Development of a neurotoxicity assay that is tuned to detect mitochondrial toxicants

The cytochrome bc 1 complex inhibitor Ametoctradin has an unusual binding mode

(2018) Adalbert Dreinert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Correlation of structural features of novel 1,2,3-triazoles with their neurotoxic and tumoricidal properties

(2018) Elaine Maria de Souza-Fagundes et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Metabolic and Phenotypic Characterization of Human Skin Fibroblasts After Forcing Oxidative Capacity

(2018) Susana P Pereira et al.   TOXICOLOGICAL SCIENCES

Testing for developmental neurotoxicity using a battery of in vitro assays for key cellular events in neurodevelopment

(2018) Joshua A. Harrill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

In vitro screening of cell bioenergetics to assess mitochondrial dysfunction in drug development

(2018) K. Tilmant et al.   TOXICOLOGY IN VITRO

A strategy for systemic toxicity assessment based on non-animal approaches: The Cosmetics Europe Long Range Science Strategy programme

(2018) Bertrand Desprez et al.   TOXICOLOGY IN VITRO

Integrated ‘omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes

(2018) Jarno E.J. Wolters et al.   TOXICOLOGY LETTERS

Canagliflozin mediated dual inhibition of mitochondrial glutamate dehydrogenase and complex I: an off-target adverse effect

(2018) Philipp F. Secker et al.   Cell Death & Disease

A high-throughput approach to identify specific neurotoxicants / developmental toxicants in human neuronal cell function assays

(2018) Johannes Delp   ALTEX-Alternatives to Animal Experimentation

Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies

(2018) Menghang Xia et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift

(2018) Simon Gutbier et al.   ARCHIVES OF TOXICOLOGY

Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress

(2018) Simon Gutbier et al.   CELL DEATH AND DIFFERENTIATION

Evaluation of in Vitro Mitochondrial Toxicity Assays and Physicochemical Properties for Prediction of Organ Toxicity Using 228 Pharmaceutical Drugs

(2018) Payal Rana et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Mannose impairs tumour growth and enhances chemotherapy

(2018) Pablo Sierra Gonzalez et al.   NATURE

Mice deficient in L-12/15 lipoxygenase show increased vulnerability to 3-nitropropionic acid neurotoxicity

(2017) Yan He et al.   NEUROSCIENCE LETTERS

Neural mechanisms of functional impairment across the lifespan

(2017) Christoph van Thriel et al.   NEUROTOXICOLOGY

Carbon monoxide and anesthesia-induced neurotoxicity

(2017) Richard J. Levy   NEUROTOXICOLOGY AND TERATOLOGY

From the Cover: Developmental Neurotoxicants Disrupt Activity in Cortical Networks on Microelectrode Arrays: Results of Screening 86 Compounds During Neural Network Formation

(2017) Christopher L. Frank et al.   TOXICOLOGICAL SCIENCES

Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity

(2017) Johannes Delp et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Tipping Points and Endogenous Determinants of Nigrostriatal Degeneration by MPTP

(2017) Stefan Schildknecht et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Traditional and novel tools to probe the mitochondrial metabolism in health and disease

(2017) Yanfei Zhang et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

A transcriptomics data-driven gene space accurately predicts liver cytopathology and drug-induced liver injury

(2017) Pekka Kohonen et al.   Nature Communications

Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man

(2016) Sanja Dragovic et al.   ARCHIVES OF TOXICOLOGY

In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities

(2016) Béla Z. Schmidt et al.   ARCHIVES OF TOXICOLOGY

A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation

(2016) Jason D. Arroyo et al.   Cell Metabolism

Characterization of three human cell line models for high-throughput neuronal cytotoxicity screening

(2016) Zhi-Bin Tong et al.   JOURNAL OF APPLIED TOXICOLOGY

A combined in vitro approach to improve the prediction of mitochondrial toxicants

(2016) Julie Eakins et al.   TOXICOLOGY IN VITRO

Stem Cell-Derived Immature Human Dorsal Root Ganglia Neurons to Identify Peripheral Neurotoxicants

(2016) Lisa Hoelting et al.   Stem Cells Translational Medicine

International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes

(2015) Anna Bal-Price et al.   ARCHIVES OF TOXICOLOGY

Mitochondrial dysfunction in fatty acid oxidation disorders: insights from human and animal studies

(2015) M. Wajner et al.   BIOSCIENCE REPORTS

Prevention of the degeneration of human dopaminergic neurons in an astrocyte co-culture system allowing endogenous drug metabolism

(2015) Liudmila Efremova et al.   BRITISH JOURNAL OF PHARMACOLOGY

Metabolic changes associated with tumor metastasis, part 2: Mitochondria, lipid and amino acid metabolism

(2015) Paolo E. Porporato et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Toxicology Strategies for Drug Discovery: Present and Future

(2015) Eric A. G. Blomme et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Putative adverse outcome pathways relevant to neurotoxicity

(2015) Anna Bal-Price et al.   CRITICAL REVIEWS IN TOXICOLOGY

Novel scalable 3D cell based model for in vitro neurotoxicity testing: Combining human differentiated neurospheres with gene expression and functional endpoints

(2015) Ana Paula Terrasso et al.   JOURNAL OF BIOTECHNOLOGY

Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

(2015) W. Senkowski et al.   MOLECULAR CANCER THERAPEUTICS

The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death

(2015) Laleh Kamalian et al.   TOXICOLOGY IN VITRO

Evaluation of drug-induced neurotoxicity based on metabolomics, proteomics and electrical activity measurements in complementary CNS in vitro models

(2015) Luise Schultz et al.   TOXICOLOGY IN VITRO

In vitro models for neurotoxicology research

(2015) Daniel José Barbosa et al.   Toxicology Research

Aerobic Glycolysis: Beyond Proliferation

(2015) William Jones et al.   Frontiers in Immunology

A comparison of the in vitro cyto- and neurotoxicity of brominated and halogen-free flame retardants: prioritization in search for safe(r) alternatives

(2014) Hester S. Hendriks et al.   ARCHIVES OF TOXICOLOGY

SEURAT-1 liver gold reference compounds: a mechanism-based review

(2014) Paul Jennings et al.   ARCHIVES OF TOXICOLOGY

Mitochondrial toxicity assessment in industry – a decade of technology development and insight

(2014) Yvonne Will et al.   Expert Opinion on Drug Metabolism & Toxicology

Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

(2014) Michael D. Aleo et al.   HEPATOLOGY

Mitochondrial cholesterol: mechanisms of import and effects on mitochondrial function

(2014) Laura A. Martin et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis

(2014) Joshua K Salabei et al.   Nature Protocols

Multiparametric High Content Analysis for assessment of neurotoxicity in differentiated neuronal cell lines and human embryonic stem cell-derived neurons

(2014) Melinda S. Wilson et al.   NEUROTOXICOLOGY

Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP+

(2014) A K Krug et al.   Cell Death & Disease

Generation of genetically-modified human differentiated cells for toxicological tests and the study of neurodegenerative diseases

(2014) Stefan Schildknecht   ALTEX-Alternatives to Animal Experimentation

Modulation of mitochondrial bioenergetics in a skeletal muscle cell line model of mitochondrial toxicity

(2014) William Dott et al.   Redox Biology

Evaluation of a human neurite growth assay as specific screen for developmental neurotoxicants

(2013) Anne K. Krug et al.   ARCHIVES OF TOXICOLOGY

Comparative Kinetics ofQiSite Inhibitors of Cytochromebc1Complex: Picomolar Antimycin and Micromolar Cyazofamid

(2013) Hui Li et al.   Chemical Biology & Drug Design

Validation of a HTS-amenable assay to detect drug-induced mitochondrial toxicity in the absence and presence of cell death

(2013) Rachel Swiss et al.   TOXICOLOGY IN VITRO

Assessment of drug-induced mitochondrial dysfunction via altered cellular respiration and acidification measured in a 96-well platform

(2012) Sashi Nadanaciva et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Mitochondrial bioenergetics and drug-induced toxicity in a panel of mouse embryonic fibroblasts with mitochondrial DNA single nucleotide polymorphisms

(2012) Claudia V. Pereira et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Selection of test methods to be included in a testing strategy to predict acute oral toxicity: An approach based on statistical analysis of data collected in phase 1 of the ACuteTox project

(2012) A. Kinsner-Ovaskainen et al.   TOXICOLOGY IN VITRO

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Central role of mitochondria in drug-induced liver injury

(2011) Dominique Pessayre et al.   DRUG METABOLISM REVIEWS

Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line

(2011) Diana Scholz et al.   JOURNAL OF NEUROCHEMISTRY

Uncoupling of ATP-depletion and cell death in human dopaminergic neurons

(2011) Dominik Pöltl et al.   NEUROTOXICOLOGY

Sensitivity of Dopaminergic Neuron Differentiation from Stem Cells to Chronic Low-Dose Methylmercury Exposure

(2011) Bastian Zimmer et al.   TOXICOLOGICAL SCIENCES

Assessment of Chemical-Induced Impairment of Human Neurite Outgrowth by Multiparametric Live Cell Imaging in High-Density Cultures

(2011) Nina V. Stiegler et al.   TOXICOLOGICAL SCIENCES

Comparative sensitivity of human and rat neural cultures to chemical-induced inhibition of neurite outgrowth

(2011) Joshua A. Harrill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver

(2010) Karima Begriche et al.   JOURNAL OF HEPATOLOGY

Salinomycin in cancer: A new mission for an old agent

(2010) Naujokat   Molecular Medicine Reports

Neurofunctional endpoints assessed in human neuroblastoma SH-SY5Y cells for estimation of acute systemic toxicity

(2010) Helena Gustafsson et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Quantitative Microplate-Based Respirometry with Correction for Oxygen Diffusion

(2009) Akos A. Gerencser et al.   ANALYTICAL CHEMISTRY

Characterization of sensitivity of Rhizoctonia solani, causing rice sheath blight, to mepronil and boscalid

(2009) C.Q. Zhang et al.   CROP PROTECTION

A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A

(2009) Linda P.C. Yu et al.   STRUCTURE

Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells

(2009) Stefan Schildknecht et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Neuronal in vitro models for the estimation of acute systemic toxicity

(2009) A. Forsby et al.   TOXICOLOGY IN VITRO

The use of Fluoro-Jade in primary neuronal cell cultures

(2008) Gabriele Schmuck et al.   ARCHIVES OF TOXICOLOGY