Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis

The HNF1α-regulated lncRNA HNF1α-AS1 is Involved in the Regulation of Cytochrome P450 Expression in Human Liver Tissues and Huh7 Cells

(2019) Yiting Wang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

miR-1275 controls granulosa cell apoptosis and estradiol synthesis by impairing LRH-1/CYP19A1 axis

(2018) Jiying Liu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Current knowledge of microRNA-mediated regulation of drug metabolism in humans

(2018) Masataka Nakano et al.   Expert Opinion on Drug Metabolism & Toxicology

Upregulation of microRNA-320 decreases the risk of developing steroid-induced avascular necrosis of femoral head by inhibiting CYP1A2 both in vivo and in vitro

(2018) Ji-Hua Wei et al.   GENE

A Transcriptional Regulatory Network Containing Nuclear Receptors and Long Noncoding RNAs Controls Basal and Drug-Induced Expression of Cytochrome P450s in HepaRG Cells

(2018) Liming Chen et al.   MOLECULAR PHARMACOLOGY

miR‑204 functions as a tumor suppressor gene, at least partly by suppressing CYP27A1 in glioblastoma

(2018) Jun Xin et al.   Oncology Letters

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Negative Regulation of Human Pregnane X Receptor by MicroRNA-18a-5p: Evidence for Suppression of MicroRNA-18a-5p Expression by Rifampin and Rilpivirine

(2017) Devinder Sharma et al.   MOLECULAR PHARMACOLOGY

Suppression of miR-628-3p and miR-641 is involved in rifampin-mediated CYP3A4 induction in HepaRG cells

(2017) Liang Yan et al.   PHARMACOGENOMICS

MicroRNA-27a-3p affects estradiol and androgen imbalance by targeting Creb1 in the granulosa cells in mouse polycytic ovary syndrome model

(2017) Mingming Wang et al.   Reproductive Biology

Sex-Differential Responses of Tumor Promotion-Associated Genes and Dysregulation of Novel Long Noncoding RNAs in Constitutive Androstane Receptor-Activated Mouse Liver

(2017) Nicholas J. Lodato et al.   TOXICOLOGICAL SCIENCES

MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity

(2017) Pritmohinder Gill et al.   Scientific Reports

Clinical Relevance of Circulating, Cell-Free and Exosomal microRNAs in Plasma and Serum of Breast Cancer Patients

(2017) Heidi Schwarzenbach   Oncology Research and Treatment

Cytochrome P450-mediated metabolism of triclosan attenuates its cytotoxicity in hepatic cells

(2016) Yuanfeng Wu et al.   ARCHIVES OF TOXICOLOGY

MicroRNA-187-5p suppresses cancer cell progression in non-small cell lung cancer (NSCLC) through down-regulation of CYP1B1

(2016) Ming Mao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CYP4Z1 3′UTR represses migration of human breast cancer cells

(2016) Bingyu Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA hsa-miR-25-3p suppresses the expression and drug induction of CYP2B6 in human hepatocytes

(2016) Yaqiong Jin et al.   BIOCHEMICAL PHARMACOLOGY

MicroRNA-30c-1-3p is a silencer of the pregnane X receptor by targeting the 3′-untranslated region and alters the expression of its target gene cytochrome P450 3A4

(2016) Thaveechai Vachirayonstien et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A dual inhibition: microRNA-552 suppresses both transcription and translation of cytochrome P450 2E1

(2016) Lingling Miao et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Micro RNA-550a interferes with vitamin D metabolism in peripheral B cells of patients with diabetes

(2016) Jinggui He et al.   CELL BIOCHEMISTRY AND FUNCTION

Cytotoxicity of pyrrolizidine alkaloid in human hepatic parenchymal and sinusoidal endothelial cells: Firm evidence for the reactive metabolites mediated pyrrolizidine alkaloid-induced hepatotoxicity

(2016) Mengbi Yang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Exposure to organophosphorus and organochlorine pesticides, perfluoroalkyl substances, and polychlorinated biphenyls in pregnancy and the association with impaired glucose tolerance and gestational diabetes mellitus: The MIREC Study

(2016) Gabriel D. Shapiro et al.   ENVIRONMENTAL RESEARCH

A novel long noncoding RNA Lnc-HC binds hnRNPA2B1 to regulate expressions of Cyp7a1 and Abca1 in hepatocytic cholesterol metabolism

(2016) Xi Lan et al.   HEPATOLOGY

MicroRNA-17 induces epithelial-mesenchymal transition consistent with the cancer stem cell phenotype by regulating CYP7B1 expression in colon cancer

(2016) Xiang-Peng Xi et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Identification of male-biased microRNA-107 as a direct regulator for nuclear receptor subfamily 5 group A member 1 based on sexually dimorphic microRNA expression profiling from chicken embryonic gonads

(2016) Nan Miao et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Clinical relevance of circulating cell-free microRNAs in ovarian cancer

(2016) Koji Nakamura et al.   Molecular Cancer

Loss of miR-125b contributes to upregulation of CYP24 in uraemic rats

(2016) Lihua Wang et al.   NEPHROLOGY

MicroRNA Biomarkers of Toxicity in Biological Matrices

(2016) Alison H. Harrill et al.   TOXICOLOGICAL SCIENCES

Long Non-Coding RNAs: A Novel Paradigm for Toxicology

(2016) Joseph L. Dempsey et al.   TOXICOLOGICAL SCIENCES

BDE47 induces rat CYP3A1 by targeting the transcriptional regulation of miR-23b

(2016) Zhenzhen Sun et al.   Scientific Reports

Biotransformation of 8:2 fluorotelomer alcohol by recombinant human cytochrome P450s, human liver microsomes and human liver cytosol

(2016) Zhong-Min Li et al.   Environmental Science-Processes & Impacts

Long noncoding RNAs and Alzheimer's disease

(2016) Qiong Luo et al.   Clinical Interventions in Aging

Environment and the Inflammatory Bowel Diseases

(2016) Alexandra Frolkis et al.   CANADIAN JOURNAL OF GASTROENTEROLOGY

The independent contribution of miRNAs to the missing heritability in CYP3A4/5 functionality and the metabolism of atorvastatin

(2016) Ju-E Liu et al.   Scientific Reports

The role of microRNAs in toxicology

(2015) Hong W. Yu et al.   ARCHIVES OF TOXICOLOGY

miR-138-1* regulates aflatoxin B1-induced malignant transformation of BEAS-2B cells by targeting PDK1

(2015) Yun Wang et al.   ARCHIVES OF TOXICOLOGY

Emerging role of long noncoding RNAs in autoimmune diseases

(2015) Guo-Cui Wu et al.   AUTOIMMUNITY REVIEWS

MicroRNA hsa-miR-29a-3p modulates CYP2C19 in human liver cells

(2015) Dianke Yu et al.   BIOCHEMICAL PHARMACOLOGY

microRNAs as pharmacogenomic biomarkers for drug efficacy and drug safety assessment

(2015) Igor Koturbash et al.   Biomarkers in Medicine

Sex hormones regulate cerebral drug metabolism via brain miRNAs: down-regulation of brain CYP2D by androgens reduces the analgesic effects of tramadol

(2015) Jie Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Liver-Enriched Long Non-Coding RNA, lncLSTR, Regulates Systemic Lipid Metabolism in Mice

(2015) Ping Li et al.   Cell Metabolism

Long Noncoding RNAs in Cardiovascular Diseases

(2015) S. Uchida et al.   CIRCULATION RESEARCH

Epigenetic Regulation of Cytochrome P450 Enzymes and Clinical Implication

(2015) Xiaojing Tang et al.   CURRENT DRUG METABOLISM

MicroRNAs as Potential Signatures of Environmental Exposure or Effect: A Systematic Review

(2015) Karen Vrijens et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The role for microRNAs in drug toxicity and in safety assessment

(2015) April K Marrone et al.   Expert Opinion on Drug Metabolism & Toxicology

In vivo toxicity studies of fusarium mycotoxins in the last decade: A review

(2015) L. Escrivá et al.   FOOD AND CHEMICAL TOXICOLOGY

MicroRNA-764-3p regulates 17β-estradiol synthesis of mouse ovarian granulosa cells by targeting steroidogenic factor-1

(2015) Lianlian Wang et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Functional roles of non-coding Y RNAs

(2015) Madzia P. Kowalski et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The emerging role of lncRNAs in cancer

(2015) Maite Huarte   NATURE MEDICINE

Bioinformatic tools for microRNA dissection

(2015) Most Mauluda Akhtar et al.   NUCLEIC ACIDS RESEARCH

NONCODE 2016: an informative and valuable data source of long non-coding RNAs

(2015) Yi Zhao et al.   NUCLEIC ACIDS RESEARCH

Hsa-miR-27a is involved in the regulation ofCYP3A4expression in human livers from Chinese Han population

(2015) Ye Shi et al.   PHARMACOGENOMICS

Long Noncoding RNAs: A New Regulatory Code in Metabolic Control

(2015) Xu-Yun Zhao et al.   TRENDS IN BIOCHEMICAL SCIENCES

Loss of miR-200c up-regulates CYP1B1 and confers docetaxel resistance in renal cell carcinoma

(2015) Inik Chang et al.   Oncotarget

MicroRNA-195 inhibits proliferation, invasion and metastasis in breast cancer cells by targeting FASN, HMGCR, ACACA and CYP27B1

(2015) Richa Singh et al.   Scientific Reports

Suppression of CYP2C9 by MicroRNA hsa-miR-128-3p in Human Liver Cells and Association with Hepatocellular Carcinoma

(2015) Dianke Yu et al.   Scientific Reports

Triclosan: Current Status, Occurrence, Environmental Risks and Bioaccumulation Potential

(2015) Gurpreet Dhillon et al.   International Journal of Environmental Research and Public Health

Analysis of DNA methylation landscape reveals the roles of DNA methylation in the regulation of drug metabolizing enzymes

(2015) Wataru Habano et al.   Clinical Epigenetics

Involvement of Cytochrome P450 1A1 and Glutathione S-Transferase P1 Polymorphisms and Promoter Hypermethylation in the Progression of Anti-Tuberculosis Drug-Induced Liver Injury: A Case–Control Study

(2015) Lei He et al.   PLoS One

MicroRNAs as key regulators of xenobiotic biotransformation and drug response

(2014) Jennifer Bolleyn et al.   ARCHIVES OF TOXICOLOGY

Retinoid X receptor α in human liver is regulated by miR-34a

(2014) Yuki Oda et al.   BIOCHEMICAL PHARMACOLOGY

Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3

(2014) S A A Patel et al.   BRITISH JOURNAL OF CANCER

Noncoding RNA response to xenobiotic exposure: an indicator of toxicity and carcinogenicity

(2014) April K Marrone et al.   Expert Opinion on Drug Metabolism & Toxicology

The effects of environmental chemical carcinogens on the microRNA machinery

(2014) A. Izzotti et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Plasma miR-208 as a useful biomarker for drug-induced cardiotoxicity in rats

(2014) Yoko Nishimura et al.   JOURNAL OF APPLIED TOXICOLOGY

Toxicogenomics and Cancer Susceptibility: Advances with Next-Generation Sequencing

(2014) Baitang Ning et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Clinical relevance of circulating cell-free microRNAs in cancer

(2014) Heidi Schwarzenbach et al.   Nature Reviews Clinical Oncology

Expression of genes involved in xenobiotic metabolism and transport in end-stage liver disease: up-regulation of ABCC4 and CYP1B1

(2014) Mateusz Kurzawski et al.   Pharmacological Reports

Aberrant microRNA Expression Likely Controls RAS Oncogene Activation During Malignant Transformation of Human Prostate Epithelial and Stem Cells by Arsenic

(2014) Ntube N. O. Ngalame et al.   TOXICOLOGICAL SCIENCES

A review on the molecular mechanisms involved in insulin resistance induced by organophosphorus pesticides

(2014) Mohamed Montassar Lasram et al.   TOXICOLOGY

Fumonisin B1 modulates expression of human cytochrome P450 1b1 in human hepatoma (Hepg2) cells by repressing Mir-27b

(2014) Anil A. Chuturgoon et al.   TOXICOLOGY LETTERS

MicroRNAs in cancer: biomarkers, functions and therapy

(2014) Josie Hayes et al.   TRENDS IN MOLECULAR MEDICINE

The Effect of microRNAs in the Regulation of Human CYP3A4: a Systematic Study using a Mathematical Model

(2014) Zhiyun Wei et al.   Scientific Reports

The microRNAs as potential biomarkers for predicting the onset of aflatoxin exposure in human beings: a review

(2014) Rafael Valencia-Quintana et al.   Frontiers in Microbiology

Characterization of a Novel Long Noncoding RNA, SCAL1, Induced by Cigarette Smoke and Elevated in Lung Cancer Cell Lines

(2013) Philip Thai et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Long Noncoding RNAs: Cellular Address Codes in Development and Disease

(2013) Pedro J. Batista et al.   CELL

MicroRNA-133b stimulates ovarian estradiol synthesis by targeting Foxl2

(2013) Anyi Dai et al.   FEBS LETTERS

Combined effects of organochlorine pesticides heptachlor and hexachlorobenzene on the promotion stage of hepatocarcinogenesis in rats

(2013) Walied Abdo et al.   FOOD AND CHEMICAL TOXICOLOGY

Long Noncoding RNAs: Past, Present, and Future

(2013) J. T. Y. Kung et al.   GENETICS

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

(2013) Daniel J. Antoine et al.   HEPATOLOGY

The c-Myc-Regulated MicroRNA-17∼92 (miR-17∼92) and miR-106a∼363 Clusters Target hCYP19A1 and hGCM1 To Inhibit Human Trophoblast Differentiation

(2013) Premlata Kumar et al.   MOLECULAR AND CELLULAR BIOLOGY

Long non-coding RNAs: new players in cell differentiation and development

(2013) Alessandro Fatica et al.   NATURE REVIEWS GENETICS

Mechanistic biomarkers for clinical decision making in rheumatic diseases

(2013) William H. Robinson et al.   Nature Reviews Rheumatology

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

On the classification of long non-coding RNAs

(2013) Lina Ma et al.   RNA Biology

Environmental exposures, epigenetics and cardiovascular disease

(2012) Andrea Baccarelli et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

CYP1A1 is a target of miR-892a-mediated post-transcriptional repression

(2012) Seunghee Bae   INTERNATIONAL JOURNAL OF ONCOLOGY

MicroRNA and cancer

(2012) Martin D. Jansson et al.   Molecular Oncology

Landscape of transcription in human cells

(2012) Sarah Djebali et al.   NATURE

Plasma MicroRNA Profiles in Rat Models of Hepatocellular Injury, Cholestasis, and Steatosis

(2012) Yu Yamaura et al.   PLoS One

Biomarkers for Drug-Induced Renal Damage and Nephrotoxicity—An Overview for Applied Toxicology

(2011) Tobias Christian Fuchs et al.   AAPS Journal

Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment

(2011) C. M. McHale et al.   CARCINOGENESIS

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Steroid Regulation of Drug-Metabolizing Cytochromes P450

(2011) Katalin Monostory et al.   CURRENT DRUG METABOLISM

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

Environmental chemicals and microRNAs

(2011) Lifang Hou et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Extracellular microRNA: A new source of biomarkers

(2011) Alton Etheridge et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

(2011) Eric Huntzinger et al.   NATURE REVIEWS GENETICS

Long noncoding RNAs in cell biology

(2011) Michael B. Clark et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Long noncoding RNAs and human disease

(2011) Orly Wapinski et al.   TRENDS IN CELL BIOLOGY

Regulation of microRNA expression and function by nuclear receptor signaling

(2011) Zhihong Yang et al.   Cell and Bioscience

Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis

(2010) Nobuyoshi Kosaka et al.   CANCER SCIENCE

Plasma MicroRNA-122 as a Biomarker for Viral-, Alcohol-, and Chemical-Related Hepatic Diseases

(2010) Y. Zhang et al.   CLINICAL CHEMISTRY

MicroRNA: Biogenesis, Function and Role in Cancer

(2010) Leigh-Ann MacFarlane et al.   CURRENT GENOMICS

Histone modification-mediated CYP2E1 gene expression and apoptosis of HepG2 cells

(2010) Hui Yang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Serum microRNAs as non-invasive biomarkers for cancer

(2010) Jan C Brase et al.   Molecular Cancer

Human CYP2E1 is regulated by miR-378

(2009) Takuya Mohri et al.   BIOCHEMICAL PHARMACOLOGY

Plasma miR-208 as a Biomarker of Myocardial Injury

(2009) X. Ji et al.   CLINICAL CHEMISTRY

Epigenetics and environmental chemicals

(2009) Andrea Baccarelli et al.   CURRENT OPINION IN PEDIATRICS

Polymorphism of human cytochrome P450 enzymes and its clinical impact

(2009) Shu-Feng Zhou et al.   DRUG METABOLISM REVIEWS

Relationships of microRNA expression in mouse lung with age and exposure to cigarette smoke and light

(2009) Alberto Izzotti et al.   FASEB JOURNAL

MicroRNAs: Potential biomarkers for cancer diagnosis, prognosis and targets for therapy

(2009) William C.S. Cho   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Linking DNA methylation and histone modification: patterns and paradigms

(2009) Howard Cedar et al.   NATURE REVIEWS GENETICS

Environmental signals and transgenerational epigenetics

(2009) Michael K Skinner et al.   Epigenomics

Differential expression of microRNAs in early-stage neoplastic transformation in the lungs of F344 rats chronically treated with the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

(2008) Stephen Kalscheuer et al.   CARCINOGENESIS

Drugs Behave as Substrates, Inhibitors and Inducers of Human Cytochrome P450 3A4

(2008) Shu-Feng Zhou   CURRENT DRUG METABOLISM

Xenobiotic-Induced Transcriptional Regulation of Xenobiotic Metabolizing Enzymes of the Cytochrome P450 Superfamily in Human Extrahepatic Tissues

(2008) Petr Pavek et al.   CURRENT DRUG METABOLISM

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Post-transcriptional Regulation of Human Pregnane X Receptor by Micro-RNA Affects the Expression of Cytochrome P450 3A4

(2008) Shingo Takagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Environmental exposure measurement in cancer epidemiology

(2008) C. P. Wild   MUTAGENESIS

Genotoxicity of heptachlor and heptachlor epoxide in human TK6 lymphoblastoid cells

(2008) Guadalupe Prado et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Biological principles of microRNA-mediated regulation: shared themes amid diversity

(2008) Alex S. Flynt et al.   NATURE REVIEWS GENETICS

Small non-coding RNAs in animal development

(2008) Giovanni Stefani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CYP2E1 and oxidative liver injury by alcohol

(2007) Yongke Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE