Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease

An Important Role for Type III Interferon (IFN- /IL-28) in TLR-Induced Antiviral Activity

(2014) N. Ank et al.   JOURNAL OF IMMUNOLOGY

Protective Immunity to Systemic Infection with Attenuated Salmonella enterica serovar Enteritidis in the Absence of IL-12 Is Associated with IL-23-Dependent IL-22, but Not IL-17

(2014) S. M. Schulz et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-27 Is a Potent Inducer of IL-10 but Not FoxP3 in Murine T Cells

(2014) M. Batten et al.   JOURNAL OF IMMUNOLOGY

Chronically Inflamed Human Tissues Are Infiltrated by Highly Differentiated Th17 Lymphocytes

(2014) J. Pene et al.   JOURNAL OF IMMUNOLOGY

Distinct, Specific IL-17- and IL-22-Producing CD4+ T Cell Subsets Contribute to the Human Anti-Mycobacterial Immune Response

(2014) T. J. Scriba et al.   JOURNAL OF IMMUNOLOGY

Activation of epithelial STAT3 regulates intestinal homeostasis

(2011) Clemens Neufert et al.   CELL CYCLE

Interleukin-23 promotes Th17 differentiation by inhibiting T-bet and FoxP3 and is required for elevation of interleukin-22, but not interleukin-21, in autoimmune experimental arthritis

(2010) Adriana M. C. Mus et al.   ARTHRITIS AND RHEUMATISM

Genome-wide profiling of methylated promoters in pancreatic adenocarcinoma: Defining the pancreatic cancer epigenome

(2010) Paul G. Corn   CANCER BIOLOGY & THERAPY

Structure and function of interleukin-22 and other members of the interleukin-10 family

(2010) Daniela Barretto Barbosa Trivella et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Interleukin-22 is a negative regulator of the allergic response

(2010) Bruno Schnyder et al.   CYTOKINE

Regulation of human Th9 differentiation by type I interferons and IL-21

(2010) Michael T Wong et al.   IMMUNOLOGY AND CELL BIOLOGY

Natural killer receptors: the burden of a name: Figure 1.

(2010) Henrique Veiga-Fernandes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I

(2010) Anne Puel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human NKp44+IL-22+cells and LTi-like cells constitute a stable RORC+lineage distinct from conventional natural killer cells

(2010) Natasha K. Crellin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-7 and IL-15 independently program the differentiation of intestinal CD3−NKp46+cell subsets from Id2-dependent precursors

(2010) Naoko Satoh-Takayama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines

(2010) Kai Kisand et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22

(2010) Ling Yang et al.   JOURNAL OF HEPATOLOGY

Th17 Cells Are the Dominant T Cell Subtype Primed by Shigella flexneri Mediating Protective Immunity

(2010) Gernot Sellge et al.   JOURNAL OF IMMUNOLOGY

IL-24 Transgenic Mice: In Vivo Evidence of Overlapping Functions for IL-20, IL-22, and IL-24 in the Epidermis

(2010) Miao He et al.   JOURNAL OF IMMUNOLOGY

Redundant and Pathogenic Roles for IL-22 in Mycobacterial, Protozoan, and Helminth Infections

(2010) M. S. Wilson et al.   JOURNAL OF IMMUNOLOGY

Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1 , and TNF-  Recapitulates Some Features of Psoriasis

(2010) K. Guilloteau et al.   JOURNAL OF IMMUNOLOGY

Assessment of the Psoriatic Transcriptome in a Large Sample: Additional Regulated Genes and Comparisons with In Vitro Models

(2010) Johann E. Gudjonsson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Involvement of the IL-22/REG Iα axis in ulcerative colitis

(2010) Akira Sekikawa et al.   LABORATORY INVESTIGATION

IL-22 defines a novel immune pathway of antifungal resistance

(2010) A De Luca et al.   Mucosal Immunology

IκBζ regulates TH17 development by cooperating with ROR nuclear receptors

(2010) Kazuo Okamoto et al.   NATURE

Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor

(2010) M. S. Alam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lineage Relationship Analysis of RORγt+Innate Lymphoid Cells

(2010) Shinichiro Sawa et al.   SCIENCE

Structure and Mechanism of Receptor Sharing by the IL-10R2 Common Chain

(2010) Sung-il Yoon et al.   STRUCTURE

IL-22 is involved in liver regeneration after hepatectomy

(2009) Xiaodan Ren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Interferon Lambda as a Potential New Therapeutic for Hepatitis C

(2009) Dennis M. Miller et al.   Annals of the New York Academy of Sciences

Decreased plasma IL22 levels, but not increased IL17 and IL23 levels, correlate with disease activity in patients with systemic lupus erythematosus

(2009) F Cheng et al.   ANNALS OF THE RHEUMATIC DISEASES

Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis

(2009) Hui Shen et al.   ARTHRITIS AND RHEUMATISM

Proinflammatory role of the Th17 cytokine interleukin-22 in collagen-induced arthritis in C57BL/6 mice

(2009) Lies Geboes et al.   ARTHRITIS AND RHEUMATISM

Interleukin-20 plays a critical role in maintenance and development of psoriasis in the human xenograft transplantation model

(2009) K. Stenderup et al.   BRITISH JOURNAL OF DERMATOLOGY

T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients

(2009) A. Di Stefano et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Cloning of a novel interleukin (IL)-20-like gene in rainbow trout Oncorhynchus mykiss gives an insight into the evolution of the IL-10 family

(2009) Tiehui Wang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Memory IL‐22‐producing CD4+T cells specific forCandida albicansare present in humans

(2009) Yun Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-24 protects againstSalmonella typhimuriuminfection by stimulating early neutrophil Th1 cytokine production, which in turn activates CD8+T cells

(2009) Yunfeng Ma et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytesviaincreased IL-22 receptor expression

(2009) Mikiko Tohyama et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: A novel immunological cascade with potential relevance in psoriasis

(2009) Kerstin Wolk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22

(2009) Patricia Ribeiro de Moura et al.   FEBS LETTERS

Despite IFN-λ receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines

(2009) K Witte et al.   GENES AND IMMUNITY

Interleukin-10 Production by Th1 Cells Requires Interleukin-12-Induced STAT4 Transcription Factor and ERK MAP Kinase Activation by High Antigen Dose

(2009) Margarida Saraiva et al.   IMMUNITY

Interleukin-22-Producing Natural Killer Cells and Lymphoid Tissue Inducer-like Cells in Mucosal Immunity

(2009) Marco Colonna   IMMUNITY

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

(2009) Ethan M. Shevach   IMMUNITY

Control of Regulatory T Cell Lineage Commitment and Maintenance

(2009) Steven Z. Josefowicz et al.   IMMUNITY

Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals

(2009) Bruno Martin et al.   IMMUNITY

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

(2009) Caroline E. Sutton et al.   IMMUNITY

Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation

(2009) Craig L. Maynard et al.   IMMUNOLOGICAL REVIEWS

Suppressive functions of activated B cells in autoimmune diseases reveal the dual roles of Toll-like receptors in immunity

(2009) Vicky Lampropoulou et al.   IMMUNOLOGICAL REVIEWS

Interleukin-19 protects mice from innate-mediated colonic inflammation

(2009) Yasu-Taka Azuma et al.   INFLAMMATORY BOWEL DISEASES

Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis

(2009) S. Siegemund et al.   INTERNATIONAL IMMUNOLOGY

New Activation Modus of STAT3

(2009) Laure Dumoutier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interferon-λ Is Functionally an Interferon but Structurally Related to the Interleukin-10 Family

(2009) Hans Henrik Gad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin (IL)-23 mediatesToxoplasma gondii–induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17

(2009) Melba Muñoz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation

(2009) Melanie A. Kleinschek et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis

(2009) Heather R. Conti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

(2009) Geethanjali Pickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10–secreting Th1 cells

(2009) Leona Gabryšová et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Plasmacytoid Dendritic Cells Induce IL-10 Production in T Cells via the Delta-Like-4/Notch Axis

(2009) N. Kassner et al.   JOURNAL OF IMMUNOLOGY

IL-27 Regulates IL-10 and IL-17 from CD4+ Cells in Nonhealing Leishmania major Infection

(2009) C. F. Anderson et al.   JOURNAL OF IMMUNOLOGY

The Natural Cytotoxicity Receptor NKp46 Is Dispensable for IL-22-Mediated Innate Intestinal Immune Defense against Citrobacter rodentium

(2009) N. Satoh-Takayama et al.   JOURNAL OF IMMUNOLOGY

Regulation of T Cell Activation by Notch Ligand, DLL4, Promotes IL-17 Production and Rorc Activation

(2009) S. Mukherjee et al.   JOURNAL OF IMMUNOLOGY

IL-22 Produced by Human NK Cells Inhibits Growth of Mycobacterium tuberculosis by Enhancing Phagolysosomal Fusion

(2009) R. Dhiman et al.   JOURNAL OF IMMUNOLOGY

IL-27 Is a Key Regulator of IL-10 and IL-17 Production by Human CD4+ T Cells

(2009) G. Murugaiyan et al.   JOURNAL OF IMMUNOLOGY

c-Maf Regulates IL-10 Expression during Th17 Polarization

(2009) Jiangnan Xu et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-27 Induces the Transcription Factor c-Maf, Cytokine IL-21, and the Costimulatory Receptor ICOS that Coordinately Act Together to Promote Differentiation of IL-10-Producing Tr1 Cells

(2009) C. Pot et al.   JOURNAL OF IMMUNOLOGY

IL-22-Dependent Attenuation of T Cell-Dependent (ConA) Hepatitis in Herpes Virus Entry Mediator Deficiency

(2009) C. Wahl et al.   JOURNAL OF IMMUNOLOGY

Circulating Th17, Th22, and Th1 Cells Are Increased in Psoriasis

(2009) Shinji Kagami et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-γ are not

(2009) Kerstin Wolk et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

(2009) Dongliang Ge et al.   NATURE

Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

(2009) David L. Thomas et al.   NATURE

IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy

(2009) Vijayaprakash Suppiah et al.   NATURE GENETICS

Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C

(2009) Yasuhito Tanaka et al.   NATURE GENETICS

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

(2009) Sara Trifari et al.   NATURE IMMUNOLOGY

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells

(2009) Thomas Duhen et al.   NATURE IMMUNOLOGY

The Role of Genomic Data in the Discovery, Annotation and Evolutionary Interpretation of the Interferon-Lambda Family

(2009) Brian A. Fox et al.   PLoS One

Expression of IL-10 family cytokines in rheumatoid arthritis: elevated levels of IL-19 in the joints

(2009) T Alanärä et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Interleukin-20 targets renal mesangial cells and is associated with lupus nephritis

(2008) Hsing-Hui Li et al.   CLINICAL IMMUNOLOGY

Involvement of ERK-1/2 in IL-21-induced cytokine production in leukemia cells and human monocytes

(2008) C.F. Fuqua et al.   CYTOKINE

Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism

(2008) Lucas Bleicher et al.   FEBS LETTERS

The role of the novel Th17 cytokine IL-26 in intestinal inflammation

(2008) J Dambacher et al.   GUT

Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease

(2008) Lauren A. Zenewicz et al.   IMMUNITY

The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation

(2008) Wenjun Ouyang et al.   IMMUNITY

Microbial Flora Drives Interleukin 22 Production in Intestinal NKp46+ Cells that Provide Innate Mucosal Immune Defense

(2008) Naoko Satoh-Takayama et al.   IMMUNITY

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

IL-24 modulates IFN-γ expression in patients with tuberculosis

(2008) Bo Wu et al.   IMMUNOLOGY LETTERS

Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4/IL-13: Important implications in asthma

(2008) Fei Huang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interleukin-29 Functions Cooperatively with Interferon to Induce Antiviral Gene Expression and Inhibit Hepatitis C Virus Replication

(2008) Nicole E. Pagliaccetti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Serine Protease Marapsin Is Expressed in Stratified Squamous Epithelia and Is Up-regulated in the Hyperproliferative Epidermis of Psoriasis and Regenerating Wounds

(2008) Wei Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-24: a classic cytokine and/or a potential cure for cancer?

(2008) S. Kreis et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22

(2008) Hiroaki Takatori et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells

(2008) Marc Veldhoen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Patients with Chronic Mucocutaneous Candidiasis Exhibit Reduced Production of Th17-Associated Cytokines IL-17 and IL-22

(2008) Kilian Eyerich et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Role of STAT3 in glucocorticoid-induced expression of the human IL-10 gene

(2008) Claudia Unterberger et al.   MOLECULAR IMMUNOLOGY

IL-22 in mucosal immunity

(2008) W Ouyang et al.   Mucosal Immunology

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

(2008) Marina Cella et al.   NATURE

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

(2008) Francisco J. Quintana et al.   NATURE

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

(2008) Andre Franke et al.   NATURE GENETICS

Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin

(2008) Carmelo Luci et al.   NATURE IMMUNOLOGY

RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells

(2008) Stephanie L Sanos et al.   NATURE IMMUNOLOGY

Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells

(2008) Tom Cupedo et al.   NATURE IMMUNOLOGY

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

(2008) Marc Veldhoen et al.   NATURE IMMUNOLOGY

IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells

(2008) Valérie Dardalhon et al.   NATURE IMMUNOLOGY

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY

IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia

(2008) Shean J Aujla et al.   NATURE MEDICINE

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE

Notch regulates IL-10 production by T helper 1 cells

(2008) S. Rutz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype

(2008) M. Huber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells

(2008) A. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of IL-19 and its receptors in RA: potential role for synovial hyperplasia formation

(2008) N. Sakurai et al.   RHEUMATOLOGY

Structure of IL-22 Bound to Its High-Affinity IL-22R1 Chain

(2008) Brandi C. Jones et al.   STRUCTURE

Interleukin-22 Deficiency Accelerates the Rejection of Full Major Histocompatibility Complex-Disparate Heart Allografts

(2008) P. Kapessidou et al.   TRANSPLANTATION PROCEEDINGS

Interferon-λ Contributes to Innate Immunity of Mice against Influenza A Virus but Not against Hepatotropic Viruses

(2008) Markus Mordstein et al.   PLoS Pathogens

IFN-Lambda (IFN-λ) Is Expressed in a Tissue-Dependent Fashion and Primarily Acts on Epithelial Cells In Vivo

(2008) Caroline Sommereyns et al.   PLoS Pathogens

Structural Biology of Shared Cytokine Receptors

(2007) Xinquan Wang et al.   Annual Review of Immunology

Interleukin-22 Forms Dimers that are Recognized by Two Interleukin-22R1 Receptor Chains

(2007) Mario de Oliveira Neto et al.   BIOPHYSICAL JOURNAL

The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy

(2007) Tue Wenzel Kragstrup et al.   CYTOKINE

Linking genetic susceptibility to Crohnʼs disease with Th17 cell function: IL-22 serum levels are increased in Crohnʼs disease and correlate with disease activity and IL23R genotype status

(2007) Silke Schmechel et al.   INFLAMMATORY BOWEL DISEASES

IL-10 and the resolution of infections

(2007) CM Filippi et al.   JOURNAL OF PATHOLOGY