The cancer stem cell paradigm: a new understanding of tumor development and treatment

Brain Tumor Stem-Like Cells Identified by Neural Stem Cell Marker CD15

(2014) Xing-gang Mao et al.   Translational Oncology

Isolation of tumour stem-like cells from benign tumours

(2009) Q Xu et al.   BRITISH JOURNAL OF CANCER

Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse Model

(2009) Sheila Alcantara Llaguno et al.   CANCER CELL

Multipotent CD15+ Cancer Stem Cells in Patched-1-Deficient Mouse Medulloblastoma

(2009) R. J. Ward et al.   CANCER RESEARCH

Aldehyde Dehydrogenase 1 Is a Marker for Normal and Malignant Human Colonic Stem Cells (SC) and Tracks SC Overpopulation during Colon Tumorigenesis

(2009) E. H. Huang et al.   CANCER RESEARCH

Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution

(2009) Mark Shackleton et al.   CELL

SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma

(2009) Myung Jin Son et al.   Cell Stem Cell

Glioma Stem Cell Lines Expanded in Adherent Culture Have Tumor-Specific Phenotypes and Are Suitable for Chemical and Genetic Screens

(2009) Steven M. Pollard et al.   Cell Stem Cell

PTEN/PI3K/Akt Pathway Regulates the Side Population Phenotype and ABCG2 Activity in Glioma Tumor Stem-like Cells

(2009) Anne-Marie Bleau et al.   Cell Stem Cell

Wnt signalling and cancer stem cells

(2009) Jesús Espada et al.   Clinical & Translational Oncology

HER-2, Notch, and Breast Cancer Stem Cells: Targeting an Axis of Evil

(2009) H. Korkaya et al.   CLINICAL CANCER RESEARCH

Tumor-Initiating Cells of HER2-Positive Carcinoma Cell Lines Express the Highest Oncoprotein Levels and Are Sensitive to Trastuzumab

(2009) A. Magnifico et al.   CLINICAL CANCER RESEARCH

Aldehyde Dehydrogenase 1-Positive Cancer Stem Cells Mediate Metastasis and Poor Clinical Outcome in Inflammatory Breast Cancer

(2009) E. Charafe-Jauffret et al.   CLINICAL CANCER RESEARCH

Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo

(2009) Shenghui He et al.   DEVELOPMENTAL BIOLOGY

ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients’ outcome

(2009) Ting Li et al.   LABORATORY INVESTIGATION

Recurrence cancer stem cells – Made by cell fusion?

(2009) Thomas Dittmar et al.   MEDICAL HYPOTHESES

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Tumour-initiating cells: challenges and opportunities for anticancer drug discovery

(2009) Bin-Bing S. Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

(2009) Charles M. Rudin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiple Lineages of Human Breast Cancer Stem/Progenitor Cells Identified by Profiling with Stem Cell Markers

(2009) Wendy W. Hwang-Verslues et al.   PLoS One

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

(2009) R. L. Yauch et al.   SCIENCE

Proliferation of Human Glioblastoma Stem Cells Occurs Independently of Exogenous Mitogens

(2009) John J. P. Kelly et al.   STEM CELLS

NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity

(2008) F. Armstrong et al.   BLOOD

The Loss of Nf1 Transiently Promotes Self-Renewal but Not Tumorigenesis by Neural Crest Stem Cells

(2008) Nancy M. Joseph et al.   CANCER CELL

Significance of CD90+ Cancer Stem Cells in Human Liver Cancer

(2008) Zhen Fan Yang et al.   CANCER CELL

Crucial Role of Interleukin-4 in the Survival of Colon Cancer Stem Cells

(2008) M. G. Francipane et al.   CANCER RESEARCH

Cancer induction by restriction of oncogene expression to the stem cell compartment

(2008) María Pérez-Caro et al.   EMBO JOURNAL

PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo

(2008) D. Hambardzumyan et al.   GENES & DEVELOPMENT

Epidermal Growth Factor Plays a Crucial Role in Mitogenic Regulation of Human Brain Tumor Stem Cells

(2008) Akio Soeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability

(2008) Alysha K. Croker et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

CD34+CD38+CD19+ as well as CD34+CD38−CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL

(2008) Y Kong et al.   LEUKEMIA

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

PML targeting eradicates quiescent leukaemia-initiating cells

(2008) Keisuke Ito et al.   NATURE

Identification of cells initiating human melanomas

(2008) Tobias Schatton et al.   NATURE

Efficient tumour formation by single human melanoma cells

(2008) Elsa Quintana et al.   NATURE

Initiating and Cancer-Propagating Cells in TEL-AML1-Associated Childhood Leukemia

(2008) D. Hong et al.   SCIENCE