Chondrocyte‐Specific RUNX2 Overexpression Accelerates Post‐traumatic Osteoarthritis Progression in Adult Mice

Runt-related transcription factor 2 (RUNX2) inhibits apoptosis of intestinal epithelial cells in Crohn’s disease

(2018) Liugen Gu et al.   PATHOLOGY RESEARCH AND PRACTICE

Transcriptional control of chondrocyte specification and differentiation

(2017) Chia-Feng Liu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Deletion of Runx2 in Articular Chondrocytes Decelerates the Progression of DMM-Induced Osteoarthritis in Adult Mice

(2017) Lifan Liao et al.   Scientific Reports

Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and anti-inflammatory in murine posttraumatic osteoarthritis

(2017) Qurratul-Ain Dar et al.   PLoS One

Glycogen Synthase Kinase-3β Inhibition Links Mitochondrial Dysfunction, Extracellular Matrix Remodelling and Terminal Differentiation in Chondrocytes

(2017) S. Guidotti et al.   Scientific Reports

CCN1 Regulates Chondrocyte Maturation and Cartilage Development

(2016) Yongchun Zhang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis

(2015) Zhaoyang Liu et al.   Science Signaling

A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis

(2015) Zhaoyang Liu et al.   Science Signaling

Identification of aPrg4-Expressing Articular Cartilage Progenitor Cell Population in Mice

(2015) Elena Kozhemyakina et al.   Arthritis & Rheumatology

Osteogenic fate of hypertrophic chondrocytes

(2014) Guan Yang et al.   CELL RESEARCH

Runx2 Regulates Endochondral Ossification Through Control of Chondrocyte Proliferation and Differentiation

(2014) Haiyan Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Resident mesenchymal progenitors of articular cartilage

(2014) Maria Elena Candela et al.   MATRIX BIOLOGY

Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation

(2014) L. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healing in Mice

(2014) Xin Zhou et al.   PLoS Genetics

Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis

(2014) Gary J. Litherland et al.   Arthritis & Rheumatology

Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients

(2013) Juan Fernández-Tajes et al.   ANNALS OF THE RHEUMATIC DISEASES

The genetic contribution to severe post-traumatic osteoarthritis

(2013) Ana M Valdes et al.   ANNALS OF THE RHEUMATIC DISEASES

Fibroblast Growth Factor 2 Drives Changes in Gene Expression Following Injury to Murine Cartilage In Vitro and In Vivo

(2013) Ka-Wing Chong et al.   ARTHRITIS AND RHEUMATISM

An analysis of skeletal development in osteoblast-specific and chondrocyte-specific runt-related transcription factor-2 (Runx2) knockout mice

(2013) Takeshi Takarada et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Development of the Endochondral Skeleton

(2013) F. Long et al.   Cold Spring Harbor Perspectives in Biology

Cartilage-specific RBPj -dependent and -independent Notch signals regulate cartilage and bone development

(2012) A. Kohn et al.   DEVELOPMENT

Sox9 Directs Hypertrophic Maturation and Blocks Osteoblast Differentiation of Growth Plate Chondrocytes

(2012) Peter Dy et al.   DEVELOPMENTAL CELL

Biomechanical stimulation of osteoblast gene expression requires phosphorylation of the RUNX2 transcription factor

(2012) Yan Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development

(2012) Debbie Y Dao et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study

(2012)   LANCET

Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis

(2012) M. C. Castano Betancourt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis

(2012) Mary B. Goldring   Therapeutic Advances in Musculoskeletal Disease

Indian hedgehog requires additional effectors besides Runx2 to induce osteoblast differentiation

(2011) Xiaolin Tu et al.   DEVELOPMENTAL BIOLOGY

C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes

(2011) Makoto Hirata et al.   HUMAN MOLECULAR GENETICS

Runx2 contributes to murine Col10a1 gene regulation through direct interaction with its cis-enhancer

(2011) Feifei Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Establishment of an index with increased sensitivity for assessing murine arthritis

(2011) Erik R. Sampson et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?

(2011) P.M. van der Kraan et al.   OSTEOARTHRITIS AND CARTILAGE

Teriparatide as a Chondroregenerative Therapy for Injury-Induced Osteoarthritis

(2011) E. R. Sampson et al.   Science Translational Medicine

SOX9 Governs Differentiation Stage-Specific Gene Expression in Growth Plate Chondrocytes via Direct Concomitant Transactivation and Repression

(2011) Victor Y. L. Leung et al.   PLoS Genetics

Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis

(2010) Ana M. Valdes et al.   ARTHRITIS AND RHEUMATISM

SOX9 determines RUNX2 transactivity by directing intracellular degradation

(2010) Aixin Cheng et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice

(2010) Matthew B. Greenblatt et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanical impact induces cartilage degradation via mitogen activated protein kinases

(2010) L. Ding et al.   OSTEOARTHRITIS AND CARTILAGE

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the rat

(2010) N. Gerwin et al.   OSTEOARTHRITIS AND CARTILAGE

Pomegranate extract inhibits the interleukin-1β-induced activation of MKK-3, p38α-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes

(2010) Zafar Rasheed et al.   ARTHRITIS RESEARCH & THERAPY

New developments in osteoarthritis. Prevention of injury-related knee osteoarthritis: opportunities for the primary and secondary prevention of knee osteoarthritis

(2010) Charles R Ratzlaff et al.   ARTHRITIS RESEARCH & THERAPY

Genetic Control of Bone Formation

(2009) Gerard Karsenty et al.   Annual Review of Cell and Developmental Biology

Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type x collagen gene

(2009) Akiro Higashikawa et al.   ARTHRITIS AND RHEUMATISM

Identification and Functional Characterization of ERK/MAPK Phosphorylation Sites in the Runx2 Transcription Factor

(2009) Chunxi Ge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-translational Regulation of Runx2 in Bone and Cartilage

(2009) J.H. Jonason et al.   JOURNAL OF DENTAL RESEARCH

Development of osteoarthritic features in estrogen receptor knockout mice

(2009) Y.H. Sniekers et al.   OSTEOARTHRITIS AND CARTILAGE

Modulation of Runx2 Activity by Estrogen Receptor-α: Implications for Osteoporosis and Breast Cancer

(2008) Omar Khalid et al.   ENDOCRINOLOGY

Regulation of chondrogenesis and chondrocyte differentiation by stress

(2008) Michael J. Zuscik et al.   JOURNAL OF CLINICAL INVESTIGATION

L-Sox5 and Sox6 Drive Expression of the Aggrecan Gene in Cartilage by Securing Binding of Sox9 to a Far-Upstream Enhancer

(2008) Y. Han et al.   MOLECULAR AND CELLULAR BIOLOGY

Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis

(2008) R A Eliseev et al.   ONCOGENE

Animal models for osteoarthritis: the effect of ovariectomy and estrogen treatment – a systematic approach

(2008) Y.H. Sniekers et al.   OSTEOARTHRITIS AND CARTILAGE