Hsp70 molecular chaperones: multifunctional allosteric holding and unfolding machines

Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity

(2018) Franziska Kundel et al.   ACS Chemical Biology

Chaperoning the guardian of the genome. The two-faced role of molecular chaperones in p53 tumor suppressor action

(2018) Bartosz Wawrzynow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Roles of the nucleotide exchange factor and chaperone Hsp110 in cellular proteostasis and diseases of protein misfolding

(2018) Unekwu M. Yakubu et al.   BIOLOGICAL CHEMISTRY

Hsp70 at the membrane: driving protein translocation

(2018) Elizabeth A. Craig   BMC BIOLOGY

Protein Folding Mediated by Trigger Factor and Hsp70: New Insights from Single-Molecule Approaches

(2018) Florian Wruck et al.   JOURNAL OF MOLECULAR BIOLOGY

Cellular Handling of Protein Aggregates by Disaggregation Machines

(2018) Axel Mogk et al.   MOLECULAR CELL

Molecular Mechanism of J-Domain-Triggered ATP Hydrolysis by Hsp70 Chaperones

(2018) Roman Kityk et al.   MOLECULAR CELL

Hsp90 Breaks the Deadlock of the Hsp70 Chaperone System

(2018) Tania Morán Luengo et al.   MOLECULAR CELL

Bap (Sil1) regulates the molecular chaperone BiP by coupling release of nucleotide and substrate

(2018) Mathias Rosam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nucleotide exchange factors Fes1 and HspBP1 mimic substrate to release misfolded proteins from Hsp70

(2018) Naveen K. C. Gowda et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hsp70–Bag3 complex is a hub for proteotoxicity-induced signaling that controls protein aggregation

(2018) Anatoli B. Meriin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Disaggregation in Multicellular Organisms

(2018) Nadinath B. Nillegoda et al.   TRENDS IN BIOCHEMICAL SCIENCES

Bap (Sil1) regulates the molecular chaperone BiP by coupling release of nucleotide and substrate

(2018) Mathias Rosam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nucleotide exchange factors Fes1 and HspBP1 mimic substrate to release misfolded proteins from Hsp70

(2018) Naveen K. C. Gowda et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inhibitors and chemical probes for molecular chaperone networks

(2018) Jason E. Gestwicki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The C-terminal GGAP motif of Hsp70 mediates substrate recognition and stress response in yeast

(2018) Weibin Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric Modulators of HSP90 and HSP70: Dynamics Meets Function through Structure-Based Drug Design

(2018) Mariarosaria Ferraro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release

(2018) Manjeet Mukherjee et al.   Science Signaling

Function, evolution, and structure of J-domain proteins

(2018) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

The endoplasmic reticulum (ER) chaperone BiP is a master regulator of ER functions: Getting by with a little help from ERdj friends

(2018) Kristine Faye R. Pobre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent advances in the structural and mechanistic aspects of Hsp70 molecular chaperones

(2018) Matthias P Mayer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the post-translational protein translocation machinery of the ER membrane

(2018) Xudong Wu et al.   NATURE

Allosteric landscapes of eukaryotic cytoplasmic Hsp70s are shaped by evolutionary tuning of key interfaces

(2018) Wenli Meng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hsp70 - a master regulator in protein degradation

(2017) María Rosario Fernández-Fernández et al.   FEBS LETTERS

Regulation of mitochondrial protein import by the nucleotide exchange factors GrpEL1 and GrpEL2 in human cells

(2017) Shubhi Srivastava et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Key features of an Hsp70 chaperone allosteric landscape revealed by ion-mobility native mass spectrometry and double electron-electron resonance

(2017) Alex L. Lai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Hsp70 interdomain linker is a dynamic switch that enables allosteric communication between two structured domains

(2017) Charles A. English et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins

(2017) Jennifer N. Rauch et al.   JOURNAL OF MOLECULAR BIOLOGY

Coordinated Hsp110 and Hsp104 Activities Power Protein Disaggregation in Saccharomyces cerevisiae

(2017) Jayasankar Mohanakrishnan Kaimal et al.   MOLECULAR AND CELLULAR BIOLOGY

Substrate binding by the yeast Hsp110 nucleotide exchange factor and molecular chaperone Sse1 is not obligate for its biological activities

(2017) Veronica M. Garcia et al.   MOLECULAR BIOLOGY OF THE CELL

Two chaperones locked in an embrace: structure and function of the ribosome-associated complex RAC

(2017) Ying Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNAJ Proteins in neurodegeneration: essential and protective factors

(2017) Christina Zarouchlioti et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Conformational heterogeneity in the Hsp70 chaperone-substrate ensemble identified from analysis of NMR-detected titration data

(2017) Ashok Sekhar et al.   PROTEIN SCIENCE

How Do J-Proteins Get Hsp70 to Do So Many Different Things?

(2017) Elizabeth A. Craig et al.   TRENDS IN BIOCHEMICAL SCIENCES

Two chaperones locked in an embrace: structure and function of the ribosome-associated complex RAC

(2017) Ying Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Promiscuous binding by Hsp70 results in conformational heterogeneity and fuzzy chaperone-substrate ensembles

(2017) Rina Rosenzweig et al.   eLife

Allosteric fine-tuning of the conformational equilibrium poises the chaperone BiP for post-translational regulation

(2017) Lukasz Wieteska et al.   eLife

AMPylation targets the rate-limiting step of BiP’s ATPase cycle for its functional inactivation

(2017) Steffen Preissler et al.   eLife

Modeling Hsp70/Hsp40 interaction by multi-scale molecular simulations and coevolutionary sequence analysis

(2017) Duccio Malinverni et al.   eLife

The Role of the Multifunctional BAG3 Protein in Cellular Protein Quality Control and in Disease

(2017) Elisabeth Stürner et al.   Frontiers in Molecular Neuroscience

The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases

(2017) Rachel E. Lackie et al.   Frontiers in Neuroscience

Protein Quality Control by Molecular Chaperones in Neurodegeneration

(2017) Aaron Ciechanover et al.   Frontiers in Neuroscience

Experimental Milestones in the Discovery of Molecular Chaperones as Polypeptide Unfolding Enzymes

(2016) Andrija Finka et al.   Annual Review of Biochemistry

Targeting Hsp70: A possible therapy for cancer

(2016) Sanjay Kumar et al.   CANCER LETTERS

Neurodegeneration and the Heat Shock Protein 70 Machinery: Implications for Therapeutic Development

(2016) Sarah N. Fontaine et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Targeting Allosteric Control Mechanisms in Heat Shock Protein 70 (Hsp70)

(2016) Xiaokai Li et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Monitoring conformational heterogeneity of the lid of DnaK substrate-binding domain during its chaperone cycle

(2016) Rupa Banerjee et al.   FEBS Journal

Identification of a LargeDNAJB2Deletion in a Family with Spinal Muscular Atrophy and Parkinsonism

(2016) Elena Sanchez et al.   HUMAN MUTATION

Non-canonical Interactions between Heat Shock Cognate Protein 70 (Hsc70) and Bcl2-associated Anthanogene (BAG) Co-Chaperones Are Important for Client Release

(2016) Jennifer N. Rauch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bag1 Co-chaperone Promotes TRC8 E3 Ligase-dependent Degradation of Misfolded Human Ether a Go-Go-related Gene (hERG) Potassium Channels

(2016) Christine Hantouche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Members of the Hsp70 Family Recognize Distinct Types of Sequences to Execute ER Quality Control

(2016) Julia Behnke et al.   MOLECULAR CELL

The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model

(2016) Vaishali Kakkar et al.   MOLECULAR CELL

Modulation of Molecular Chaperones in Huntington’s Disease and Other Polyglutamine Disorders

(2016) Sara D. Reis et al.   MOLECULAR NEUROBIOLOGY

Alternative modes of client binding enable functional plasticity of Hsp70

(2016) Alireza Mashaghi et al.   NATURE

Clathrin-coat disassembly illuminates the mechanisms of Hsp70 force generation

(2016) Rui Sousa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hsp70 biases the folding pathways of client proteins

(2016) Ashok Sekhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

Dynamical Structures of Hsp70 and Hsp70-Hsp40 Complexes

(2016) Thomas Reid Alderson et al.   STRUCTURE

Breaking BAG: The Co-Chaperone BAG3 in Health and Disease

(2016) Christian Behl   TRENDS IN PHARMACOLOGICAL SCIENCES

Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction

(2016) Marie A. Hanebuth et al.   Nature Communications

Clathrin-coat disassembly illuminates the mechanisms of Hsp70 force generation

(2016) Rui Sousa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An atomistic view of Hsp70 allosteric crosstalk: from the nucleotide to the substrate binding domain and back

(2016) Federica Chiappori et al.   Scientific Reports

Targeting Hsp90/Hsp70-Based Protein Quality Control for Treatment of Adult Onset Neurodegenerative Diseases

(2015) William B. Pratt et al.   Annual Review of Pharmacology and Toxicology

Modulation of the Chaperone DnaK Allosterism by the Nucleotide Exchange Factor GrpE

(2015) Roberto Melero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How Hsp70 Molecular Machines Interact with Their Substrates to Mediate Diverse Physiological Functions

(2015) Eugenia M. Clerico et al.   JOURNAL OF MOLECULAR BIOLOGY

Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils

(2015) Xuechao Gao et al.   MOLECULAR CELL

Heterogeneous binding of the SH3 client protein to the DnaK molecular chaperone

(2015) Jung Ho Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleotides regulate the mechanical hierarchy between subdomains of the nucleotide binding domain of the Hsp70 chaperone DnaK

(2015) Daniela Bauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping the conformation of a client protein through the Hsp70 functional cycle

(2015) Ashok Sekhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate-binding domain conformational dynamics mediate Hsp70 allostery

(2015) Anastasia Zhuravleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cysteine string protein (CSP) and its role in preventing neurodegeneration

(2015) Robert D. Burgoyne et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Close and Allosteric Opening of the Polypeptide-Binding Site in a Human Hsp70 Chaperone BiP

(2015) Jiao Yang et al.   STRUCTURE

Pathways of allosteric regulation in Hsp70 chaperones

(2015) Roman Kityk et al.   Nature Communications

Screening strategies to identify HSP70 modulators to treat Alzheimer’s disease

(2015) Jayanthi Repalli et al.   Drug Design Development and Therapy

Hsp70 Forms Antiparallel Dimers Stabilized by Post-translational Modifications to Position Clients for Transfer to Hsp90

(2015) Nina Morgner et al.   Cell Reports

BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta

(2014) Melania Minoia et al.   Autophagy

Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles

(2014) Elaine Kirschke et al.   CELL

Barcoding heat shock proteins to human diseases: looking beyond the heat shock response

(2014) V. Kakkar et al.   Disease Models & Mechanisms

Single-molecule spectroscopy reveals chaperone-mediated expansion of substrate protein

(2014) Ruth Kellner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Key Interactions for Clathrin Coat Stability

(2014) Till Böcking et al.   STRUCTURE

J protein mutations and resulting proteostasis collapse

(2014) Carolina Koutras et al.   Frontiers in Cellular Neuroscience

Structural characterization of the substrate transfer mechanism in Hsp70/Hsp90 folding machinery mediated by Hop

(2014) Sara Alvira et al.   Nature Communications

ATPase Subdomain IA Is a Mediator of Interdomain Allostery in Hsp70 Molecular Chaperones

(2014) Ignacio J. General et al.   PLoS Computational Biology

Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis

(2013) Anja Bruchmann et al.   BMC CANCER

Co-translational mechanisms of protein maturation

(2013) Felix Gloge et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The DNAJB6 and DNAJB8 Protein Chaperones Prevent Intracellular Aggregation of Polyglutamine Peptides

(2013) Judith Gillis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of Human Nucleotide Exchange Factors to Heat Shock Protein 70 (Hsp70) Generates Functionally Distinct Complexesin Vitro

(2013) Jennifer N. Rauch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp110 Is aBona FideChaperone Using ATP to Unfold Stable Misfolded Polypeptides and Reciprocally Collaborate with Hsp70 to Solubilize Protein Aggregates

(2013) Rayees U. H. Mattoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Studies on the Forward and Reverse Binding Modes of Peptides to the Chaperone DnaK

(2013) Michael Zahn et al.   JOURNAL OF MOLECULAR BIOLOGY

Sequential Duplications of an Ancient Member of the DnaJ-Family Expanded the Functional Chaperone Network in the Eukaryotic Cytosol

(2013) Chandan Sahi et al.   MOLECULAR BIOLOGY AND EVOLUTION

Cotranslational Response to Proteotoxic Stress by Elongation Pausing of Ribosomes

(2013) Botao Liu et al.   MOLECULAR CELL

Widespread Regulation of Translation by Elongation Pausing in Heat Shock

(2013) Reut Shalgi et al.   MOLECULAR CELL

Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP

(2013) Ruifeng Qi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of Key Hinge Residues Important for Nucleotide-Dependent Allostery in E. coli Hsp70/DnaK

(2013) Peter Man-Un Ung et al.   PLoS Computational Biology

Decipher the Mechanisms of Protein Conformational Changes Induced by Nucleotide Binding through Free-Energy Landscape Analysis: ATP Binding to Hsp70

(2013) Adrien Nicolaï et al.   PLoS Computational Biology

Molecular chaperone involvement in chloroplast protein import

(2012) Úrsula Flores-Pérez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

An Interdomain Energetic Tug-of-War Creates the Allosterically Active State in Hsp70 Molecular Chaperones

(2012) Anastasia Zhuravleva et al.   CELL

Hsp70 Protein Complexes as Drug Targets

(2012) Victoria A. Assimon et al.   CURRENT PHARMACEUTICAL DESIGN

Metazoan Hsp70 machines use Hsp110 to power protein disaggregation

(2012) Heike Rampelt et al.   EMBO JOURNAL

Crystal Structure of DnaK Protein Complexed with Nucleotide Exchange Factor GrpE in DnaK Chaperone System

(2012) Ching-Chung Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational Selection in Substrate Recognition by Hsp70 Chaperones

(2012) Moritz Marcinowski et al.   JOURNAL OF MOLECULAR BIOLOGY

Unfolding of the C-Terminal Domain of the J-Protein Zuo1 Releases Autoinhibition and Activates Pdr1-Dependent Transcription

(2012) Jeanette K. Ducett et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones

(2012) Roman Kityk et al.   MOLECULAR CELL

Global analysis of chaperone effects using a reconstituted cell-free translation system

(2012) T. Niwa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient interactions of a slow-folding protein with the Hsp70 chaperone machinery

(2012) Ashok Sekhar et al.   PROTEIN SCIENCE

DnaK Functions as a Central Hub in the E. coli Chaperone Network

(2012) Giulia Calloni et al.   Cell Reports

Structural analysis of the Sil1–Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor

(2011) Ming Yan et al.   BIOCHEMICAL JOURNAL

Conserved, Disordered C Terminus of DnaK Enhances Cellular Survival upon Stress and DnaKin VitroChaperone Activity

(2011) Robert G. Smock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unique Peptide Substrate Binding Properties of 110-kDa Heat-shock Protein (Hsp110) Determine Its Distinct Chaperone Activity

(2011) Xinping Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein targeting and degradation are coupled for elimination of mislocalized proteins

(2011) Tara Hessa et al.   NATURE

Single-molecule analysis of a molecular disassemblase reveals the mechanism of Hsc70-driven clathrin uncoating

(2011) Till Böcking et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions

(2011) Moritz Marcinowski et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanics of Hsp70 chaperones enables differential interaction with client proteins

(2011) Rainer Schlecht et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-Free System

(2011) James Shorter   PLoS One

Allosteric signal transmission in the nucleotide-binding domain of 70-kDa heat shock protein (Hsp70) molecular chaperones

(2011) A. Zhuravleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bag1 directly routes immature BCR-ABL for proteasomal degradation

(2010) F. Tsukahara et al.   BLOOD

Bcl-2 proteins regulate ER membrane permeability to luminal proteins during ER stress-induced apoptosis

(2010) X Wang et al.   CELL DEATH AND DIFFERENTIATION

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)

(2010) Valeria Crippa et al.   HUMAN MOLECULAR GENETICS

Mutagenesis Reveals the Complex Relationships between ATPase Rate and the Chaperone Activities ofEscherichia coliHeat Shock Protein 70 (Hsp70/DnaK)

(2010) Lyra Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Directed Evolution of the DnaK Chaperone: Mutations in the Lid Domain Result in Enhanced Chaperone Activity

(2010) Raphael A. Aponte et al.   JOURNAL OF MOLECULAR BIOLOGY

A DNAJB Chaperone Subfamily with HDAC-Dependent Activities Suppresses Toxic Protein Aggregation

(2010) Jurre Hageman et al.   MOLECULAR CELL

The Conformational Dynamics of the Mitochondrial Hsp70 Chaperone

(2010) Koyeli Mapa et al.   MOLECULAR CELL

The kinetic parameters and energy cost of the Hsp70 chaperone as a polypeptide unfoldase

(2010) Sandeep K Sharma et al.   Nature Chemical Biology

Cellular strategies for controlling protein aggregation

(2010) Jens Tyedmers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The C-Terminal BAG Domain of BAG5 Induces Conformational Changes of the Hsp70 Nucleotide- Binding Domain for ADP-ATP Exchange

(2010) Akihiko Arakawa et al.   STRUCTURE

Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly

(2009) Yi Xing et al.   EMBO JOURNAL

Arabidopsis thaliana J-class heat shock proteins: cellular stress sensors

(2009) Vinoth Babu V. Rajan et al.   FUNCTIONAL & INTEGRATIVE GENOMICS

Allostery in Hsp70 Chaperones Is Transduced by Subdomain Rotations

(2009) Akash Bhattacharya et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of a consensus motif in substrates bound by a Type I Hsp40

(2009) P. Kota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate

(2009) E. B. Bertelsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accurate Prediction of DnaK-Peptide Binding via Homology Modelling and Experimental Data

(2009) Joost Van Durme et al.   PLoS Computational Biology

Nonnative Helical Motif in a Chaperone-Bound Protein Fragment

(2008) Neşe Kurt et al.   BIOPHYSICAL JOURNAL

Structural Basis for the Cooperation of Hsp70 and Hsp110 Chaperones in Protein Folding

(2008) Sigrun Polier et al.   CELL

Molecular Basis for Regulation of the Heat Shock Transcription Factor σ32 by the DnaK and DnaJ Chaperones

(2008) Fernanda Rodriguez et al.   MOLECULAR CELL

Structure of the Hsp110:Hsc70 Nucleotide Exchange Machine

(2008) Jonathan P. Schuermann et al.   MOLECULAR CELL

Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2

(2008) Zhen Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY