Non-canonical Interactions between Heat Shock Cognate Protein 70 (Hsc70) and Bcl2-associated Anthanogene (BAG) Co-Chaperones Are Important for Client Release

Hsp70 biases the folding pathways of client proteins

(2016) Ashok Sekhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation

(2015) Victoria A. Assimon et al.   BIOCHEMISTRY

Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection

(2015) Shuhei Taguwa et al.   CELL

Modulation of the Chaperone DnaK Allosterism by the Nucleotide Exchange Factor GrpE

(2015) Roberto Melero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The nucleotide exchange factors Grp170 and Sil1 induce cholera toxin release from BiP to enable retrotranslocation

(2015) Jeffrey M. Williams et al.   MOLECULAR BIOLOGY OF THE CELL

Pathways of allosteric regulation in Hsp70 chaperones

(2015) Roman Kityk et al.   Nature Communications

Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles

(2014) Elaine Kirschke et al.   CELL

Hierarchical Functional Specificity of Cytosolic Heat Shock Protein 70 (Hsp70) Nucleotide Exchange Factors in Yeast

(2014) Jennifer L. Abrams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperone

(2014) Joseph Amick et al.   PROTEIN SCIENCE

ATPase Subdomain IA Is a Mediator of Interdomain Allostery in Hsp70 Molecular Chaperones

(2014) Ignacio J. General et al.   PLoS Computational Biology

Inhibitors of Difficult Protein–Protein Interactions Identified by High-Throughput Screening of Multiprotein Complexes

(2013) Laura C. Cesa et al.   ACS Chemical Biology

The E3 Ubiquitin Ligase CHIP and the Molecular Chaperone Hsc70 Form a Dynamic, Tethered Complex

(2013) Matthew C. Smith et al.   BIOCHEMISTRY

Binding of Human Nucleotide Exchange Factors to Heat Shock Protein 70 (Hsp70) Generates Functionally Distinct Complexesin Vitro

(2013) Jennifer N. Rauch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp110 Is aBona FideChaperone Using ATP to Unfold Stable Misfolded Polypeptides and Reciprocally Collaborate with Hsp70 to Solubilize Protein Aggregates

(2013) Rayees U. H. Mattoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP

(2013) Ruifeng Qi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Analysis of the Tau-Associated Proteome Reveals That Exchange of Hsp70 for Hsp90 Is Involved in Tau Degradation

(2012) Andrea D. Thompson et al.   ACS Chemical Biology

Hsp70 Protein Complexes as Drug Targets

(2012) Victoria A. Assimon et al.   CURRENT PHARMACEUTICAL DESIGN

Imbalance of Hsp70 family variants fosters tau accumulation

(2012) Umesh K. Jinwal et al.   FASEB JOURNAL

C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances

(2012) P Muller et al.   ONCOGENE

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities

(2011) Jurre Hageman et al.   BIOCHEMICAL JOURNAL

Chemical Screens against a Reconstituted Multiprotein Complex: Myricetin Blocks DnaJ Regulation of DnaK through an Allosteric Mechanism

(2011) Lyra Chang et al.   CHEMISTRY & BIOLOGY

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Ubiquitinylation of α-Synuclein by Carboxyl Terminus Hsp70-Interacting Protein (CHIP) Is Regulated by Bcl-2-Associated Athanogene 5 (BAG5)

(2011) Lorraine V. Kalia et al.   PLoS One

The Hsc/Hsp70 Co-Chaperone Network Controls Antigen Aggregation and Presentation during Maturation of Professional Antigen Presenting Cells

(2011) Nadja Kettern et al.   PLoS One

Bag1 directly routes immature BCR-ABL for proteasomal degradation

(2010) F. Tsukahara et al.   BLOOD

An interdomain sector mediating allostery in Hsp70 molecular chaperones

(2010) Robert G Smock et al.   Molecular Systems Biology

The C-Terminal BAG Domain of BAG5 Induces Conformational Changes of the Hsp70 Nucleotide- Binding Domain for ADP-ATP Exchange

(2010) Akihiko Arakawa et al.   STRUCTURE

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

(2009) Martin Gamerdinger et al.   EMBO JOURNAL

The Cochaperone BAG2 Sweeps Paired Helical Filament- Insoluble Tau from the Microtubule

(2009) D. C. Carrettiero et al.   JOURNAL OF NEUROSCIENCE

Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate

(2009) E. B. Bertelsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accurate Prediction of DnaK-Peptide Binding via Homology Modelling and Experimental Data

(2009) Joost Van Durme et al.   PLoS Computational Biology

The BAG proteins: a ubiquitous family of chaperone regulators

(2008) M. Kabbage et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hsp110 Is a Nucleotide-activated Exchange Factor for Hsp70

(2008) Claes Andréasson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2

(2008) Zhen Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY