Article
Environmental Sciences
Prasenjit Mitra, Taru Goyal, Preeti Singh, Shailja Sharma, Praveen Sharma
Summary: The study found that miR-155 and miR-221 were significantly upregulated in occupationally lead-exposed workers, while miR-20b showed no significant difference. These miRNAs have the potential to trigger various genes and cellular pathways, highlighting the importance of miRNA dysregulation in the systemic effects of lead toxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Sorin Giusca, Grigorios Korosoglou, Moritz Montenbruck, Blaz Gersak, Arne Kristian Schwarz, Sebastian Esch, Sebastian Kelle, Pia Wuelfing, Susan Dent, Daniel Lenihan, Henning Steen
Summary: The study found that the percentage of normal myocardium derived from fast-strain-encoded cardiovascular magnetic resonance can more accurately detect and predict cardiac dysfunction in cancer patients undergoing cardiotoxic chemotherapy, demonstrating good performance in predicting who will develop CTX.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Article
Biochemistry & Molecular Biology
Jiung-Pang Huang, Chih-Chun Chang, Chao-Yu Kuo, Kuang-Jing Huang, Etienne M. Sokal, Kuan-Hsing Chen, Li-Man Hung
Summary: EXO-miRNAs have the potential to be used as biomarkers for diabetic HFpEF. The study found that miR-30d-5p and miR-126a-5p were associated with HFpEF, and may be important for the development of diagnostic tools for diabetic HFpEF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Yajie Guo, Junhua Yuan, Hao Ni, Jing Ji, Shuping Zhong, Yuxin Zheng, Qixiao Jiang
Summary: MiR-490-5p and its downstream genes SNAP91 and LYPD6 are involved in PFOA-induced developmental cardiotoxicity in chicken embryos, which helps to further understand the mechanism of PFOA-induced cardiac toxicity.
ENVIRONMENTAL POLLUTION
(2022)
Article
Obstetrics & Gynecology
Delnya Gholami, Farzane Amirmahani, Reza Salman Yazdi, Tahereh Hasheminia, Hossein Teimori
Summary: The study found that up-regulation of miR-182-5p, miR-192-5p, and miR-493-5p may serve as potential biomarkers for TZ. Additionally, the expression level of the CRISP3 glycosylated isoform was significantly lower in TZ patients compared to those with normal sperm. These results suggest a significant role of CRISP3 protein and miRs in male infertility.
REPRODUCTIVE SCIENCES
(2021)
Review
Oncology
D. Delombaerde, D. Vervloet, C. Franssen, L. Croes, F. Gremonprez, H. Prenen, M. Peeters, C. Vulsteke
Summary: Cardiovascular adverse events induced by immune checkpoint inhibitors have gained significant interest, with increasing discussions regarding their impact. Currently, there are no specific guidelines for the interpretation of asymptomatic rise in troponins.
Article
Geriatrics & Gerontology
Nermeen Z. Abuelezz, Fayza Eid Nasr, Waleed M. Abdel Aal, Tarek Molokhia, Amira Zaky
Summary: The study found that serum miR-34a, miR-29b, and miR-181c were significantly downregulated in AD patients and associated with cognitive decline. AD patients also showed elevated levels of Aβ42, pTau, and TNF-α. The measured miRNAs had good AD diagnostic value alone and when combined with other biomarkers, significantly improving diagnostic power.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Cell Biology
Barbara N. Borsos, Zoltan G. Pahi, Zsuzsanna Ujfaludi, Farkas Sukosd, Aliz Nikolenyi, Sarolta Banko, Gabriella Pankotai-Bodo, Orsolya Olah-Nemeth, Tibor Pankotai
Summary: Breast cancer, the most frequent cancer among women, is difficult to diagnose at an early stage. Serum biomarkers, particularly miRNAs, show potential as diagnostic tools for breast cancer. This study suggests that monitoring the expression of miR-15a+miR-16+miR-221 can improve the accuracy of breast cancer diagnosis.
Article
Food Science & Technology
Da-Bin Hwang, Yoojin Seo, Eunji Lee, Dong-hoon Won, Changuk Kim, MinHwa Kang, Young Jeon, Hyung-Sik Kim, Jun Won Park, Jun-Won Yun
Summary: Evaluation of tissue injury currently relies on serum biochemical analysis, which lacks tissue specificity and sensitivity. MicroRNAs (miRNAs) have been proposed as potential diagnostic tools to overcome these limitations, as tissue-enriched miRNAs can be detected in the blood after tissue injury. In this study, we screened specific patterns of altered hepatic miRNAs and their target mRNAs in cisplatin-injected rats, and identified novel liver-specific circulating miRNAs for drug-induced liver injury. Comparative analyses of miRNA expression changes in organs and serum were conducted, and miR-532-3p was identified as a potential serum biomarker for drug-induced liver injury.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Malgorzata Guz, Witold Jeleniewicz, Marek Cybulski
Summary: In recent years, the roles of non-coding RNAs (ncRNAs), particularly miRNAs, in cancer have been widely recognized. Aberrant expression of miRNAs is associated with various stages of cancer development, making them potential biomarkers and therapeutic targets. MiRNAs show promising applications in cancer diagnosis, prediction, and response to therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Emilio Nunez-Borque, Sergio Fernandez-Bravo, Pablo Rodriguez Del Rio, Lucia Palacio-Garcia, Angela Di Giannatale, Virginia Di Paolo, Angela Galardi, Marta Colletti, Luisa Pascucci, Jaime Tome-Amat, Javier Cuesta-Herranz, Maria Dolores Ibanez-Sandin, Jose Julio Laguna, Alberto Benito-Martin, Vanesa Esteban
Summary: This study investigates the involvement of miRNAs in anaphylactic reactions and their potential as biomarkers. The researchers found differential expression profiles of circulating miRNAs in patients with anaphylaxis, particularly miR-375-3p. Functional and molecular experiments demonstrated that miR-375-3p plays a negative role in the stability of the endothelial barrier. These findings provide insights into the molecular mechanisms underlying anaphylactic reactions and suggest the potential of miR-375-3p as a biomarker.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Simone Agostini, Roberta Mancuso, Andrea Saul Costa, Domenico Caputo, Mario Clerici
Summary: The detection of miR-J1-5p in urine of MS patients treated with Natalizumab could potentially serve as a biomarker to monitor JCPyV infection and better identify the risk of developing PML. The study found miR-J1-5p in the urine of 28% of patients, even in some cases where JCPyV DNA was not detected in urine or blood. This suggests that miR-J1-5p measurement could be valuable in assessing PML risk in Natalizumab-treated MS patients.
Article
Biochemistry & Molecular Biology
Atefeh Mohammadloo, Yazdan Asgari, Aghil Esmaeili-Bandboni, Mohammad Ali Mazloomi, Seyedeh Fatemeh Ghasemi, Sima Ameri, Seyed Rouhollah Miri, Shahin Hamzelou, Hamid Reza Mahmoudi, Ziba Veisi-Malekshahi
Summary: The study investigated the use of microRNAs as biomarkers for early diagnosis of melanoma. Through analysis of gene expression datasets and PCR experiments, it was found that miR-193b and miR-146b-3p were downregulated in melanoma patients' plasma, while miR-483-3p was upregulated. ROC curve analysis confirmed that miR-193b and miR-146b-3p had high discriminatory power, making them suitable for noninvasive early diagnosis of melanoma.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Toxicology
Chi Zhou, Yayuan Yang, Ling Hu, Xiangwen Meng, Xiying Guo, Min Lei, Zhanhong Ren, Qingjie Chen, Changhan Ouyang, Xiaosong Yang
Summary: This study investigated the role of miRNAs in the oxidative stress response of doxorubicin-induced cardiotoxicity. The findings suggest that miR-143 is involved in the regulation of oxidative stress and the development of cardiotoxicity, and it may serve as a potential biomarker and therapeutic target for doxorubicin-induced cardiotoxicity.
TOXICOLOGY IN VITRO
(2023)
Article
Endocrinology & Metabolism
Nina Morup, Rytis Stakaitis, Ailsa Maria Main, Ieva Golubickaite, Casper P. Hagen, Anders Juul, Kristian Almstrup
Summary: During the transition to puberty in boys, both the levels and bioactivity of miR-30b-5p increase, suggesting its role in the activation of the HPG axis. The levels of miR-155-5p also increase, while miR-200b-3p does not consistently change.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Chemistry, Medicinal
Yuji Nishiura, Akira Matsumura, Naotake Kobayashi, Atsuyuki Shimazaki, Shingo Sakamoto, Naohisa Kitade, Yutaka Tonomura, Akira Ino, Takayuki Okuno
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2018)
Article
Pathology
Kae Fujisawa, Takako Miyoshi, Yutaka Tonomura, Takeshi Izawa, Mitsuru Kuwamura, Mikinori Torii, Jyoji Yamate
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
(2011)
Article
Pathology
Emi Kashiwagi, Yutaka Tonomura, Chiaki Kondo, Koichi Masuno, Kae Fujisawa, Noriko Tsuchiya, Shuuichi Matsushima, Mikinori Torii, Nobuo Takasu, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
(2014)
Article
Toxicology
Y. Tonomura, E. Yamamoto, C. Kondo, A. Itoh, N. Tsuchiya, T. Uehara, T. Baba
HUMAN & EXPERIMENTAL TOXICOLOGY
(2009)
Article
Toxicology
Takeki Uehara, Akira Horinouchi, Yuji Morikawa, Yutaka Tonomura, Keiichi Minami, Atsushi Ono, Jyoji Yamate, Hiroshi Yamada, Yasuo Ohno, Tetsuro Urushidani
JOURNAL OF APPLIED TOXICOLOGY
(2014)
Article
Toxicology
Yoko Nishimura, Yuji Morikawa, Chiaki Kondo, Yutaka Tonomura, Ryou Fukushima, Mikinori Torii, Takeki Uehara
JOURNAL OF APPLIED TOXICOLOGY
(2013)
Article
Toxicology
Yutaka Tonomura, Yuki Kato, Hiroyuki Hanafusa, Yuji Morikawa, Keigo Matsuyama, Takeki Uehara, Motonobu Ueno, Mikinori Torii
JOURNAL OF APPLIED TOXICOLOGY
(2015)
Article
Biotechnology & Applied Microbiology
Shizu Hidema, Yutaka Tonomura, Shiori Date, Katsuhiko Nishimori
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
(2012)
Article
Pharmacology & Pharmacy
Yutaka Tonomura, Yoko Mori, Mikinori Torii, Takeki Uehara
Article
Pharmacology & Pharmacy
Yutaka Tonomura, Noriko Tsuchiya, Mikinori Torii, Takeki Uehara
Article
Pharmacology & Pharmacy
Yoko Mori, Chiaki Kondo, Yutaka Tonomura, Mikinori Tonii, Takeki Uehara
Article
Pharmacology & Pharmacy
Yutaka Tonomura, Takeki Uehara, Emi Yamamoto, Mikinori Torii, Mitsunobu Matsubara
Article
Pharmacology & Pharmacy
Yutaka Tonomura, Shuuichi Matsushima, Emi Kashiwagi, Kae Fujisawa, Shingo Takagi, Yoko Nishimura, Ryou Fukushima, Mikinori Torii, Mitsunobu Matsubara
Article
Pharmacology & Pharmacy
Yutaka Tonomura, Yuji Morikawa, Shingo Takagi, Mikinori Torii, Mitsunobu Matsubara