S100A8 and S100A9: DAMPs at the Crossroads between Innate Immunity, Traditional Risk Factors, and Cardiovascular Disease

Serum S100A12 Levels Are Correlated With the Presence and Severity of Coronary Artery Disease in Patients With Type 2 Diabetes Mellitus

(2016) Peng Zhao et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Chemotactic Activity of S100A7 (Psoriasin) Is Mediated by the Receptor for Advanced Glycation End Products and Potentiates Inflammation with Highly Homologous but Functionally Distinct S100A15

(2014) R. Wolf et al.   JOURNAL OF IMMUNOLOGY

Leukocyte-Specific CCL3 Deficiency Inhibits Atherosclerotic Lesion Development by Affecting Neutrophil Accumulation

(2013) Saskia C.A. de Jager et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Plasma S100A8/A9 Correlates With Blood Neutrophil Counts, Traditional Risk Factors, and Cardiovascular Disease in Middle-Aged Healthy Individuals

(2013) Ovidiu S. Cotoi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Beneficial effects of quinoline-3-carboxamide (ABR-215757) on atherosclerotic plaque morphology in S100A12 transgenic ApoE null mice

(2013) Ling Yan et al.   ATHEROSCLEROSIS

Hyperglycemia Promotes Myelopoiesis and Impairs the Resolution of Atherosclerosis

(2013) Prabhakara R. Nagareddy et al.   Cell Metabolism

Clinical aspects of autoimmune rheumatic diseases

(2013) Fiona Goldblatt et al.   LANCET

Increased serum levels of S100A8/A9 and S100A12 are associated with cardiovascular disease in patients with inactive systemic lupus erythematosus

(2013) H. Tyden et al.   RHEUMATOLOGY

The Toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis

(2012) Dirk Holzinger et al.   ANNALS OF THE RHEUMATIC DISEASES

In Vivo Targeting of Inflammation-Associated Myeloid-Related Protein 8/14 Via Gadolinium Immunonanoparticles

(2012) Andrei Maiseyeu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A Role for MRP8 in in stent restenosis in diabetes

(2012) A. Stocca et al.   ATHEROSCLEROSIS

S100A8/A9 aggravates post-ischemic heart failure through activation of RAGE-dependent NF-κB signaling

(2012) H. Christian Volz et al.   BASIC RESEARCH IN CARDIOLOGY

High circulating levels of S100A8/A9 complex (calprotectin) in male Japanese with abdominal adiposity and dysregulated expression of S100A8 and S100A9 in adipose tissues of obese mice

(2012) Ryohei Sekimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multiple Roles for Neutrophils in Atherosclerosis

(2012) Oliver Soehnlein   CIRCULATION RESEARCH

High serum S100A8/A9 levels and high cardiovascular complication rate in type 2 diabetics with ultrasonographic low carotid plaque density

(2012) Ayumu Hirata et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Serum and urinary concentrations of calprotectin as markers of insulin resistance and type 2 diabetes

(2012) Francisco J Ortega et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

S100A8 and S100A9—oxidant scavengers in inflammation

(2012) Lincoln H. Gomes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Induction of nuclear factor-κB responses by the S100A9 protein is Toll-like receptor-4-dependent

(2012) Matteo Riva et al.   IMMUNOLOGY

Alarmins: awaiting a clinical response

(2012) James K. Chan et al.   JOURNAL OF CLINICAL INVESTIGATION

Diagnostic evaluation of the MRP-8/14 for the emergency assessment of chest pain

(2012) Amit N. Vora et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

S100A9 Interaction with TLR4 Promotes Tumor Growth

(2012) Eva Källberg et al.   PLoS One

High Levels of S100A12 Are Associated With Recent Plaque Symptomatology in Patients With Carotid Atherosclerosis

(2012) Azhar Abbas et al.   STROKE

S100A8 and S100A9 in Cardiovascular Biology and Disease

(2011) Michelle M. Averill et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pharmacokinetics, tolerability, and preliminary efficacy of paquinimod (ABR-215757), a new quinoline-3-carboxamide derivative: Studies in lupus-prone mice and a multicenter, randomized, double-blind, placebo-controlled, repeat-dose, dose-ranging study in

(2011) Anders A. Bengtsson et al.   ARTHRITIS AND RHEUMATISM

Myeloid related proteins activate Toll-like receptor 4 in human acute coronary syndromes

(2011) Keiko Yonekawa et al.   ATHEROSCLEROSIS

Increased serum myeloid-related protein 8/14 level is associated with atherosclerosis in type 2 diabetic patients

(2011) Wen Peng et al.   Cardiovascular Diabetology

S100A9 Differentially Modifies Phenotypic States of Neutrophils, Macrophages, and Dendritic Cells

(2011) Michelle M. Averill et al.   CIRCULATION

RAGE-Dependent Regulation of Calcium-Binding Proteins S100A8 and S100A9 in Human THP-1

(2011) K. Eggers et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

The Elevated Serum S100A8/A9 During Acute Myocardial Infarction Is Not of Cardiac Myocyte Origin

