Pilot Study of an Integrative New Tool for Studying Clinical Outcome Discrimination in Acute Leukemia

The molecular signature of AML with increased ALDH activity suggests a stem cell origin

(2018) Rachel Blume et al.   LEUKEMIA & LYMPHOMA

Zebrafish xenograft models of cancer and metastasis for drug discovery

(2017) Hannah K Brown et al.   Expert Opinion on Drug Discovery

Acute lymphoblastic leukemia cells create a leukemic niche without affecting the CXCR4/CXCL12 axis

(2017) Bob de Rooij et al.   HAEMATOLOGICA

Phenotypic and Functional Alterations of Hematopoietic Stem and Progenitor Cells in an In Vitro Leukemia-Induced Microenvironment

(2017) Jean-Paul Vernot et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Differential Functional Roles of ALDH1A1 and ALDH1A3 in Mediating Metastatic Behavior and Therapy Resistance of Human Breast Cancer Cells

(2017) Alysha Croker et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characterization of prostate cancer cell progression in zebrafish xenograft model

(2017) Wei Xu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Efforts to enhance blood stem cell engraftment: Recent insights from zebrafish hematopoiesis

(2017) Julie R. Perlin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An improved pre-clinical patient-derived liquid xenograft mouse model for acute myeloid leukemia

(2017) Zhisheng Her et al.   Journal of Hematology & Oncology

Acute Myeloid Leukemia, Version 3.2017, NCCN Clinical Practice Guidelines in Oncology

(2017) Margaret R. O'Donnell et al.   Journal of the National Comprehensive Cancer Network

Understanding of leukemic stem cells and their clinical implications

(2017) Xuefei Wang et al.   Molecular Cancer

Single-cell functional and chemosensitive profiling of combinatorial colorectal therapy in zebrafish xenografts

(2017) Rita Fior et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of SOX4 correlates with poor prognosis of acute myeloid leukemia and is leukemogenic in zebrafish

(2017) J-W Lu et al.   Blood Cancer Journal

Acute lymphoblastic leukemia: a comprehensive review and 2017 update

(2017) T Terwilliger et al.   Blood Cancer Journal

Zebrafish Caudal Haematopoietic Embryonic Stromal Tissue (CHEST) Cells Support Haematopoiesis

(2017) Anja Wolf et al.   Scientific Reports

Acute lymphoblastic leukemia cells create a leukemic niche without affecting the CXCR4/CXCL12 axis

(2017) Bob de Rooij et al.   HAEMATOLOGICA

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

(2016) Elizabeth C. Townsend et al.   CANCER CELL

Cancer Cell Dissemination and Homing to the Bone Marrow in a Zebrafish Model

(2016) Antonio Sacco et al.   CANCER RESEARCH

Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche

(2016) Haobin Ye et al.   Cell Stem Cell

Inhibition of signaling between human CXCR4 and zebrafish ligands by the small molecule IT1t impairs the formation of triple-negative breast cancer early metastases in a zebrafish xenograft model

(2016) Claudia Tulotta et al.   Disease Models & Mechanisms

CRISPR/Cas9 in zebrafish: an efficient combination for human genetic diseases modeling

(2016) Jiaqi Liu et al.   HUMAN GENETICS

High expression of ID family and IGJ genes signature as predictor of low induction treatment response and worst survival in adult Hispanic patients with B-acute lymphoblastic leukemia

(2016) Nataly Cruz-Rodriguez et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Novel immunologic tolerance of human cancer cell xenotransplants in zebrafish

(2016) Beibei Zhang et al.   Translational Research

Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish

(2016) Qin Tang et al.   Nature Communications

Aldehyde dehydrogenases inhibition eradicates leukemia stem cells while sparing normal progenitors

(2016) G Venton et al.   Blood Cancer Journal

Testing the Vascular Invasive Ability of Cancer Cells in Zebrafish (Danio Rerio)

(2016) Eric B. Berens et al.   Jove-Journal of Visualized Experiments

Acute lymphoblastic leukemia: an assessment of international incidence, survival, and disease burden

(2015) Aaron J. Katz et al.   CANCER CAUSES & CONTROL

Hematopoietic Stem Cell Arrival Triggers Dynamic Remodeling of the Perivascular Niche

(2015) Owen J. Tamplin et al.   CELL

Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities

(2015) Koen Schepers et al.   Cell Stem Cell

Zebrafish: A New Companion for Translational Research in Oncology

(2015) J. Barriuso et al.   CLINICAL CANCER RESEARCH

The rarity of ALDH+cells is the key to separation of normal versus leukemia stem cells by ALDH activity in AML patients

