2007) Thomas E. Nielsen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION