Viral and Cellular Requirements for the Nuclear Entry of Retroviral Preintegration Nucleoprotein Complexes

Discovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid Complexes

(2013) Louie Lamorte et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Interaction of Transportin-SR2 with Ras-related Nuclear Protein (Ran) GTPase

(2013) Oliver Taltynov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Analysis of the C-Terminal Domain of Nup358/RanBP2

(2013) Daniel H. Lin et al.   JOURNAL OF MOLECULAR BIOLOGY

A Carboxy-Terminally Truncated Human CPSF6 Lacking Residues Encoded by Exon 6 Inhibits HIV-1 cDNA Synthesis and Promotes Capsid Disassembly

(2013) T. Hori et al.   JOURNAL OF VIROLOGY

Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics

(2013) Gongpu Zhao et al.   NATURE

Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection

(2013) Caroline Goujon et al.   NATURE

Viral DNA tethering domains complement replication-defective mutations in the p12 protein of MuLV Gag

(2013) William M. Schneider et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Cell Imaging of HIV-1 Provirus (SCIP)

(2013) C. Di Primio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 capsid undergoes coupled binding and isomerization by the nuclear pore protein NUP358

(2013) Katsiaryna Bichel et al.   Retrovirology

The ability of TNPO3-depleted cells to inhibit HIV-1 infection requires CPSF6

(2013) Thomas Fricke et al.   Retrovirology

Heterogeneous susceptibility of circulating SIV isolate capsids to HIV-interacting factors

(2013) João I Mamede et al.   Retrovirology

Quantitative analysis of the time-course of viral DNA forms during the HIV-1 life cycle

(2013) Soundasse Munir et al.   Retrovirology

TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm

(2013) Alberto De Iaco et al.   Retrovirology

The importance of becoming double-stranded: Innate immunity and the kinetic model of HIV-1 central plus strand synthesis

(2013) Eric Poeschla   VIROLOGY

Nup153 and Nup98 bind the HIV-1 core and contribute to the early steps of HIV-1 replication

(2013) Francesca Di Nunzio et al.   VIROLOGY

p12 Tethers the Murine Leukemia Virus Pre-integration Complex to Mitotic Chromosomes

(2013) Efrat Elis et al.   PLoS Pathogens

Nucleoporin NUP153 Phenylalanine-Glycine Motifs Engage a Common Binding Pocket within the HIV-1 Capsid Protein to Mediate Lentiviral Infectivity

(2013) Kenneth A. Matreyek et al.   PLoS Pathogens

Fates of Retroviral Core Components during Unrestricted and TRIM5-Restricted Infection

(2013) Sebla B. Kutluay et al.   PLoS Pathogens

Interaction of the HIV-1 Intasome with Transportin 3 Protein (TNPO3 or TRN-SR2)

(2012) Ross Larue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Residues in the C-terminal Domain of HIV-1 Integrase That Mediate Binding to the Transportin-SR2 Protein

(2012) Stephanie De Houwer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unclosed HIV-1 Capsids Suggest a Curled Sheet Model of Assembly

(2012) Zhiheng Yu et al.   JOURNAL OF MOLECULAR BIOLOGY

HIV-1 Capsid-Targeting Domain of Cleavage and Polyadenylation Specificity Factor 6

(2012) K. Lee et al.   JOURNAL OF VIROLOGY

Differential Effects of Human Immunodeficiency Virus Type 1 Capsid and Cellular Factors Nucleoporin 153 and LEDGF/p75 on the Efficiency and Specificity of Viral DNA Integration

(2012) Y. Koh et al.   JOURNAL OF VIROLOGY

Human Immunodeficiency Virus Type 1 Capsid Mutation N74D Alters Cyclophilin A Dependence and Impairs Macrophage Infection

(2012) Zandrea Ambrose et al.   JOURNAL OF VIROLOGY

TNPO3 Is Required for HIV-1 Replication after Nuclear Import but prior to Integration and Binds the HIV-1 Core

(2012) J. C. Valle-Casuso et al.   JOURNAL OF VIROLOGY

The Host Proteins Transportin SR2/TNPO3 and Cyclophilin A Exert Opposing Effects on HIV-1 Uncoating

(2012) V. B. Shah et al.   JOURNAL OF VIROLOGY

Human Nucleoporins Promote HIV-1 Docking at the Nuclear Pore, Nuclear Import and Integration

(2012) Francesca Di Nunzio et al.   PLoS One

Capturing directed molecular motion in the nuclear pore complex of live cells

(2012) F. Cardarelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Superresolution imaging of HIV in infected cells with FlAsH-PALM

(2012) M. Lelek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recruitment and Dynamics of Proteasome Association with rhTRIM5α Cytoplasmic Complexes During HIV-1 Infection

(2012) Cindy M. Danielson et al.   TRAFFIC

HIV taken by STORM: Super-resolution fluorescence microscopy of a viral infection

(2012) Cândida F Pereira et al.   Virology Journal

CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication

(2012) Amanda J. Price et al.   PLoS Pathogens

The Structure of the Nuclear Pore Complex

(2011) André Hoelz et al.   Annual Review of Biochemistry

The Requirement for Nucleoporin NUP153 during Human Immunodeficiency Virus Type 1 Infection Is Determined by the Viral Capsid

(2011) K. A. Matreyek et al.   JOURNAL OF VIROLOGY

LEDGF Dominant Interference Proteins Demonstrate Prenuclear Exposure of HIV-1 Integrase and Synergize with LEDGF Depletion To Destroy Viral Infectivity

(2011) A. M. Meehan et al.   JOURNAL OF VIROLOGY

The Cargo-Binding Domain of Transportin 3 Is Required for Lentivirus Nuclear Import

(2011) E. C. Logue et al.   JOURNAL OF VIROLOGY

Atomic-level modelling of the HIV capsid

(2011) Owen Pornillos et al.   NATURE

Ordered assembly of murine leukemia virus capsid protein on lipid nanotubes directs specific binding by the restriction factor, Fv1

(2011) L. Hilditch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complementary assays reveal a relationship between HIV-1 uncoating and reverse transcription

(2011) A. E. Hulme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interplay between HIV Entry and Transportin-SR2 Dependency

(2011) Wannes Thys et al.   Retrovirology

Inhibition of HIV-1 infection by TNPO3 depletion is determined by capsid and detectable after viral cDNA enters the nucleus

(2011) Alberto De Iaco et al.   Retrovirology

Mutations affecting interaction of integrase with TNPO3 do not prevent HIV-1 cDNA nuclear import

(2011) Alexandra Cribier et al.   Retrovirology

HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency

(2011) Torsten Schaller et al.   PLoS Pathogens

HIV Integration Targeting: A Pathway Involving Transportin-3 and the Nuclear Pore Protein RanBP2

(2011) Karen E. Ocwieja et al.   PLoS Pathogens

Transportin 3 Promotes a Nuclear Maturation Step Required for Efficient HIV-1 Integration

(2011) Lihong Zhou et al.   PLoS Pathogens

Flexible Use of Nuclear Import Pathways by HIV-1

(2010) KyeongEun Lee et al.   Cell Host & Microbe

Structural and Functional Analysis of Prehistoric Lentiviruses Uncovers an Ancient Molecular Interface

(2010) David C. Goldstone et al.   Cell Host & Microbe

An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1

(2010) Masako Koyama et al.   EMBO JOURNAL

Gyrase B Inhibitor Impairs HIV-1 Replication by Targeting Hsp90 and the Capsid Protein

(2010) Luciano Vozzolo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Importin  3 Interacts with HIV-1 Integrase and Contributes to HIV-1 Nuclear Import and Replication

(2010) Z. Ao et al.   JOURNAL OF VIROLOGY

The HIV-1 Central Polypurine Tract Functions as a Second Line of Defense against APOBEC3G/F

(2010) C. Hu et al.   JOURNAL OF VIROLOGY

Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Infection by Virus Capsid Destabilization

(2010) J. Shi et al.   JOURNAL OF VIROLOGY

Retroviral intasome assembly and inhibition of DNA strand transfer

(2010) Stephen Hare et al.   NATURE

Perturbation of Host Nuclear Membrane Component RanBP2 Impairs the Nuclear Import of Human Immunodeficiency Virus -1 Preintegration Complex (DNA)

(2010) Ruonan Zhang et al.   PLoS One

Nuclear Pore Proteins Nup153 and Megator Define Transcriptionally Active Regions in the Drosophila Genome

(2010) Juan M. Vaquerizas et al.   PLoS Genetics

HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention

(2010) Wade S. Blair et al.   PLoS Pathogens

The Gag Cleavage Product, p12, is a Functional Constituent of the Murine Leukemia Virus Pre-Integration Complex

(2010) Adi Prizan-Ravid et al.   PLoS Pathogens

X-Ray Structures of the Hexameric Building Block of the HIV Capsid

(2009) Owen Pornillos et al.   CELL

Flexible Gates: Dynamic Topologies and Functions for FG Nucleoporins in Nucleocytoplasmic Transport

(2009) Laura J. Terry et al.   EUKARYOTIC CELL

A Genome-wide Short Hairpin RNA Screening of Jurkat T-cells for Human Proteins Contributing to Productive HIV-1 Replication

(2009) Man Lung Yeung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of the Viral Elements Required in the Nuclear Import of HIV-1 DNA

(2009) L. Riviere et al.   JOURNAL OF VIROLOGY

The Requirement for Cellular Transportin 3 (TNPO3 or TRN-SR2) during Infection Maps to Human Immunodeficiency Virus Type 1 Capsid and Not Integrase

(2009) L. Krishnan et al.   JOURNAL OF VIROLOGY

Integrase Interacts with Nucleoporin NUP153 To Mediate the Nuclear Import of Human Immunodeficiency Virus Type 1

(2009) C. L. Woodward et al.   JOURNAL OF VIROLOGY

Characterization of the Behavior of Functional Viral Genomes during the Early Steps of Human Immunodeficiency Virus Type 1 Infection

(2009) V. Arfi et al.   JOURNAL OF VIROLOGY

Target Cell Type-Dependent Modulation of Human Immunodeficiency Virus Type 1 Capsid Disassembly by Cyclophilin A

(2009) Y. Li et al.   JOURNAL OF VIROLOGY

The SET Complex Acts as a Barrier to Autointegration of HIV-1

(2009) Nan Yan et al.   PLoS Pathogens

Host Cell Factors in HIV Replication: Meta-Analysis of Genome-Wide Studies

(2009) Frederic D. Bushman et al.   PLoS Pathogens

Global Analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication

(2008) Renate König et al.   CELL

Resolution of Sister Centromeres Requires RanBP2-Mediated SUMOylation of Topoisomerase IIα

(2008) Meelad M. Dawlaty et al.   CELL

Genome-Scale RNAi Screen for Host Factors Required for HIV Replication

(2008) Honglin Zhou et al.   Cell Host & Microbe

Transportin-SR2 Imports HIV into the Nucleus

(2008) Frauke Christ et al.   CURRENT BIOLOGY

Compensatory Role of Human Immunodeficiency Virus Central Polypurine Tract Sequence in Kinetically Disrupted Reverse Transcription

(2008) M. Skasko et al.   JOURNAL OF VIROLOGY

Cyclophilin A Levels Dictate Infection Efficiency of Human Immunodeficiency Virus Type 1 Capsid Escape Mutants A92E and G94D

(2008) L. M. J. Ylinen et al.   JOURNAL OF VIROLOGY

Cyclophilin A-Dependent Restriction of Human Immunodeficiency Virus Type 1 Capsid Mutants for Infection of Nondividing Cells

(2008) M. Qi et al.   JOURNAL OF VIROLOGY

Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen

(2008) Abraham L. Brass et al.   SCIENCE