Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease

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Genetic effects on gene expression across human tissues

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Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

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Association analyses based on false discovery rate implicate new loci for coronary artery disease

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Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice

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Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

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Characterization of the direct targets of FOXO transcription factors throughout evolution

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Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation ofLMOD1, SYNPO2, PDLIM7, PLN, andSYNMHighlights

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Network-Based Identification and Prioritization of Key Regulators of Coronary Artery Disease LociSignificance

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FINEMAP: efficient variable selection using summary data from genome-wide association studies

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Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective

(2016) Olga A Cherepanova et al.   NATURE MEDICINE

Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases

(2016) O. Franzen et al.   SCIENCE

Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci

(2016) Clint L. Miller et al.   Nature Communications

Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery DiseaseSignificance

(2015) Sujoy Ghosh et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CDKN2B Regulates TGF β Signaling and Smooth Muscle Cell Investment of Hypoxic NeovesselsNovelty and Significance

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Leiomodin-3-deficient mice display nemaline myopathy with fast-myofiber atrophy

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Genome-wide association studies identify genetic loci for low von Willebrand factor levels

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Gene expression signatures, pathways and networks in carotid atherosclerosis

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A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

(2015) Majid Nikpay et al.   NATURE GENETICS

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

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HaploReg v4: systematic mining of putative causal variants, cell types, regulators and target genes for human complex traits and disease

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Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap

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Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci

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Dissecting the Causal Genetic Mechanisms of Coronary Heart Disease

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Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy

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Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis

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Genetic and epigenetic fine mapping of causal autoimmune disease variants

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Integrating Functional Data to Prioritize Causal Variants in Statistical Fine-Mapping Studies

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Coronary Heart Disease-Associated Variation in TCF21 Disrupts a miR-224 Binding Site and miRNA-Mediated Regulation

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Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease

(2014) Ville-Petteri Mäkinen et al.   PLoS Genetics

Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits

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Discovery and refinement of loci associated with lipid levels

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The Genotype-Tissue Expression (GTEx) project

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Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

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Large-scale association analysis identifies new risk loci for coronary artery disease

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Leiomodin 1, a New Serum Response Factor-dependent Target Gene Expressed Preferentially in Differentiated Smooth Muscle Cells

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Leiomodin-2 is an antagonist of tropomodulin-1 at the pointed end of the thin filaments in cardiac muscle

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The NIH Roadmap Epigenomics Mapping Consortium

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Apelin is necessary for the maintenance of insulin sensitivity

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The Transcription of FOXO Genes Is Stimulated by FOXO3 and Repressed by Growth Factors

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Leiomodin Is an Actin Filament Nucleator in Muscle Cells

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