PIP degron proteins, substrates of CRL4Cdt2, and not PIP boxes, interfere with DNA polymerase η and κ focus formation on UV damage

Degradation of p12 Subunit by CRL4Cdt2E3 Ligase Inhibits Fork Progression after DNA Damage

(2013) Kenta Terai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress

(2013) Yeon-Tae Jeong et al.   JOURNAL OF CELL BIOLOGY

UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability

(2013) S. F. Mansilla et al.   NUCLEIC ACIDS RESEARCH

The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells

(2013) Agathe Bacquin et al.   NUCLEIC ACIDS RESEARCH

FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress

(2013) Kasper Fugger et al.   Nature Communications

Two Different Replication Factor C Proteins, Ctf18 and RFC1, Separately Control PCNA-CRL4Cdt2-Mediated Cdt1 Proteolysis during S Phase and following UV Irradiation

(2012) Y. Shiomi et al.   MOLECULAR AND CELLULAR BIOLOGY

Y-family DNA polymerases and their role in tolerance of cellular DNA damage

(2012) Julian E. Sale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cdt1 Is Differentially Targeted for Degradation by Anticancer Chemotherapeutic Drugs

(2012) Athanasia Stathopoulou et al.   PLoS One

Mechanism of CRL4Cdt2, a PCNA-dependent E3 ubiquitin ligase

(2011) C. G. Havens et al.   GENES & DEVELOPMENT

The hMsh2-hMsh6 Complex Acts in Concert with Monoubiquitinated PCNA and Pol η in Response to Oxidative DNA Damage in Human Cells

(2011) Anastasia Zlatanou et al.   MOLECULAR CELL

A Genome-wide Screen Identifies p97 as an Essential Regulator of DNA Damage-Dependent CDT1 Destruction

(2011) Malavika Raman et al.   MOLECULAR CELL

DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity

(2011) Noam Diamant et al.   NUCLEIC ACIDS RESEARCH

Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation

(2011) Estrella Guarino et al.   NUCLEIC ACIDS RESEARCH

The RAD6 DNA Damage Tolerance Pathway Operates Uncoupled from the Replication Fork and Is Functional Beyond S Phase

(2010) Georgios I. Karras et al.   CELL

DNA damage induced Pol η recruitment takes place independently of the cell cycle phase

(2010) Gaston Soria et al.   CELL CYCLE

PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?

(2010) Gastón Soria et al.   DNA REPAIR

Positively charged residues located downstream of PIP box, together with TD amino acids within PIP box, are important for CRL4Cdt2-mediated proteolysis

(2010) Masato Michishita et al.   GENES TO CELLS

ATR/Chk1 pathway is essential for resumption of DNA synthesis and cell survival in UV-irradiated XP variant cells

(2010) Emmanuelle Despras et al.   HUMAN MOLECULAR GENETICS

Regulation of Translesion Synthesis DNA Polymerase η by Monoubiquitination

(2010) Marzena Bienko et al.   MOLECULAR CELL

Three DNA Polymerases, Recruited by Different Mechanisms, Carry Out NER Repair Synthesis in Human Cells

(2010) Tomoo Ogi et al.   MOLECULAR CELL

CRL4Cdt2 E3 Ubiquitin Ligase Monoubiquitinates PCNA to Promote Translesion DNA Synthesis

(2010) Kenta Terai et al.   MOLECULAR CELL

Regulation of the Histone H4 Monomethylase PR-Set7 by CRL4Cdt2-Mediated PCNA-Dependent Degradation during DNA Damage

(2010) Hisanobu Oda et al.   MOLECULAR CELL

CRL4Cdt2-Mediated Destruction of the Histone Methyltransferase Set8 Prevents Premature Chromatin Compaction in S Phase

(2010) Richard C. Centore et al.   MOLECULAR CELL

CRL4Cdt2 Regulates Cell Proliferation and Histone Gene Expression by Targeting PR-Set7/Set8 for Degradation

(2010) Tarek Abbas et al.   MOLECULAR CELL

Structure and mechanism of human DNA polymerase η

(2010) Christian Biertümpfel et al.   NATURE

Ubiquitin-dependent DNA damage bypass is separable from genome replication

(2010) Yasukazu Daigaku et al.   NATURE

The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells

(2010) Mathieu Tardat et al.   NATURE CELL BIOLOGY

Analysis of the role of PCNA-DNA contacts during clamp loading

(2010) Randall McNally et al.   BMC STRUCTURAL BIOLOGY

Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen

(2009) Asami Hishiki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Docking of a Specialized PIP Box onto Chromatin-Bound PCNA Creates a Degron for the Ubiquitin Ligase CRL4Cdt2

(2009) Courtney G. Havens et al.   MOLECULAR CELL

Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APCCdh1 in G1 phase

(2008) Geneviève Rodier et al.   EMBO JOURNAL

DNA-damage response control of E2F7 and E2F8

(2008) L Panagiotis Zalmas et al.   EMBO REPORTS

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex

(2008) T. Abbas et al.   GENES & DEVELOPMENT

The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing

(2008) Y. Kim et al.   GENES & DEVELOPMENT

CDK Inhibitor p21 Is Degraded by a Proliferating Cell Nuclear Antigen-coupled Cul4-DDB1Cdt2Pathway during S Phase and after UV Irradiation

(2008) Hideo Nishitani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation

(2008) G. Soria et al.   JOURNAL OF CELL SCIENCE

Regulated Proteolysis of DNA Polymerase η during the DNA-Damage Response in C. elegans

(2008) Seung-Hwan Kim et al.   MOLECULAR CELL

SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation

(2008) Thomas F. Westbrook et al.   NATURE