(2015) Van T. Hoang et al.   INTERNATIONAL JOURNAL OF CANCER

Zebrafish as a model for leukemia and other hematopoietic disorders

(2015) Parisa Rasighaemi et al.   Journal of Hematology & Oncology

Clonal Evolution Enhances Leukemia-Propagating Cell Frequency in T Cell Acute Lymphoblastic Leukemia through Akt/mTORC1 Pathway Activation

(2014) Jessica S. Blackburn et al.   CANCER CELL

Zebrafish models in translational research: tipping the scales toward advancements in human health

(2014) J. B. Phillips et al.   Disease Models & Mechanisms

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

(2014) Liran I. Shlush et al.   NATURE

Zebrafish embryo as a tool to study tumor/endothelial cell cross-talk

(2013) Chiara Tobia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The role of aldehyde dehydrogenase (ALDH) in cancer drug resistance

(2013) Radosław Januchowski et al.   BIOMEDICINE & PHARMACOTHERAPY

Significance of FAB subclassification of "acute myeloid leukemia, NOS" in the 2008 WHO classification: analysis of 5848 newly diagnosed patients

(2013) R. B. Walter et al.   BLOOD

Evaluating human cancer cell metastasis in zebrafish

(2013) Yong Teng et al.   BMC CANCER

Zebrafish (Danio rerio) as a model for the study of aging and exercise: Physical ability and trainability decrease with age

(2013) Matthew J.H. Gilbert et al.   EXPERIMENTAL GERONTOLOGY

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

The zebrafish as a tool in leukemia research

(2012) Kaisa J. Teittinen et al.   LEUKEMIA RESEARCH

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

A Novel Zebrafish Embryo Xenotransplantation Model to Study Primary Human Fibroblast Motility in Health and Disease

(2012) Alexey O. Benyumov et al.   Zebrafish

The Initial Hours of Metastasis: The Importance of Cooperative Host-Tumor Cell Interactions during Hematogenous Dissemination

(2012) M. Labelle et al.   Cancer Discovery

Regular Care and Maintenance of a Zebrafish (Danio rerio) Laboratory: An Introduction

(2012) Avdesh Avdesh et al.   Jove-Journal of Visualized Experiments

Stromal cell-derived factor-1 and hematopoietic cell homing in an adult zebrafish model of hematopoietic cell transplantation

(2011) T. J. Glass et al.   BLOOD

The identification and characterization of zebrafish hematopoietic stem cells

(2011) D. Ma et al.   BLOOD

Leukaemia xenotransplantation in zebrafish - chemotherapy response assay in vivo

(2011) Dale P. Corkery et al.   BRITISH JOURNAL OF HAEMATOLOGY

Zebrafish as a model for normal and malignant hematopoiesis

(2011) L. Jing et al.   Disease Models & Mechanisms

Heterogeneity of leukemia stem cell candidates at diagnosis of acute myeloid leukemia and their clinical significance

(2011) Dan Ran et al.   EXPERIMENTAL HEMATOLOGY

Leukemic cell xenograft in zebrafish embryo for investigating drug efficacy

(2011) B. Pruvot et al.   HAEMATOLOGICA

Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer

(2011) Bao-Hong Guo et al.   Molecular Cancer

Stem cell gene expression programs influence clinical outcome in human leukemia

(2011) Kolja Eppert et al.   NATURE MEDICINE

Shared acquired genomic changes in zebrafish and human T-ALL

(2011) L A Rudner et al.   ONCOGENE

Identification of Hepatic Niche Harboring Human Acute Lymphoblastic Leukemic Cells via the SDF-1/CXCR4 Axis

(2011) Itaru Kato et al.   PLoS One

Discriminating Different Cancer Cells Using a Zebrafish in Vivo Assay

(2011) Karni S. Moshal et al.   Cancers

High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia

(2010) A. C. H. Smith et al.   BLOOD

Adult acute lymphoblastic leukemia

(2010) Stefan Faderl et al.   CANCER

The cancer stem cell paradigm: a new understanding of tumor development and treatment

(2010) Johnathan D Ebben et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Visualizing extravasation dynamics of metastatic tumor cells

(2010) K. Stoletov et al.   JOURNAL OF CELL SCIENCE

Genetic variegation of clonal architecture and propagating cells in leukaemia

(2010) Kristina Anderson et al.   NATURE

Metastatic behaviour of primary human tumours in a zebrafish xenotransplantation model

(2009) Ines J Marques et al.   BMC CANCER

Aldehyde dehydrogenase activity among primary leukemia cells is associated with stem cell features and correlates with adverse clinical outcomes

(2009) Dan Ran et al.   EXPERIMENTAL HEMATOLOGY

Live imaging early immune cell ontogeny and function in zebrafishDanio rerio

(2008) C. J. Hall et al.   JOURNAL OF FISH BIOLOGY