Article
Genetics & Heredity
Linxiang Feng, Zian Feng, Jie Hu, Jiahui Gao, Ang Li, Xiaodong He, Liu Liu, Zuojun Shen
Summary: In this study, high-throughput sequencing of miRNAs in plasma exosomes from lung adenocarcinoma patients and healthy individuals was performed. The results identified hsa-miR-4454 and hsa-miR-619-5p as potential biomarkers for the early diagnosis of lung adenocarcinoma.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
ShanHai Yu, Wei Li, XiangDing Liu, Hua Zhang, XiangYan Liu, Li -Wei Zhang
Summary: The study revealed that TRIM36 acts as an anti-oncogene in lung adenocarcinoma by inhibiting cell proliferation and promoting apoptosis. Low expression of TRIM36 is associated with poor prognosis in patients. Additionally, TRIM36 is negatively correlated with RAD51 and can promote RAD1 ubiquitination. TRIM36, RAD1, and hsa-miR-376a-5p may serve as prognostic indicators and potential therapeutic targets to increase radiation sensitivity in lung adenocarcinoma patients.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Chaonan Zhu, Shuai Wang, Maogen Zheng, Zhiquan Chen, Guochen Wang, Jun Ma, Bin Zhang, Wuhao Huang, Xiaoyan Sun, Changli Wang
Summary: The study reveals that miR-31-5p promotes cell progression in lung adenocarcinoma (LUAD) through the TNS1/p53 axis.
STRAHLENTHERAPIE UND ONKOLOGIE
(2022)
Article
Biochemistry & Molecular Biology
Mona A. Eldosoky, Reham Hammad, Asmaa A. Elmadbouly, Reda Badr Aglan, Sherihan G. Abdel-Hamid, Mohamed Alboraie, Donia Ahmed Hassan, Mohamed A. Shaheen, Areej Rushdi, Reem M. Ahmed, Alzahra Abdelbadea, Neamat A. Abdelmageed, Ahmed Elshafei, Elham Ali, Omaima I. Abo-Elkheir, Samy Zaky, Nadia M. Hamdy, Claude Lambert
Summary: Early HCC diagnosis is challenging, especially for AFP-negative cases. miRNA profiles may serve as potential molecular markers for HCC. This study aimed to evaluate the expression levels of four miRNAs (hsa-miR-21-5p, hsa-miR-155-5p, hsa-miR-192-5p, and hsa-miR-199a-5p) as biomarkers for HCC in CHCV patients with liver cirrhosis, particularly AFP-negative HCC cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Yuanxue Yang, Yun Zhang, Aiyu Wang, Ailing Duan, Chao Xue, Kaiyun Wang, Ming Zhao, Jianhua Zhang
Summary: This study investigated the resistance of Spodoptera frugiperda to insecticides and the regulatory roles of miRNAs. RNA-Seq analysis revealed that differentially expressed miRNAs play an important role in the insecticide resistance of S. frugiperda. Overexpression of specific miRNAs significantly increased the mortality of S. frugiperda to insecticides.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Wenyan Liao, Jun He, Cyrollah Disoma, Yi Hu, Junhua Li, Guodong Chen, Ying Sheng, Xinyu Cai, Chuanfu Li, Kai Cheng, Chunfen Yang, Yongxi Qin, Dong Han, Wu Wen, Chengming Ding, Mujun Li
Summary: This study demonstrated that hsa_circ_0107593 has low expression in cervical cancer tissues and cell lines, negatively correlated with tumor characteristics, and inhibits cell proliferation, migration, and invasion. It may serve as a diagnostic biomarker due to its tumor-suppressing activity by sponging hsa-miR-20a-5p, hsa-miR-93-5p, and hsa-miR-106b-5p in cervical cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zhenbo Tao, Shuying Zheng, Xin He, Jihan Sun, Canxia He, Lina Zhang
Summary: The study showed that the expression level of hsa_circ_0037897 was significantly higher in patients with essential hypertension compared to the control group, while hsa-miR-145-5p had lower expression. Combining hsa_circ_0037897 with hsa-miR-145-5p, BMI, and smoking increased the diagnostic value for essential hypertension.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Chemistry, Applied
Lujia Zhang, Li Dong, Liuqing Yang, Yinghua Luo, Fang Chen
Summary: Acrylamide, a potential carcinogen formed in high-heat carbohydrate-rich foods, induces mitochondrial dysfunction. The overexpression of miR-27a-5p regulates mitochondrial dysfunction, with Btf3 identified as its target gene. The miR-27a-5p-Btf3-ATM-p53 axis plays a crucial role in promoting AA-induced cell apoptosis by disrupting mitochondrial structure and function.
Article
Immunology
Yeuni Yu, Sohee Park, Hansong Lee, Eun Jung Kwon, Hae Ryoun Park, Yun Hak Kim, Seung-Geun Lee
Summary: This study aimed to develop potential biomarkers for rheumatoid arthritis (RA) by sequencing small non-coding RNA (sncRNA) in circulating exosomes. The expression levels of hsa-miR-335-5p and hsa-miR-486-5p were found to be higher in RA patients compared to healthy controls, while the expression of the SRSF4 gene was decreased. These findings suggest that circulating exosomal miRNAs and SRSF4 could serve as valuable biomarkers for RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Yu-kun Zheng, Zhong-shi Zhou, Guang-zhong Wang, Ji-yuan Tu, Huan-bo Cheng, Shang-zhi Ma, Chang Ke, Yan Wang, Qi-pan Jian, Yu-hang Shu, Xiao-wei Wu
Summary: This study found that inhibiting miR-122-5p can activate p53 and hinder the progression of the MVA pathway in non-small cell lung cancer (NSCLC). This leads to a decrease in cell proliferation and migration, and an increase in apoptosis. miR-122-5p interacts with p53 and is negatively correlated with its expression. Thus, miR-122-5p regulates NSCLC by targeting p53, offering potential molecular targets for targeted drug development.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Neslihan Coban, Aybike Sena Ozuynuk, Aycan Fahri Erkan, Filiz Guclu-Geyik, Berkay Ekici
Summary: This study identified distinct miRNA expression profiles in CAD patients compared to non-CAD individuals, with hsa-miR-18a-3p and hsa-miR-130b-5p potentially serving as biomarkers for CAD development and progression.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Samaneh Harimi, Behzad Khansarinejad, Farzaneh Fesahat, Mahdieh Mondanizadeh
Summary: Osteoblast differentiation is regulated by the hedgehog signaling pathway. This study identified two miRNAs that target the Ihh gene and found that they have an antithetical regulation during the differentiation process. These findings support the hypothesis that these miRNAs could target Ihh in human adipose tissue-derived mesenchymal stem cells.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Oncology
Xiaojing Liu, Na Niu, Pibao Li, Liping Zhai, Ke Xiao, Wendan Chen, Xuewei Zhuang
Summary: The study found that the expression of OGFRP1 was higher in NSCLC tissues than in normal lung tissue; siOGFRP1 inhibited the proliferation, migration, and invasion of A549 and H1299 cells to inhibit the progression of NSCLC, and OGFRP1 could directly interact with miR-4640-5p to regulate the development of NSCLC through the miR-4640-5p/eIF5A axis.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Li Ding, Yinan Feng, Longguang Li
Summary: This study elucidates the role of circular RNA 0001955 (circ_0001955) in the proliferation and apoptosis of non-small cell lung cancer (NSCLC) cells and its underlying mechanism. The results demonstrate that circ_0001955 is up-regulated in NSCLC tissues and cells, and its overexpression is associated with advanced tumor stage and lymph node metastasis. Overexpression of circ_0001955 enhances cell proliferation and inhibits apoptosis in NSCLC cells, while knockdown of circ_0001955 has the opposite effects. Circ_0001955 directly targets miR-769-5p and negatively regulates its expression. Furthermore, EGFR, a target gene of miR-769-5p, can be indirectly and positively regulated by circ_0001955. Correlation analysis reveals a negative correlation between circ_0001955 and miR-769-5p expression, while circ_0001955 is positively correlated with EGFR expression. Circ_0001955 promotes NSCLC cell proliferation and inhibits apoptosis by modulating the miR-769-5p/EGFR axis.
Article
Biotechnology & Applied Microbiology
Fei Jiang, Xueju Hu, Hongyong Cao, Xiaobing Shen
Summary: This study identified circRNA-0000081 as an up-regulated circular RNA in gastric cancer tissues and cells. The knockdown or overexpression of circRNA-0000081 affected the proliferation, migration, and invasion potential of gastric cancer. It was found that circRNA-0000081 promoted the function of gastric cancer by sponging hsa-miR-423-5p to influence PDPK1 expression.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)