Regulation Is in the Air: The Relationship between Hypoxia and Epigenetics in Cancer

G1P3 (IFI6), a mitochondrial localised antiapoptotic protein, promotes metastatic potential of breast cancer cells through mtROS

(2018) Venugopalan Cheriyath et al.   BRITISH JOURNAL OF CANCER

Hypoxic-stabilized EPAS1 proteins transactivate DNMT1 and cause promoter hypermethylation and transcription inhibition of EPAS1 in non-small cell lung cancer

(2018) Xiang-Hong Xu et al.   FASEB JOURNAL

Overexpression of ELF3 facilitates cell growth and metastasis through PI3K/Akt and ERK signaling pathways in non-small cell lung cancer

(2018) Hao Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma

(2018) Lucas de Lima Maia et al.   PLoS One

The hypoxic tumour microenvironment

(2018) Varvara Petrova et al.   Oncogenesis

Hypoxia inducible factors regulate the transcription of the sprouty2 gene and expression of the sprouty2 protein

(2017) Xianlong Gao et al.   PLoS One

A comprehensive review of lysine-specific demethylase 1 and its roles in cancer

(2017) Amir Hosseini et al.   Epigenomics

Hypoxia induces the expression of TET enzymes in HepG2 cells

(2017) Guofu Lin et al.   Oncology Letters

Alpha-Ketoglutarate: Physiological Functions and Applications

(2016) Nan Wu et al.   Biomolecules & Therapeutics

Clinical and biological significance of RAD51 expression in breast cancer: a key DNA damage response protein

(2016) Alaa Tarig Alshareeda et al.   BREAST CANCER RESEARCH AND TREATMENT

Hypoxic reprograming of H3K27me3 and H3K4me3 at the INK4A locus

(2016) Soojeong Chang et al.   FEBS LETTERS

Sirtuins in metabolism, DNA repair and cancer

(2016) Zhen Mei et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Tumour hypoxia causes DNA hypermethylation by reducing TET activity

(2016) Bernard Thienpont et al.   NATURE

Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth

(2016) Michael S. Nakazawa et al.   Nature Communications

Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis

(2016) Yunho Kim et al.   Nature Communications

The histone methyltransferase G9a as a therapeutic target to override gemcitabine resistance in pancreatic cancer

(2016) Mei-Ren Pan et al.   Oncotarget

Hypoxia and metabolic adaptation of cancer cells

(2016) K L Eales et al.   Oncogenesis

Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A Review in the Theme: Cellular Responses to Hypoxia

(2015) Leon Zheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Inhibition of H3K9 methyltransferase G9a induces autophagy and apoptosis in oral squamous cell carcinoma

(2015) Aishu Ren et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

EHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cells

(2015) Jing Cui et al.   Cancer Cell International

Hypoxia Drives Breast Tumor Malignancy through a TET–TNFα–p38–MAPK Signaling Axis

(2015) Min-Zu Wu et al.   CANCER RESEARCH

Hypoxia Induces Production of L-2-Hydroxyglutarate

(2015) Andrew M. Intlekofer et al.   Cell Metabolism

Cell Metabolism Under Microenvironmental Low Oxygen Tension Levels in Stemness, Proliferation and Pluripotency

(2015) M.P. Miguel et al.   CURRENT MOLECULAR MEDICINE

Apoptosis, autophagy, necroptosis, and cancer metastasis

(2015) Zhenyi Su et al.   Molecular Cancer

Progress on hypoxia-inducible factor-3: Its structure, gene regulation and biological function (Review)

(2015) SHENG-LI YANG et al.   Molecular Medicine Reports

Immune evasion in cancer: Mechanistic basis and therapeutic strategies

(2015) Dass S. Vinay et al.   SEMINARS IN CANCER BIOLOGY

Broad targeting of resistance to apoptosis in cancer

(2015) Ramzi M. Mohammad et al.   SEMINARS IN CANCER BIOLOGY

Hypoxia-Inducible Factor-1 in Physiological and Pathophysiological Angiogenesis: Applications and Therapies

(2015) Agnieszka Zimna et al.   Biomed Research International

Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth

(2015) David Vindrieux et al.   Oncotarget

PLA2R1: Expression and function in cancer

(2014) David Bernard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis

(2014) Cathy Ndiaye et al.   LANCET ONCOLOGY

Epigenetic Signature of Chronic Cerebral Hypoperfusion and Beneficial Effects of S-adenosylmethionine in Rats

(2014) Xiangmei Wu et al.   MOLECULAR NEUROBIOLOGY

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

(2014) Xi Chen et al.   NATURE

SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation

(2014) K-S Seo et al.   ONCOGENE

TET1-Mediated Hydroxymethylation Facilitates Hypoxic Gene Induction in Neuroblastoma

(2014) Christopher J. Mariani et al.   Cell Reports

Apoptosis and Molecular Targeting Therapy in Cancer

(2014) Mohamed Hassan et al.   Biomed Research International

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

Transcriptional regulation by hypoxia inducible factors

(2013) Veronica L. Dengler et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Epigenetics in focus: Pathogenesis of myelodysplastic syndromes and the role of hypomethylating agents

(2013) Valeria Santini et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype

(2013) Chris J. Watson et al.   HUMAN MOLECULAR GENETICS

5-Hydroxymethylcytosine as a useful marker to differentiate between malignant melanomas and benign melanocytic nevi

(2013) Ryuhei Uchiyama et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Sensing hypoxia: physiology, genetics and epigenetics

(2013) Nanduri R. Prabhakar   JOURNAL OF PHYSIOLOGY-LONDON

Chromatin modifiers and remodellers: regulators of cellular differentiation

(2013) Taiping Chen et al.   NATURE REVIEWS GENETICS

HIF-1α-induced histone demethylase JMJD2B contributes to the malignant phenotype of colorectal cancer cells via an epigenetic mechanism

(2012) Linna Fu et al.   CARCINOGENESIS

Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma

(2012) Christine Guo Lian et al.   CELL

Prognostic significance and clinical relevance of Sprouty 2 protein expression in human hepatocellular carcinoma

(2012) Kang Song et al.   Hepatobiliary & Pancreatic Diseases International

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

The Curious Chemical Biology of Cytosine: Deamination, Methylation,and Oxidation as Modulators of Genomic Potential

(2011) Christopher S. Nabel et al.   ACS Chemical Biology

Role of the Hypoxia-Related Gene, JMJD1A, in Hepatocellular Carcinoma: Clinical Impact on Recurrence after Hepatic Resection

(2011) Daisaku Yamada et al.   ANNALS OF SURGICAL ONCOLOGY

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

(2011) J. Schodel et al.   BLOOD

The Hypoxia-Associated Factor Switches Cells from HIF-1 - to HIF-2 -Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion

(2011) M. Y. Koh et al.   CANCER RESEARCH

Molecular mechanism of HIF-1-independent VEGF expression in a hepatocellular carcinoma cell line

(2011) Tae-Jin Song   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Sirtuins at a glance

(2011) T. Nakagawa et al.   JOURNAL OF CELL SCIENCE

Hypoxia-Induced Epigenetic Regulation and Silencing of the BRCA1 Promoter

(2011) Y. Lu et al.   MOLECULAR AND CELLULAR BIOLOGY

Hypoxia Induces Genomic DNA Demethylation through the Activation of HIF-1  and Transcriptional Upregulation of MAT2A in Hepatoma Cells

(2011) Q. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

p16Ink4a overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors

(2011) C Romagosa et al.   ONCOGENE

Sprouty 2 Is an Independent Prognostic Factor in Breast Cancer and May Be Useful in Stratifying Patients for Trastuzumab Therapy

(2011) Dana Faratian et al.   PLoS One

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of  -ketoglutarate to citrate to support cell growth and viability

(2011) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

(2011) Y.-F. He et al.   SCIENCE

Evolutionary Conserved Regulation of HIF-1β by NF-κB

(2011) Patrick van Uden et al.   PLoS Genetics

Hypoxia causes epigenetic gene regulation in macrophages by attenuating Jumonji histone demethylase activity

(2010) Michaela Tausendschön et al.   CYTOKINE

Ischemia dysregulates DNA methyltransferases andp16INK4amethylation in human colorectal cancer cells

(2010) Karolina Skowronski et al.   Epigenetics

Epigenetics: The epicenter of the hypoxic response

(2010) Jenny A. Watson et al.   Epigenetics

A 4-Gene Signature Predicts Survival of Patients With Resected Adenocarcinoma of the Esophagus, Junction, and Gastric Cardia

(2010) Christopher J. Peters et al.   GASTROENTEROLOGY

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Charting histone modifications and the functional organization of mammalian genomes

(2010) Vicky W. Zhou et al.   NATURE REVIEWS GENETICS

Mesenchymal stem cells cultured under hypoxia escape from senescence via down-regulation of p16 and extracellular signal regulated kinase

(2009) Yonghui Jin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypoxia-induced autophagy: cell death or cell survival?

(2009) Nathalie M Mazure et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of chemokine gene expression by hypoxia via cooperative activation of NF-κB and histone deacetylase

(2009) Olga Safronova et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

(2009) David R. Mole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of hypoxia in the hallmarks of human cancer

(2009) Kai Ruan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Regulation of the Histone Demethylase JMJD1A by Hypoxia-Inducible Factor 1  Enhances Hypoxic Gene Expression and Tumor Growth

(2009) A. J. Krieg et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of Hypoxia-Inducible Factor 2  Signaling by the Stress-Responsive Deacetylase Sirtuin 1

(2009) E. M. Dioum et al.   SCIENCE

Hypoxia upregulates the histone demethylase JMJD1A via HIF-1

(2008) Sven Wellmann et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α

(2008) Patrick J. Pollard et al.   BIOCHEMICAL JOURNAL

Regulation of hypoxia-inducible factor-1α by NF-κB

(2008) Patrick van Uden et al.   BIOCHEMICAL JOURNAL

Hypoxia-Inducible Factor-2α Transactivates Abcg2 and Promotes Cytoprotection in Cardiac Side Population Cells

(2008) Cindy M. Martin et al.   CIRCULATION RESEARCH

The Interleukin-8 Pathway in Cancer

(2008) D. J.J. Waugh et al.   CLINICAL CANCER RESEARCH

Mechanisms involved in the regulation of histone lysine demethylases

(2008) Fei Lan et al.   CURRENT OPINION IN CELL BIOLOGY

The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF

(2008) Sophie Beyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interplay among BRCA1, SIRT1, and Survivin during BRCA1-Associated Tumorigenesis

(2008) Rui-Hong Wang et al.   MOLECULAR CELL

Hypoxia induces a novel signature of chromatin modifications and global repression of transcription

(2008) Amber Buescher Johnson et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Direct regulation of TWIST by HIF-1α promotes metastasis

(2008) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY