Zebrafish as a model for leukemia and other hematopoietic disorders

Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia

(2014) B.-L. He et al.   BLOOD

A transgenic zebrafish model expressingKIT-D816V recapitulates features of aggressive systemic mastocytosis

(2014) Tugce B. Balci et al.   BRITISH JOURNAL OF HAEMATOLOGY

ETV6 (TEL1) regulates embryonic hematopoiesis in zebrafish

(2014) P. Rasighaemi et al.   HAEMATOLOGICA

Focused chemical genomics using zebrafish xenotransplantation as a pre-clinical therapeutic platform for T-cell acute lymphoblastic leukemia

(2014) V. L. Bentley et al.   HAEMATOLOGICA

TET proteins and 5-methylcytosine oxidation in hematological cancers

(2014) Myunggon Ko et al.   IMMUNOLOGICAL REVIEWS

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia

(2014) Alejandro Gutierrez et al.   JOURNAL OF CLINICAL INVESTIGATION

Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia

(2014) C Reynolds et al.   LEUKEMIA

A Zebrafish Model of Myelodysplastic Syndrome Produced throughtet2Genomic Editing

(2014) Evisa Gjini et al.   MOLECULAR AND CELLULAR BIOLOGY

Activating Janus kinase pseudokinase domain mutations in myeloproliferative and other blood cancers

(2013) Stefan N. Constantinescu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish

(2013) S. Choorapoikayil et al.   BLOOD

Suppression of Pu.1 function results in expanded myelopoiesis in zebrafish

(2013) J Sun et al.   LEUKEMIA

Targeting oncogene expression to endothelial cells induces proliferation of the myelo-erythroid lineage by repressing the notch pathway

(2013) E Alghisi et al.   LEUKEMIA

Efficient genome editing in zebrafish using a CRISPR-Cas system

(2013) Woong Y Hwang et al.   NATURE BIOTECHNOLOGY

MYCN Transgenic Zebrafish Model with the Characterization of Acute Myeloid Leukemia and Altered Hematopoiesis

(2013) Li-Jing Shen et al.   PLoS One

SnapShot: Acute Myeloid Leukemia

(2012) Bernd B. Zeisig et al.   CANCER CELL

MYC oncogene in myeloid neoplasias

(2012) M. Dolores Delgado et al.   Clinical & Translational Oncology

Alternative TEL-JAK2 fusions associated with T-cell acute lymphoblastic leukemia and atypical chronic myelogenous leukemia dissected in zebrafish

(2012) S. M. N. Onnebo et al.   HAEMATOLOGICA

The significance of low PU.1 expression in patients with acute promyelocytic leukemia

(2012) Xuehua Zhu et al.   Journal of Hematology & Oncology

Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs

(2012) Lindsay Cade et al.   NUCLEIC ACIDS RESEARCH

Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBF  interaction

(2012) L. Cunningham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The developing zebrafish (Danio rerio): A vertebrate model for high-throughput screening of chemical libraries

(2011) Charles A. Lessman   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Ddx18 is essential for cell-cycle progression in zebrafish hematopoietic cells and is mutated in human AML

(2011) E. M. Payne et al.   BLOOD

NUP98-HOXA9-transgenic zebrafish develop a myeloproliferative neoplasm and provide new insight into mechanisms of myeloid leukaemogenesis

(2011) A. Michael Forrester et al.   BRITISH JOURNAL OF HAEMATOLOGY

The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy

(2011) P N Kelly et al.   CELL DEATH AND DIFFERENTIATION

RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis

(2011) Kentson Lam   Frontiers in Bioscience-Landmark

Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia

(2011) Alejandro Gutierrez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Shared acquired genomic changes in zebrafish and human T-ALL

(2011) L A Rudner et al.   ONCOGENE

An evolutionarily conserved PTEN-C/EBP -CTNNA1 axis controls myeloid development and transformation

(2010) C.-T. Fu et al.   BLOOD

High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia

(2010) A. C. H. Smith et al.   BLOOD

Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish

(2010) N. Bolli et al.   BLOOD

A new zebrafish model for experimental leukemia therapy

(2010) Igor V. Mizgirev et al.   CANCER BIOLOGY & THERAPY

T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation

(2010) Hui Feng et al.   CANCER CELL

Hematopoietic development in the zebrafish

(2010) Elizabeth J. Paik et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Small Molecule Screening in Zebrafish

(2010) David S. Peal et al.   Journal of Cardiovascular Translational Research

The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model

(2009) K. Cheng et al.   BLOOD

Zebrafish granulocyte colony-stimulating factor receptor signaling promotes myelopoiesis and myeloid cell migration

(2009) C. Liongue et al.   BLOOD

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

(2009) A. Gutierrez et al.   BLOOD

Definitive hematopoietic stem/progenitor cells manifest distinct differentiation output in the zebrafish VDA and PBI

(2009) H. Jin et al.   DEVELOPMENT

A novel zebrafish jak2aV581F model shared features of human JAK2V617F polycythemia vera

(2009) Alvin C.H. Ma et al.   EXPERIMENTAL HEMATOLOGY

Zebrafish blood stem cells

(2009) Aye T. Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Heritable T-cell malignancy models established in a zebrafish phenotypic screen

(2009) J K Frazer et al.   LEUKEMIA

Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications

(2009) B Falini et al.   LEUKEMIA

Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation

(2009) Jing-Ruey J Yeh et al.   Nature Chemical Biology

High-Throughput Sequencing of the Zebrafish Antibody Repertoire

(2009) J. A. Weinstein et al.   SCIENCE

A Primer for Morpholino Use in Zebrafish

(2009) Brent R. Bill et al.   Zebrafish

MOZ/TIF2-induced acute myeloid leukaemia in transgenic fish

(2008) Julia Zhuravleva et al.   BRITISH JOURNAL OF HAEMATOLOGY

Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis

(2008) Richard Mark White et al.   Cell Stem Cell

CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis

(2008) J. Y. Bertrand et al.   DEVELOPMENT