The PCNA interaction motifs revisited: thinking outside the PIP-box

Rational Design of a 310 -Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp

(2018) Kate L. Wegener et al.   CHEMISTRY-A EUROPEAN JOURNAL

IUPred2A: context-dependent prediction of protein disorder as a function of redox state and protein binding

(2018) Bálint Mészáros et al.   NUCLEIC ACIDS RESEARCH

Short linear motif core and flanking regions modulate retinoblastoma protein binding affinity and specificity

(2018) Nicolás Palopoli et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Structure of proliferating cell nuclear antigen (PCNA) bound to an APIM peptide reveals the universality of PCNA interaction

(2018) Kodai Hara et al.   Acta Crystallographica Section F-Structural Biology Communications

Maneuvers on PCNA Rings during DNA Replication and Repair

(2018) Dea Slade   Genes

SLiMSearch: a framework for proteome-wide discovery and annotation of functional modules in intrinsically disordered regions

(2017) Izabella Krystkowiak et al.   NUCLEIC ACIDS RESEARCH

Improvements to the APBS biomolecular solvation software suite

(2017) Elizabeth Jurrus et al.   PROTEIN SCIENCE

Structural insights into the function of ZRANB3 in replication stress response

(2017) Marek Sebesta et al.   Nature Communications

Crystal structure of human PCNA in complex with the PIP box of DVC1

(2016) Yong Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

R.I.P. to the PIP: PCNA-binding motif no longer considered specific

(2016) Elizabeth M. Boehm et al.   BIOESSAYS

Structures and Short Linear Motif of Disordered Transcription Factor Regions Provide Clues to the Interactome of the Cellular Hub Protein Radical-induced Cell Death1

(2016) Charlotte O'Shea et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site

(2016) Caroline M. Duffy et al.   JOURNAL OF MOLECULAR BIOLOGY

Evolution of domain–peptide interactions to coadapt specificity and affinity to functional diversity

(2016) Abdellali Kelil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Experimental detection of short regulatory motifs in eukaryotic proteins: tips for good practice as well as for bad

(2015) Toby J. Gibson et al.   Cell Communication and Signaling

Short linear motifs – ex nihilo evolution of protein regulation

(2015) Norman E. Davey et al.   Cell Communication and Signaling

PCNA-interacting peptides reduce Akt phosphorylation and TLR-mediated cytokine secretion suggesting a role of PCNA in cellular signaling

(2015) Camilla Olaisen et al.   CELLULAR SIGNALLING

The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants

(2015) Dragony Fu et al.   DNA REPAIR

TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress

(2015) Saskia Hoffmann et al.   JOURNAL OF CELL BIOLOGY

Structure of p15PAF–PCNA complex and implications for clamp sliding during DNA replication and repair

(2015) Alfredo De Biasio et al.   Nature Communications

DISOPRED3: precise disordered region predictions with annotated protein-binding activity

(2014) David T. Jones et al.   BIOINFORMATICS

p15PAF Is an Intrinsically Disordered Protein with Nonrandom Structural Preferences at Sites of Interaction with Other Proteins

(2014) Alfredo De Biasio et al.   BIOPHYSICAL JOURNAL

Short Linear Motifs: Ubiquitous and Functionally Diverse Protein Interaction Modules Directing Cell Regulation

(2014) Kim Van Roey et al.   CHEMICAL REVIEWS

Spd2 assists Spd1 in the modulation of ribonucleotide reductase architecture but does not regulate deoxynucleotide pools

(2014) R. Vejrup-Hansen et al.   JOURNAL OF CELL SCIENCE

A Million Peptide Motifs for the Molecular Biologist

(2014) Peter Tompa et al.   MOLECULAR CELL

PIP degron proteins, substrates of CRL4Cdt2, and not PIP boxes, interfere with DNA polymerase η and κ focus formation on UV damage

(2014) Nikolay Tsanov et al.   NUCLEIC ACIDS RESEARCH

Promiscuity as a functional trait: intrinsically disordered regions as central players of interactomes

(2013) Alexander Cumberworth et al.   BIOCHEMICAL JOURNAL

PCNA trimer instability inhibits translesion synthesis by DNA polymerase η and by DNA polymerase δ

(2013) Lynne M. Dieckman et al.   DNA REPAIR

Spd1 accumulation causes genome instability independently of ribonucleotide reductase activity but functions to protect the genome when deoxynucleotide pools are elevated

(2013) O. Fleck et al.   JOURNAL OF CELL SCIENCE

Binding of disordered proteins to a protein hub

(2013) Elio A. Cino et al.   Scientific Reports

Ribonucleotide Reductase Activity Is Coupled to DNA Synthesis via Proliferating Cell Nuclear Antigen

(2012) Israel Salguero et al.   CURRENT BIOLOGY

Elucidation of the binding preferences of peptide recognition modules: SH3 and PDZ domains

(2012) Joan Teyra et al.   FEBS LETTERS

Distinct Peptide Binding Specificities of Src Homology 3 (SH3) Protein Domains Can Be Determined by Modulation of Local Energetics across the Binding Interface

(2012) Maryna Gorelik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Role for Proliferating Cell Nuclear Antigen in Substrate Recognition by the E3 Ubiquitin Ligase CRL4Cdt2

(2012) Courtney G. Havens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spartan/C1orf124, a Reader of PCNA Ubiquitylation and a Regulator of UV-Induced DNA Damage Response

(2012) Richard C. Centore et al.   MOLECULAR CELL

Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2

(2012) Anthony A. Armstrong et al.   NATURE

Proliferating Cell Nuclear Antigen (PCNA) Interactions in Solution Studied by NMR

(2012) Alfredo De Biasio et al.   PLoS One

Accelerated NMR Spectroscopy by Using Compressed Sensing

(2011) Krzysztof Kazimierczuk et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sequence correction of random coil chemical shifts: correlation between neighbor correction factors and changes in the Ramachandran distribution

(2011) Magnus Kjaergaard et al.   JOURNAL OF BIOMOLECULAR NMR

Random coil chemical shift for intrinsically disordered proteins: effects of temperature and pH

(2011) Magnus Kjaergaard et al.   JOURNAL OF BIOMOLECULAR NMR

PCNA directs type 2 RNase H activity on DNA replication and repair substrates

(2011) Doryen Bubeck et al.   NUCLEIC ACIDS RESEARCH

Regulation of ribonucleotide reductase by Spd1 involves multiple mechanisms

(2010) K. Nestoras et al.   GENES & DEVELOPMENT

Positively charged residues located downstream of PIP box, together with TD amino acids within PIP box, are important for CRL4Cdt2-mediated proteolysis

(2010) Masato Michishita et al.   GENES TO CELLS

PCNA on the crossroad of cancer

(2009) Ivaylo Stoimenov et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen

(2009) Asami Hishiki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a novel, widespread, and functionally important PCNA-binding motif

(2009) Karin M. Gilljam et al.   JOURNAL OF CELL BIOLOGY

Docking of a Specialized PIP Box onto Chromatin-Bound PCNA Creates a Degron for the Ubiquitin Ligase CRL4Cdt2

(2009) Courtney G. Havens et al.   MOLECULAR CELL

Residual structure within the disordered C-terminal segment of p21Waf1/Cip1/Sdi1and its implications for molecular recognition

(2009) Mi-Kyung Yoon et al.   PROTEIN SCIENCE

Crystal structures of theArabidopsis thalianaproliferating cell nuclear antigen 1 and 2 proteins complexed with the human p21 C-terminal segment

(2009) Wojciech Strzalka et al.   PROTEIN SCIENCE

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex

(2008) T. Abbas et al.   GENES & DEVELOPMENT

Structural insight into recruitment of translesion DNA polymerase Dpo4 to sliding clamp PCNA

(2008) Guangxin Xing et al.   MOLECULAR MICROBIOLOGY