(2011) Chang-Qing Du et al.   INFLAMMATION

S100A8/A9 complex as a new biomarker in prediction of mortality in elderly patients with severe heart failure

(2011) Li-Ping Ma et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Phase II Randomized, Double-Blind, Placebo-Controlled Study of Tasquinimod in Men With Minimally Symptomatic Metastatic Castrate-Resistant Prostate Cancer

(2011) Roberto Pili et al.   JOURNAL OF CLINICAL ONCOLOGY

The down regulation of neutrophil oxidative metabolism by S100A8 and S100A9: Implication of the protease-activated receptor-2

(2011) Herve Y. Sroussi et al.   MOLECULAR IMMUNOLOGY

The immune system in atherosclerosis

(2011) Göran K Hansson et al.   NATURE IMMUNOLOGY

Atherosclerosis: current pathogenesis and therapeutic options

(2011) Christian Weber et al.   NATURE MEDICINE

Inflammation-associated S100 proteins: new mechanisms that regulate function

(2010) Jesse Goyette et al.   AMINO ACIDS

Oxidative Modifications of DAMPs Suppress Inflammation: The Case for S100A8 and S100A9

(2010) Su Yin Lim et al.   ANTIOXIDANTS & REDOX SIGNALING

Hyperlipidemia-Triggered Neutrophilia Promotes Early Atherosclerosis

(2010) Maik Drechsler et al.   CIRCULATION

Enhanced Expression of the S100A8/A9 Complex in Acute Myocardial Infarction Patients

(2010) Takashi Katashima et al.   CIRCULATION JOURNAL

S100A8 and S100A9 inhibit neutrophil oxidative metabolismin-vitro: Involvement of adenosine metabolites

(2010) Herve Y. Sroussi et al.   FREE RADICAL RESEARCH

The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells

(2010) Karin Loser et al.   NATURE MEDICINE

High Myeloid-Related Protein

(2010) Mihaela G. Ionita et al.   STROKE

High Levels of Myeloid-Related Protein 14 in Human Atherosclerotic Plaques Correlate With the Characteristics of Rupture-Prone Lesions

(2009) Mihaela G. Ionita et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Comparison of gene expression profiles between human and mouse monocyte subsets

(2009) M. A. Ingersoll et al.   BLOOD

Myeloid-Related Protein-8/14 Is Critical for the Biological Response to Vascular Injury

(2009) Kevin Croce et al.   CIRCULATION

Hyperglycemia-Induced Reactive Oxygen Species Increase Expression of the Receptor for Advanced Glycation End Products (RAGE) and RAGE Ligands

(2009) D. Yao et al.   DIABETES

Macrophage suppression following phagocytosis of apoptotic neutrophils is mediated by the S100A9 calcium-binding protein

(2009) B.H.P. De Lorenzo et al.   IMMUNOBIOLOGY

Deficiency in TLR4 signal transduction ameliorates cardiac injury and cardiomyocyte contractile dysfunction during ischemia

(2009) Peng Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pleiotropic Roles of S100A12 in Coronary Atherosclerotic Plaque Formation and Rupture

(2009) J. Goyette et al.   JOURNAL OF IMMUNOLOGY

The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer

(2009) Jan M. Ehrchen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Calprotectin — A Novel Marker of Obesity

(2009) Ole Hartvig Mortensen et al.   PLoS One

Identification of Human S100A9 as a Novel Target for Treatment of Autoimmune Disease via Binding to Quinoline-3-Carboxamides

(2009) Per Björk et al.   PLOS BIOLOGY

RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis

(2008) Olga Turovskaya et al.   CARCINOGENESIS

S100A8 and S100A9 Mediate Endotoxin-Induced Cardiomyocyte Dysfunction via the Receptor for Advanced Glycation End Products

(2008) John H. Boyd et al.   CIRCULATION RESEARCH

Receptor for Advanced Glycation End Products (RAGE) Deficiency Attenuates the Development of Atherosclerosis in Diabetes

(2008) A. Soro-Paavonen et al.   DIABETES

Substitution of methionine 63 or 83 in S100A9 and cysteine 42 in S100A8 abrogate the antifungal activities of S100A8/A9: potential role for oxidative regulation

(2008) Herve Y. Sroussi et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

The calcium binding protein S100A9 is essential for pancreatic leukocyte infiltration and induces disruption of cell–cell contacts

(2008) Jürgen Schnekenburger et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE–/– mice

(2008) Evis Harja et al.   JOURNAL OF CLINICAL INVESTIGATION

RAGE signaling sustains inflammation and promotes tumor development

(2008) Christoffer Gebhardt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway

(2008) S. Ghavami et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Evaluation and Infection Theraphy: Thrombolysis in Myocardial Infarction (PROVE IT-TIMI 22) trial

(2007) David A. Morrow et al.   AMERICAN HEART JOURNAL

Protective Role of CXC Receptor 4/CXC Ligand 12 Unveils the Importance of Neutrophils in Atherosclerosis

(2007) Alma Zernecke et al.   CIRCULATION RESEARCH