Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A Review in the Theme: Cellular Responses to Hypoxia

Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function

(2015) Caleb J. Kelly et al.   Cell Host & Microbe

Cell Metabolism Under Microenvironmental Low Oxygen Tension Levels in Stemness, Proliferation and Pluripotency

(2015) M.P. Miguel et al.   CURRENT MOLECULAR MEDICINE

HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity

(2015) Bejan J. Saeedi et al.   MOLECULAR BIOLOGY OF THE CELL

Correlation Between Intraluminal Oxygen Gradient and Radial Partitioning of Intestinal Microbiota

(2014) Lindsey Albenberg et al.   GASTROENTEROLOGY

Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB

(2014) Thomas Sonnweber et al.   GUT

Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation

(2014) Eric L. Campbell et al.   IMMUNITY

Loss of Epithelial RelA Results in Deregulated Intestinal Proliferative/Apoptotic Homeostasis and Susceptibility to Inflammation

(2014) K. A. Steinbrecher et al.   JOURNAL OF IMMUNOLOGY

Short-term hypoxic vasodilationin vivois mediated by bioactive nitric oxide metabolites, rather than free nitric oxide derived from haemoglobin-mediated nitrite reduction

(2014) Michele Umbrello et al.   JOURNAL OF PHYSIOLOGY-LONDON

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

(2014) Xi Chen et al.   NATURE

Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases

(2014) Holger K. Eltzschig et al.   NATURE REVIEWS DRUG DISCOVERY

Noninvasive Monitoring of Small Intestinal Oxygen in a Rat Model of Chronic Mesenteric Ischemia

(2013) Elaine M. Fisher et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Monocarboxylate 4 Mediated Butyrate Transport in a Rat Intestinal Epithelial Cell Line

(2013) Ramesh Kekuda et al.   DIGESTIVE DISEASES AND SCIENCES

Human colonic mucus is a reservoir for antimicrobial peptides

(2013) Lena Antoni et al.   Journal of Crohns & Colitis

Fundamental role for HIF-1α in constitutive expression of human β defensin-1

(2013) C J Kelly et al.   Mucosal Immunology

Cell-mediated reduction of human β-defensin 1: a major role for mucosal thioredoxin

(2013) S U Jaeger et al.   Mucosal Immunology

Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis

(2013) L. E. Glover et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD39 and CD73 in immunity and inflammation

(2013) Luca Antonioli et al.   TRENDS IN MOLECULAR MEDICINE

Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia

(2013) Christopher P. Guise et al.   Chinese Journal of Cancer

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Role of oxygen gradients in shaping redox relationships between the human intestine and its microbiota

(2012) Michael Graham Espey   FREE RADICAL BIOLOGY AND MEDICINE

Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning

(2012) K. Sarkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

(2011) J. Schodel et al.   BLOOD

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

(2011) Dallas R. Donohoe et al.   Cell Metabolism

Hypoxia-Inducible Factor-2α Mediates the Adaptive Increase of Intestinal Ferroportin During Iron Deficiency in Mice

(2011) Matthew Taylor et al.   GASTROENTEROLOGY

Electrogenic transport, oxygen consumption, and sensitivity to acute hypoxia of human colonic epithelium

(2011) Graciela E. Carra et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Activation of the prolyl-hydroxylase oxygen-sensing signal cascade leads to AMPK activation in cardiomyocytes

(2011) Hong Yan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Intrarectal administration of oxygenated perfluorodecalin promotes healing of murine colitis by targeting inflammatory hypoxia

(2011) Pieter Hindryckx et al.   LABORATORY INVESTIGATION

Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1

(2011) Bjoern O. Schroeder et al.   NATURE

High Throughput Microplate Respiratory Measurements Using Minimal Quantities Of Isolated Mitochondria

(2011) George W. Rogers et al.   PLoS One

Cytoskeletal Regulation of Epithelial Barrier Function During Inflammation

(2010) Andrei I. Ivanov et al.   AMERICAN JOURNAL OF PATHOLOGY

HIF-2  Enhances  -Catenin/TCF-Driven Transcription by Interacting with  -Catenin

(2010) H. Choi et al.   CANCER RESEARCH

Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex

(2010) Jean-Marc Blouin et al.   INTERNATIONAL JOURNAL OF CANCER

Glucose-Induced Intestinal Vasodilation Via Adenosine A1 Receptors Requires Nitric Oxide but Not K+ATP Channels

(2010) Paul J. Matheson et al.   JOURNAL OF SURGICAL RESEARCH

HIF-1 and HIF-2 transcription factors — Similar but not identical

(2010) Agnieszka Loboda et al.   MOLECULES AND CELLS

Hypoxia: an alarm signal during intestinal inflammation

(2010) Sean P. Colgan et al.   Nature Reviews Gastroenterology & Hepatology

Hypoxia, innate immunity and infection in the lung

(2010) Bettina Schaible et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Significance of nitroimidazole compounds and hypoxia-inducible factor-1 for imaging tumor hypoxia

(2009) Shinae Kizaka-Kondoh et al.   CANCER SCIENCE

Measurements of Subcutaneous Tissue PO2 Reflect Oxygen Metabolism of the Small Intestinal Mucosa during Hemorrhage and Resuscitation

(2009) Å. Mellström et al.   EUROPEAN SURGICAL RESEARCH

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

(2009) David R. Mole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF-2α, but not HIF-1α, promotes iron absorption in mice

(2009) Maria Mastrogiannaki et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF-1α Modulates Energy Metabolism in Cancer Cells by Inducing Over-Expression of Specific Glycolytic Isoforms

(2009) Alvaro Marin-Hernandez et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Human gut microbiome adopts an alternative state following small bowel transplantation

(2009) A. L. Hartman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

Advances in measuring cellular bioenergetics using extracellular flux

(2008) David A. Ferrick et al.   DRUG DISCOVERY TODAY

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Mucins in the mucosal barrier to infection

(2008) S K Linden et al.   Mucosal Immunology

Applications of Nitroimidazole In Vivo Hypoxia Imaging in Ischemic Stroke

(2008) Masashi Takasawa et al.   STROKE