The multiple faces of RAGE – opportunities for therapeutic intervention in aging and chronic disease

Isolevuglandin-Type Lipid Aldehydes Induce the Inflammatory Response of Macrophages by Modifying Phosphatidylethanolamines and Activating the Receptor for Advanced Glycation Endproducts

(2015) Lilu Guo et al.   ANTIOXIDANTS & REDOX SIGNALING

Deoxycholic acid-modified polyethylenimine based nanocarriers for RAGE siRNA therapy in acute myocardial infarction

(2015) Sook Hee Ku et al.   ARCHIVES OF PHARMACAL RESEARCH

S100A12 and RAGE Expression in Human Bladder Transitional Cell Carcinoma: a Role for the Ligand/RAGE Axis in Tumor Progression?

(2015) Hossein Khorramdelazad et al.   Asian Pacific Journal of Cancer Prevention

Role of receptor for advanced glycation end products in the complication and progression of various types of cancers

(2015) Parth Malik et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

RAGE Mediates S100A7-Induced Breast Cancer Growth and Metastasis by Modulating the Tumor Microenvironment

(2015) M. W. Nasser et al.   CANCER RESEARCH

Emerging Targets for Therapeutic Development in Diabetes and Its Complications: The RAGE Signaling Pathway

(2015) EMS Litwinoff et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Role of the receptor for advanced glycation endproducts (RAGE) in retinal vasodegenerative pathology during diabetes in mice

(2015) Carmel M. McVicar et al.   DIABETOLOGIA

Gemigliptin improves renal function and attenuates podocyte injury in mice with diabetic nephropathy

(2015) Eunsoo Jung et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Receptor mediated disruption of retinal pigment epithelium function in acute glycated-albumin exposure

(2015) Mohammad Dahrouj et al.   EXPERIMENTAL EYE RESEARCH

Receptor for advanced glycation endproduct modulators: a new therapeutic target in Alzheimer’s disease

(2015) Douglas Walker et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Empagliflozin, an Inhibitor of Sodium-Glucose Cotransporter 2 Exerts Anti-Inflammatory and Antifibrotic Effects on Experimental Diabetic Nephropathy Partly by Suppressing AGEs-Receptor Axis

(2015) A. Ojima et al.   HORMONE AND METABOLIC RESEARCH

Redox status of high-mobility group box 1 performs a dual role in angiogenesis of colorectal carcinoma

(2015) Lingyin Zhu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

S100A8 is a Novel Therapeutic Target for Anaplastic Thyroid Carcinoma

(2015) Ashley N. Reeb et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Elevated Serum Advanced Glycation Endproducts in Obese Indicate Risk for the Metabolic Syndrome: A Link Between Healthy and Unhealthy Obesity?

(2015) Jaime Uribarri et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Deletion of Receptor for Advanced Glycation End Products Exacerbates Lymphoproliferative Syndrome and Lupus Nephritis in B6-MRL Fas lpr/j Mice

(2015) Antoine Goury et al.   JOURNAL OF IMMUNOLOGY

Dietary CML-enriched protein induces functional arterial aging in a RAGE-dependent manner in mice

(2015) Nicolas Grossin et al.   MOLECULAR NUTRITION & FOOD RESEARCH

RAGE Mediates the Pro-Migratory Response of Extracellular S100A4 in Human Thyroid Cancer Cells

(2015) Manoj Reddy Medapati et al.   THYROID

Pathway-based gene signatures predicting clinical outcome of lung adenocarcinoma

(2015) Ya-Hsuan Chang et al.   Scientific Reports

Randomized Pilot Trial of Bariatric Surgery Versus Intensive Medical Weight Management on Diabetes Remission in Type 2 Diabetic Patients Who Do NOT Meet NIH Criteria for Surgery and the Role of Soluble RAGE as a Novel Biomarker of Success

(2014) Manish Parikh et al.   ANNALS OF SURGERY

N ε -(Carboxymethyl)lysine-Receptor for Advanced Glycation End Product Axis Is a Key Modulator of Obesity-Induced Dysregulation of Adipokine Expression and Insulin Resistance

(2014) Katrien H.J. Gaens et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Therapeutic targets for rheumatoid arthritis: Progress and promises

(2014) Abdullah Alghasham et al.   AUTOIMMUNITY

RAGE Expression in Tumor-Associated Macrophages Promotes Angiogenesis in Glioma

(2014) X. Chen et al.   CANCER RESEARCH

Role of bone-marrow- and non-bone-marrow-derived receptor for advanced glycation end-products (RAGE) in a mouse model of diabetes-associated atherosclerosis

(2014) Christine Koulis et al.   CLINICAL SCIENCE

RAGE Regulates the Metabolic and Inflammatory Response to High-Fat Feeding in Mice

(2014) Fei Song et al.   DIABETES

Deletion of bone-marrow-derived receptor for AGEs (RAGE) improves renal function in an experimental mouse model of diabetes

(2014) Greg Tesch et al.   DIABETOLOGIA

Contribution of receptor for advanced glycation end products to vasculature-protecting effects of exercise training in aged rats

(2014) Qi Gu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

RAGE Ligation Affects T Cell Activation and Controls T Cell Differentiation

(2014) Y. Chen et al.   JOURNAL OF IMMUNOLOGY

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Clinical trial of an inhibitor of RAGE-A  interactions in Alzheimer disease

(2014) D. Galasko et al.   NEUROLOGY

S100A8 Contributes to Drug Resistance by Promoting Autophagy in Leukemia Cells

(2014) Minghua Yang et al.   PLoS One

Ramipril inhibits AGE-RAGE-induced matrix metalloproteinase-2 activation in experimental diabetic nephropathy

(2014) Kei Fukami et al.   Diabetology & Metabolic Syndrome

BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease

(2014) Robert Vassar   Alzheimers Research & Therapy

Simvastatin suppresses vascular inflammation and atherosclerosis in ApoE−/− mice by downregulating the HMGB1-RAGE axis

(2013) Ming Liu et al.   ACTA PHARMACOLOGICA SINICA

Systemic Soluble Receptor for Advanced Glycation Endproducts Is a Biomarker of Emphysema and Associated with AGER Genetic Variants in Patients with Chronic Obstructive Pulmonary Disease

(2013) Donavan T. Cheng et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hypoxia Promotes Danger-mediated Inflammation via Receptor for Advanced Glycation End Products in Cystic Fibrosis

(2013) Rossana G. Iannitti et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

RAGE-binding S100A8/A9 promotes the migration and invasion of human breast cancer cells through actin polymerization and epithelial–mesenchymal transition

(2013) Chonggao Yin et al.   BREAST CANCER RESEARCH AND TREATMENT

S100B Promotes Glioma Growth through Chemoattraction of Myeloid-Derived Macrophages

(2013) H. Wang et al.   CLINICAL CANCER RESEARCH

Critical role of RAGE in lung physiology and tumorigenesis: a potential target of therapeutic intervention?

(2013) Evangelos Marinakis et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Radical Roles for RAGE in the Pathogenesis of Oxidative Stress in Cardiovascular Diseases and Beyond

(2013) Gurdip Daffu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Streptozotocin-induced diabetes increases amyloid plaque deposition in AD transgenic mice through modulating AGEs/RAGE/NF-κB pathway

(2013) Xu Wang et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

The role of S100B in the interaction between adipocytes and macrophages

(2013) Atsushi Fujiya et al.   Obesity

Combinatorial Library of Improved Peptide Aptamers, CLIPs to Inhibit RAGE Signal Transduction in Mammalian Cells

(2013) Sergey Reverdatto et al.   PLoS One

Unlocking the biology of RAGE in diabetic microvascular complications

(2013) Michaele B. Manigrasso et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

RAGE in tissue homeostasis, repair and regeneration

(2012) Guglielmo Sorci et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Formin mDia1 Mediates Vascular Remodeling via Integration of Oxidative and Signal Transduction Pathways

(2012) Fatouma Touré et al.   CIRCULATION RESEARCH

Receptor for advanced glycation end products in bacterial infection

(2012) Eirini Christaki et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Alagebrium Reduces Glomerular Fibrogenesis and Inflammation Beyond Preventing RAGE Activation in Diabetic Apolipoprotein E Knockout Mice

(2012) A. M. D. Watson et al.   DIABETES

RAGE Deficiency Improves Postinjury Sciatic Nerve Regeneration in Type 1 Diabetic Mice

(2012) J. K. Juranek et al.   DIABETES

High-mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases

(2012) Wei Yan et al.   HEPATOLOGY

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Lysophosphatidic acid targets vascular and oncogenic pathways via RAGE signaling

(2012) Vivek Rai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The diverse ligand repertoire of the receptor for advanced glycation endproducts and pathways to the complications of diabetes

(2012) Ravichandran Ramasamy et al.   VASCULAR PHARMACOLOGY

Targeting receptor for advanced glycation end products (RAGE) expression induces apoptosis and inhibits prostate tumor growth

(2011) Indira Elangovan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Psoriasin (S100A7) increases the expression of ROS and VEGF and acts through RAGE to promote endothelial cell proliferation

(2011) Emman Shubbar et al.   BREAST CANCER RESEARCH AND TREATMENT

S100A7 Enhances Mammary Tumorigenesis through Upregulation of Inflammatory Pathways

(2011) M. W. Nasser et al.   CANCER RESEARCH

Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1/2 and Akt and nuclear translocation of NF-κB

(2011) Marco Tafani et al.   CARCINOGENESIS

Total Soluble and Endogenous Secretory Receptor for Advanced Glycation End Products as Predictive Biomarkers of Coronary Heart Disease Risk in Patients With Type 2 Diabetes: An Analysis From the CARDS Trial

(2011) H. M. Colhoun et al.   DIABETES

Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells

(2011) Mei He et al.   EMBO REPORTS

High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and Receptor for Advanced Glycation End Products

(2011) Andréy Mazarati et al.   EXPERIMENTAL NEUROLOGY

Opposing roles of RAGE and Myd88 signaling in extensive liver resection

(2011) Shan Zeng et al.   FASEB JOURNAL

S100B Protein Stimulates Microglia Migration via RAGE-dependent Up-regulation of Chemokine Expression and Release

(2011) Roberta Bianchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signal Transduction in Receptor for Advanced Glycation End Products (RAGE)

(2011) Vivek Rai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Aβ-receptor for advanced glycation endproducts interaction in oxidative stress and cytosolic phospholipase A2 activation in astrocytes and cerebral endothelial cells

(2011) S. Askarova et al.   NEUROSCIENCE

S100A14 Stimulates Cell Proliferation and Induces Cell Apoptosis at Different Concentrations via Receptor for Advanced Glycation End Products (RAGE)

(2011) Qing'e Jin et al.   PLoS One

Lack of the Receptor for Advanced Glycation End-Products Attenuates E. coli Pneumonia in Mice

(2011) Lasse Ramsgaard et al.   PLoS One

Advanced Glycation End Product Recognition by the Receptor for AGEs

(2011) Jing Xue et al.   STRUCTURE

Aldose Reductase and AGE-RAGE pathways: central roles in the pathogenesis of vascular dysfunction in aging rats

(2010) Kellie McCormick Hallam et al.   AGING CELL

Nifedipine inhibits advanced glycation end products (AGEs) and their receptor (RAGE) interaction-mediated proximal tubular cell injury via peroxisome proliferator-activated receptor-gamma activation

(2010) Takanori Matsui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of the ROCK1 Branch of the Transforming Growth Factor-β Pathway Contributes to RAGE-Dependent Acceleration of Atherosclerosis in Diabetic ApoE-Null Mice

(2010) De-xiu Bu et al.   CIRCULATION RESEARCH

Deletion of the Receptor for Advanced Glycation End Products Reduces Glomerulosclerosis and Preserves Renal Function in the Diabetic OVE26 Mouse

(2010) Nina Reiniger et al.   DIABETES

Hyperglycaemia-induced pro-inflammatory responses by retinal Müller glia are regulated by the receptor for advanced glycation end-products (RAGE)

(2010) H. Zong et al.   DIABETOLOGIA

The 1.5 Å Crystal Structure of Human Receptor for Advanced Glycation Endproducts (RAGE) Ectodomains Reveals Unique Features Determining Ligand Binding

(2010) HaJeung Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Advanced Glycation End Product (AGE)-Receptor for AGE (RAGE) Signaling and Up-regulation of Egr-1 in Hypoxic Macrophages

(2010) Yunlu Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of the Receptor for Advanced Glycation End-Products in a Murine Model of Silicosis

(2010) Lasse Ramsgaard et al.   PLoS One

RAGE Modulates Hypoxia/Reoxygenation Injury in Adult Murine Cardiomyocytes via JNK and GSK-3β Signaling Pathways

(2010) Linshan Shang et al.   PLoS One

Structural Basis for Ligand Recognition and Activation of RAGE

(2010) Michael Koch et al.   STRUCTURE

Plasma Levels of Receptor for Advanced Glycation End Products, Blood Transfusion, and Risk of Primary Graft Dysfunction

(2009) Jason D. Christie et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

AGE and their receptor RAGE in systemic autoimmune diseases: An inflammation propagating factor contributing to accelerated atherosclerosis

(2009) Hans L. A. Nienhuis et al.   AUTOIMMUNITY

RAGE mediates oxidized LDL-induced pro-inflammatory effects and atherosclerosis in non-diabetic LDL receptor-deficient mice

(2009) L. Sun et al.   CARDIOVASCULAR RESEARCH

RAGE regulates BACE1 and Aβ generation via NFAT1 activation in Alzheimer’s disease animal model

(2009) H. J. Cho et al.   FASEB JOURNAL

RAGE-dependent signaling in microglia contributes to neuroinflammation, Aβ accumulation, and impaired learning/memory in a mouse model of Alzheimer’s disease

(2009) Fang Fang et al.   FASEB JOURNAL

Soluble forms of RAGE in internal medicine

(2009) Natale Vazzana et al.   Internal and Emergency Medicine

Association between the RAGE G82S polymorphism and Alzheimer’s disease

(2009) Keshen Li et al.   JOURNAL OF NEURAL TRANSMISSION

Soluble receptor for advanced glycation end products: a new biomarker in diagnosis and prognosis of chronic inflammatory diseases

(2009) H. Maillard-Lefebvre et al.   RHEUMATOLOGY

Atherosclerosis in autoimmune diseases

(2009) Eiji Matsuura et al.   Current Rheumatology Reports

A neutralizing antibody against receptor for advanced glycation end products (RAGE) reduces atherosclerosis in uremic mice

(2008) Susanne Bro et al.   ATHEROSCLEROSIS

Formins in cell signaling

(2008) Kevin G. Young et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease

(2008) Miles C. Miller et al.   BRAIN RESEARCH

Oxygen Deprivation Triggers Upregulation of Early Growth Response-1 by the Receptor for Advanced Glycation End Products

(2008) Jong Sun Chang et al.   CIRCULATION RESEARCH

The Role of the Cell Surface LRP and Soluble LRP in Blood-Brain Barrier Aβ Clearance in Alzheimers Disease

(2008) R. Deane et al.   CURRENT PHARMACEUTICAL DESIGN

Role of Advanced Glycation End Products in Diabetic Neuropathy

(2008) Kazuhiro Sugimoto et al.   CURRENT PHARMACEUTICAL DESIGN

Receptor for Advanced Glycation End Products (RAGE) Deficiency Attenuates the Development of Atherosclerosis in Diabetes

(2008) A. Soro-Paavonen et al.   DIABETES

A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)

(2008) Angela Raucci et al.   FASEB JOURNAL

Receptor for Advanced Glycation End Products Is Subjected to Protein Ectodomain Shedding by Metalloproteinases

(2008) Ling Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of the RAGE Cytoplasmic Domain with Diaphanous-1 Is Required for Ligand-stimulated Cellular Migration through Activation of Rac1 and Cdc42

(2008) Barry I. Hudson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE–/– mice

(2008) Evis Harja et al.   JOURNAL OF CLINICAL INVESTIGATION

RAGE signaling sustains inflammation and promotes tumor development

(2008) Christoffer Gebhardt et al.   JOURNAL OF EXPERIMENTAL MEDICINE