Hepatitis B virus X protein enhances the development of liver fibrosis and the expression of genes associated with epithelial-mesenchymal transitions and tumor progenitor cells

Polyploidy spectrum: a new marker in HCC classification

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Comprehensive and Integrative Analysis Reveals the Diagnostic, Clinicopathological and Prognostic Significance of Polo-Like Kinase 1 in Hepatocellular Carcinoma

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Hepatocellular carcinoma-related cyclin D1 is selectively regulated by autophagy degradation system

(2018) Shan-Ying Wu et al.   HEPATOLOGY

Essential Role of Polo-like Kinase 1 (Plk1) Oncogene in Tumor Growth and Metastasis of Tamoxifen-Resistant Breast Cancer

(2018) Sung Baek Jeong et al.   MOLECULAR CANCER THERAPEUTICS

Hepatitis B virus infection

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Overexpression of Rac GTPase Activating Protein 1 Contributes to Proliferation of Cancer Cells by Reducing Hippo Signaling to Promote Cytokinesis

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Targeting LC3 and Beclin-1 autophagy genes suppresses proliferation, survival, migration and invasion by inhibition of Cyclin-D1 and uPAR/Integrin β1/ Src signaling in triple negative breast cancer cells

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Reactive Oxygen Species-Mediated c-Jun NH 2 -Terminal Kinase Activation Contributes to Hepatitis B Virus X Protein-Induced Autophagy via Regulation of the Beclin-1/Bcl-2 Interaction

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Hepatitis B virus X protein promotes the development of liver fibrosis and hepatoma through downregulation of miR-30e targeting P4HA2 mRNA

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Ursolic Acid Suppresses Hepatitis B Virus X Protein-mediated Autophagy and Chemotherapeutic Drug Resistance

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p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells

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Ammonia produces pathological changes in human hepatic stellate cells and is a target for therapy of portal hypertension

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Mechanisms of HBV-induced hepatocellular carcinoma

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Proteomic profiling of HBV infected liver biopsies with different fibrotic stages

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Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP

(2016) Duyen Amy Bui et al.   Science Signaling

Hepatitis B virus dampens autophagy maturation via negative regulation of Rab7 expression

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Hepatitis B virus X protein mediates yes-associated protein 1 upregulation in hepatocellular carcinoma

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Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling

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Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP

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Hepatic SATB1 induces paracrine activation of hepatic stellate cells and is upregulated by HBx

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Differential reactivation of fetal/neonatal genes in mouse liver tumors induced in cirrhotic and non-cirrhotic conditions

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Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease

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Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation

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Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation

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The expression of beclin-1, an autophagic gene, in hepatocellular carcinoma associated with clinical pathological and prognostic significance

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Hepatitis B virus X protein activates human hepatic stellate cells through upregulating TGFβ1

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C-terminal-truncated hepatitis B virus X protein enhances the development of diethylnitrosamine-induced hepatocellular carcinogenesis

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Autophagic LC3B overexpression correlates with malignant progression and predicts a poor prognosis in hepatocellular carcinoma

(2014) Dong-Hao Wu et al.   TUMOR BIOLOGY

Polyploidization in Liver Tissue

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Role of p62/SQSTM1 in liver physiology and pathogenesis

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Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment

(2013) Juanjuan Zhao et al.   HEPATOLOGY

Hepatitis B virus HBx protein impairs liver regeneration through enhanced expression of IL-6 in transgenic mice

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Zonation of Nitrogen and Glucose Metabolism Gene Expression upon Acute Liver Damage in Mouse

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Autophagy-deficient mice develop multiple liver tumors

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Hepatitis B virus x protein in the pathogenesis of hepatitis B virus-induced hepatocellular carcinoma

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Subversion of Cellular Autophagy Machinery by Hepatitis B Virus for Viral Envelopment

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Accelerated liver fibrosis in hepatitis B virus transgenic mice: Involvement of natural killer T cells

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Regulation of Beclin 1 in autophagy

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Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease

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Over-expression of glutamine synthetase in focal nodular hyperplasia: a novel easy diagnostic tool in surgical pathology

(2009) Paulette Bioulac-Sage et al.   LIVER INTERNATIONAL

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Hepatitis B virus X protein sensitizes cells to starvation-induced autophagy via up-regulation of beclin 1 expression

(2008) Hong Tang et al.   HEPATOLOGY

The hepatitis B virus X protein induces paracrine activation of human hepatic stellate cells

(2008) Samuel Martín-Vílchez et al.   HEPATOLOGY

Analyzing real-time PCR data by the comparative CT method

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