Targeting LC3 and Beclin-1 autophagy genes suppresses proliferation, survival, migration and invasion by inhibition of Cyclin-D1 and uPAR/Integrin β1/ Src signaling in triple negative breast cancer cells

The exponential growth of autophagy-related research: from the humble yeast to the Nobel Prize

(2017) Noboru Mizushima   FEBS LETTERS

DNA damage repair in breast cancer and its therapeutic implications

(2017) Reem Ali et al.   PATHOLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Role of the mammalian ATG8/LC3 family in autophagy: differential and compensatory roles in the spatiotemporal regulation of autophagy

(2016) You-Kyung Lee et al.   BMB Reports

Clinical significance of the expression of autophagy-associated marker, beclin 1, in breast cancer patients who received neoadjuvant endocrine therapy

(2016) Takayuki Ueno et al.   BMC CANCER

Decreased expression of autophagy protein LC3 and stemness (CD44+/CD24−/low) indicate poor prognosis in triple-negative breast cancer

(2016) Shu-Jyuan Chang et al.   HUMAN PATHOLOGY

H2O2 treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin fibroblasts by inhibiting the PI3K/Akt signaling pathway

(2016) Shanmin Zhao et al.   Oncotarget

A highly invasive subpopulation of MDA-MB-231 breast cancer cells shows accelerated growth, differential chemoresistance, features of apocrine tumors and reduced tumorigenicity in vivo

(2016) Adriana Amaro et al.   Oncotarget

FOXM1 regulates expression of eukaryotic elongation factor 2 kinase and promotes proliferation, invasion and tumorgenesis of human triple negative breast cancer cells

(2016) Zuhal Hamurcu et al.   Oncotarget

Crystal structure-based discovery of a novel synthesized PARP1 inhibitor (OL-1) with apoptosis-inducing mechanisms in triple-negative breast cancer

(2016) Leilei Fu et al.   Scientific Reports

Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3

(2016) Marina N. Sharifi et al.   Cell Reports

Autophagy regulation in the development and treatment of breast cancer

(2015) Yuting Zhou et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Divergent roles of BECN1 in LC3 lipidation and autophagosomal function

(2015) Ruina He et al.   Autophagy

DNA damage response markers are differentially expressed in BRCA-mutated breast cancers

(2015) Mohammed Aleskandarany et al.   BREAST CANCER RESEARCH AND TREATMENT

Up-Regulation of Glioma-Associated Oncogene Homolog 1 Expression by Serum Starvation Promotes Cell Survival in ER-Positive Breast Cancer Cells

(2015) Juan Xu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Antcin K, an Active Triterpenoid from the Fruiting Bodies of Basswood-Cultivated Antrodia cinnamomea, Inhibits Metastasis via Suppression of Integrin-Mediated Adhesion, Migration, and Invasion in Human Hepatoma Cells

(2015) Ya-Ling Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

TRIP-Br1 oncoprotein inhibits autophagy, apoptosis, and necroptosis under nutrient/serum-deprived condition

(2015) Samil Jung et al.   Oncotarget

Targeting autophagy in cancer management – strategies and developments

(2015) Bulent Ozpolat et al.   Cancer Management and Research

Decreased BECN1 mRNA Expression in Human Breast Cancer is Associated With Estrogen Receptor-Negative Subtypes and Poor Prognosis

(2015) Hao Tang et al.   EBioMedicine

Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity

(2014) Michelle Cicchini et al.   Autophagy

Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers

(2014) Sylvain Lefort et al.   Autophagy

The pro-apoptotic role of autophagy in breast cancer

(2014) S Suman et al.   BRITISH JOURNAL OF CANCER

Gene of the month:BECN1

(2014) Sumit Sahni et al.   JOURNAL OF CLINICAL PATHOLOGY

LC3B-II deacetylation by histone deacetylase 6 is involved in serum-starvation-induced autophagic degradation

(2013) Kun-Peng Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lower mRNA and Protein Expression Levels of LC3 and Beclin1, Markers of Autophagy, were Correlated with Progression of Renal Clear Cell Carcinoma

(2013) Q. Deng et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

A diterpenoid compound, excisanin A, inhibits the invasive behavior of breast cancer cells by modulating the integrin β1/FAK/PI3K/AKT/β-catenin signaling

(2013) Juan Qin et al.   LIFE SCIENCES

Low expression of Beclin 1 and elevated expression of HIF-1α refine distant metastasis risk and predict poor prognosis of ER-positive, HER2-negative breast cancer

(2013) Min Dong et al.   MEDICAL ONCOLOGY

High expression of LC3B is associated with progression and poor outcome in triple-negative breast cancer

(2013) Hong Zhao et al.   MEDICAL ONCOLOGY

Expression of autophagy-related markers beclin-1, light chain 3A, light chain 3B and p62 according to the molecular subtype of breast cancer

(2012) Junjeong Choi et al.   HISTOPATHOLOGY

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Targeted Silencing of Elongation Factor 2 Kinase Suppresses Growth and Sensitizes Tumors to Doxorubicin in an Orthotopic Model of Breast Cancer

(2012) Ibrahim Tekedereli et al.   PLoS One

Autophagy inhibition enhances ursolic acid-induced apoptosis in PC3 cells

(2011) Seoung Woo Shin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PARP-1 expression in breast cancer including BRCA1-associated, triple negative and basal-like tumors: possible implications for PARP-1 inhibitor therapy

(2011) Pawel Domagala et al.   BREAST CANCER RESEARCH AND TREATMENT

The Paradox of Triple Negative Breast Cancer: Novel Approaches to Treatment

(2011) Monica Fornier et al.   Breast Journal

Enhanced Integrin Mediated Signaling and Cell Cycle Progression on Fibronectin Mimetic Peptide Amphiphile Monolayers

(2011) Kamlesh Shroff et al.   LANGMUIR

Multi-step process of human breast carcinogenesis: A role for BRCA1, BECN1, CCND1, PTEN and UVRAG

(2011) Jun-Qing Wang   Molecular Medicine Reports

Combination of N-(4-hydroxyphenyl) retinamide and apigenin suppressed starvation-induced autophagy and promoted apoptosis in malignant neuroblastoma cells

(2011) Nishant Mohan et al.   NEUROSCIENCE LETTERS

Targeting the pro-death and pro-survival functions of autophagy as novel therapeutic strategies in cancer

(2010) Kevin Dalby et al.   Autophagy

Genetic and epigenetic silencing of the beclin 1gene in sporadic breast tumors

(2010) Zidong Li et al.   BMC CANCER

Triple-Negative Breast Cancer

(2010) William D. Foulkes et al.   NEW ENGLAND JOURNAL OF MEDICINE

uPAR promotes formation of the p130Cas–Crk complex to activate Rac through DOCK180

(2008) Harvey W. Smith et al.   JOURNAL OF CELL BIOLOGY