Advances in Targeting the Epidermal Growth Factor Receptor Pathway by Synthetic Products and Its Regulation by Epigenetic Modulators As a Therapy for Glioblastoma

Intra-Tumor DNA Methylation Heterogeneity in Glioblastoma; Implications for DNA Methylation-Based Classification

(2019) Anna Wenger et al.   NEURO-ONCOLOGY

The biological role of peroxiredoxins in innate immune responses of aquatic invertebrates

(2019) Muhammad Nadeem Abbas et al.   FISH & SHELLFISH IMMUNOLOGY

The effect of quercetin on the electrical properties of model lipid membranes and human glioblastoma cells

(2018) Marcin Kruszewski et al.   BIOELECTROCHEMISTRY

Prognostic and predictive value of EGFR and EGFR-ligands in blood of breast cancer patients: a systematic review

(2018) Ina Mathilde Kjaer et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Suppressor of cytokine signaling 6 can enhance epidermal growth factor receptor signaling pathway in Bombyx mori (Dazao)

(2018) Muhammad Nadeem Abbas et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Cancer-testis specific gene OIP5: a downstream gene of E2F1 that promotes tumorigenesis and metastasis in glioblastoma by stabilizing E2F1 signaling

(2018) Jiang He et al.   NEURO-ONCOLOGY

Overexpression of HDAC9 is associated with poor prognosis and tumor progression of breast cancer in Chinese females

(2018) Yixiang huang et al.   OncoTargets and Therapy

Advances in Glioblastoma Multiforme Treatment: New Models for Nanoparticle Therapy

(2018) Elif Ozdemir-Kaynak et al.   Frontiers in Physiology

Inhibition of microRNA-299-5p sensitizes glioblastoma cells to temozolomide via the MAPK/ERK signaling pathway

(2018) Yujiang Peng et al.   BIOSCIENCE REPORTS

Epidermal growth factor receptor: Structure-function informing the design of anticancer therapeutics

(2018) Ruth A. Mitchell et al.   EXPERIMENTAL CELL RESEARCH

Epigenetic modulation of metabolism in glioblastoma

(2018) Zhen Dong et al.   SEMINARS IN CANCER BIOLOGY

Ars2 promotes cell proliferation and tumorigenicity in glioblastoma through regulating miR-6798-3p

(2018) Yibiao Chen et al.   Scientific Reports

MINA53 deficiency leads to glioblastoma cell apoptosis via inducing DNA replication stress and diminishing DNA damage response

(2018) Fan Xuan et al.   Cell Death & Disease

The Role of Mitochondria in Reactive Oxygen Species Generation and Its Implications for Neurodegenerative Diseases

(2018) Saima Kausar et al.   Cells

The EGFR variant III mutant as a target for immunotherapy of glioblastoma multiforme

(2017) Dimitry A. Chistiakov et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Insights From Molecular Profiling of Adult Glioma

(2017) Phedias Diamandis et al.   JOURNAL OF CLINICAL ONCOLOGY

Suppressor of cytokine signaling 2-12 regulates antimicrobial peptides and ecdysteroid signaling pathways in Bombyx mori (Dazao)

(2017) Muhammad Nadeem Abbas et al.   JOURNAL OF INSECT PHYSIOLOGY

Combination of a novel HDAC6 inhibitor ACY-241 and anti-PD-L1 antibody enhances anti-tumor immunity and cytotoxicity in multiple myeloma

(2017) A Ray et al.   LEUKEMIA

Targeting glioma stem cells through combined BMI1 and EZH2 inhibition

(2017) Xun Jin et al.   NATURE MEDICINE

Comparative mitochondrial genome analysis of Daphnis nerii and other lepidopteran insects reveals conserved mitochondrial genome organization and phylogenetic relationships

(2017) Yu Sun et al.   PLoS One

MTSS1 is epigenetically regulated in glioma cells and inhibits glioma cell motility

(2017) Daniel Luxen et al.   Translational Oncology

Synergistic anti-cancer effects of epigenetic drugs on medulloblastoma cells

(2017) Juan Yuan et al.   CELLULAR ONCOLOGY

Epigenetic inactivation of tumour suppressor coding and non-coding genes in human cancer: an update

(2017) Pere Llinàs-Arias et al.   Open Biology

EGFR Amplification and IDH Mutations in Glioblastoma Patients of the Northeast of Morocco

(2017) Nadia Senhaji et al.   Biomed Research International

Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways

(2017) et al.   Cancers

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Molecular pathology of the 10q23.3-26.3 chromosome region in glioblastoma

(2016) E. Alekseeva et al.   ANNALS OF ONCOLOGY

HDAC6 promotes cell proliferation and confers resistance to temozolomide in glioblastoma

(2016) Zhihao Wang et al.   CANCER LETTERS

Determination of EGFR Signaling Output by Opposing Gradients of BMP and JAK/STAT Activity

(2016) Mariana Fregoso Lomas et al.   CURRENT BIOLOGY

Role of mTOR in glioblastoma

(2016) Zekeriya Duzgun et al.   GENE

Molecular and cellular effects of a novel hydroxamate-based HDAC inhibitor – belinostat – in glioblastoma cell lines: a preliminary report

(2016) Magdalena Kusaczuk et al.   INVESTIGATIONAL NEW DRUGS

Superselective intraarterial cerebral infusion of cetuximab after osmotic blood/brain barrier disruption for recurrent malignant glioma: phase I study

(2016) Shamik Chakraborty et al.   JOURNAL OF NEURO-ONCOLOGY

Epidermal growth factor receptor targeting and challenges in glioblastoma

(2016) Amy Haseley Thorne et al.   NEURO-ONCOLOGY

DNA methylation in human epigenomes depends on local topology of CpG sites

(2016) Cecilia Lövkvist et al.   NUCLEIC ACIDS RESEARCH

The RNA methyltransferase Dnmt2 methylates DNA in the structural context of a tRNA

(2016) Steffen Kaiser et al.   RNA Biology

Design, synthesis, and evaluation of cisplatin-containing EGFR targeting bioconjugates as potential therapeutic agents for brain tumors

(2016) Rolf Barth et al.   OncoTargets and Therapy

Anti-Epidermal Growth Factor Receptor Gene Therapy for Glioblastoma

(2016) Martin J. Hicks et al.   PLoS One

Epigenetics and cancer metabolism

(2015) Christelle Johnson et al.   CANCER LETTERS

Ligand-Independent EGFR Signaling

(2015) G. Guo et al.   CANCER RESEARCH

A randomised, open label phase III trial with nimotuzumab, an anti-epidermal growth factor receptor monoclonal antibody in the treatment of newly diagnosed adult glioblastoma

(2015) Manfred Westphal et al.   EUROPEAN JOURNAL OF CANCER

Impact on prognosis of the regional distribution of MGMT methylation with respect to the CpG island methylator phenotype and age in glioma patients

(2015) Pilar Mur et al.   JOURNAL OF NEURO-ONCOLOGY

EGFR Amplified and Overexpressing Glioblastomas and Association With Better Response to Adjuvant Metronomic Temozolomide

(2015) Manuela Cominelli et al.   JNCI-Journal of the National Cancer Institute

Mtss1 is a critical epigenetically regulated tumor suppressor in CML

(2015) M Schemionek et al.   LEUKEMIA

Mutational landscape and clonal architecture in grade II and III gliomas

(2015) Hiromichi Suzuki et al.   NATURE GENETICS

Histone Deacetylase Inhibitors Resensitize EGFR/EGFRvIII-Overexpressing, Erlotinib-Resistant Glioblastoma Cells to Tyrosine Kinase Inhibition

(2015) Katrin Liffers et al.   Targeted Oncology

HDAC9 promotes glioblastoma growth via TAZ-mediated EGFR pathway activation

(2015) Rui Yang et al.   Oncotarget

EGFRvIII does not affect radiosensitivity with or without gefitinib treatment in glioblastoma cells

(2015) Nina Struve et al.   Oncotarget

EGFR Amplified and Overexpressing Glioblastomas and Association With Better Response to Adjuvant Metronomic Temozolomide

(2015) Manuela Cominelli et al.   JNCI-Journal of the National Cancer Institute

Glioblastoma: Molecular Pathways, Stem Cells and Therapeutic Targets

(2015) Meena Jhanwar-Uniyal et al.   Cancers

Epidermal Growth Factor Receptor in Glioma: Signal Transduction, Neuropathology, Imaging, and Radioresistance

(2015) Kimmo J. Hatanpaa et al.   NEOPLASIA

Inhibition of HDAC increases the senescence induced by natural polyphenols in glioma cells

(2014) José E. Vargas et al.   Biochemistry and Cell Biology

Mutational profiling of kinases in glioblastoma

(2014) Fonnet E Bleeker et al.   BMC CANCER

EGFR and EGFRvIII analysis in glioblastoma as therapeutic biomarkers

(2014) Claire Faulkner et al.   BRITISH JOURNAL OF NEUROSURGERY

miR-7 inhibits glioblastoma growth by simultaneously interfering with the PI3K/ATK and Raf/MEK/ERK pathways

(2014) ZHENLIN LIU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

MicroRNA-566 activates EGFR signaling and its inhibition sensitizes glioblastoma cells to nimotuzumab

(2014) Kai-Liang Zhang et al.   Molecular Cancer

MTOR KINASE INHIBITORS AND APOPTOSIS IN GLIOBLASTOMA

(2014) W. A. Weiss et al.   NEURO-ONCOLOGY

NT-39 * GLUTAMINASE-MEDIATED METABOLIC PATHWAY INVOLVES GLIOBLASTOMA RESISTANCE TO mTOR-TARGETED THERAPIES

(2014) K. Tanaka et al.   NEURO-ONCOLOGY

Correlation between EGFR Amplification and the Expression of MicroRNA-200c in Primary Glioblastoma Multiforme

(2014) Eva Serna et al.   PLoS One

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

Most Methylation-Susceptible DNA Sequences in Human Embryonic Stem Cells Undergo a Change in Conformation or Flexibility upon Methylation

(2013) Yasutoshi Shimooka et al.   BIOCHEMISTRY

The discovery of colchicine-SAHA hybrids as a new class of antitumor agents

(2013) Xuan Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Radiotherapy plus nimotuzumab or placebo in the treatment of high grade glioma patients: results from a randomized, double blind trial

(2013) Maria Teresa Solomón et al.   BMC CANCER

EGFR and EGFRvIII in Glioblastoma: Partners in Crime

(2013) Gelareh Zadeh et al.   CANCER CELL

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Epigenetic pathways and glioblastoma treatment

(2013) Jennifer Clarke et al.   Epigenetics

MicroRNAs in islet immunobiology and transplantation

(2013) Antonello Pileggi et al.   IMMUNOLOGIC RESEARCH

HDAC inhibitors induce transcriptional repression of high copy number genes in breast cancer through elongation blockade

(2013) Y J Kim et al.   ONCOGENE

Poly(amido amine) is an ideal carrier of miR-7 for enhancing gene silencing effects on the EGFR pathway in U251 glioma cells

(2013) XIAOZHI LIU et al.   ONCOLOGY REPORTS

Structure and function of epigen, the last EGFR ligand

(2013) Marlon R. Schneider et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells

(2013) M-C Chen et al.   Cell Death & Disease

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

(2012) Dominik Sturm et al.   CANCER CELL

Cancer Genetics and Epigenetics: Two Sides of the Same Coin?

(2012) Jueng Soo You et al.   CANCER CELL

Deregulated Signaling Pathways in Glioblastoma Multiforme: Molecular Mechanisms and Therapeutic Targets

(2012) Hua Mao et al.   CANCER INVESTIGATION

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

Nimotuzumab treatment of malignant gliomas

(2012) Udo Bode et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Histone deacetylase 6 plays a role as a distinct regulator of diverse cellular processes

(2012) Yingxiu Li et al.   FEBS Journal

High level of miR-221/222 confers increased cell invasion and poor prognosis in glioma

(2012) Chunzhi Zhang et al.   Journal of Translational Medicine

The good, the bad and the ugly: Epigenetic mechanisms in glioblastoma

(2012) Helena Carén et al.   MOLECULAR ASPECTS OF MEDICINE

A Systematic Review of MicroRNA in Glioblastoma Multiforme: Micro-modulators in the Mesenchymal Mode of Migration and Invasion

(2012) Heidi G. Møller et al.   MOLECULAR NEUROBIOLOGY

Trials with ‘epigenetic’ drugs: An update

(2012) Angela Nebbioso et al.   Molecular Oncology

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

EGFRvIII gene rearrangement is an early event in glioblastoma tumorigenesis and expression defines a hierarchy modulated by epigenetic mechanisms

(2012) C A Del Vecchio et al.   ONCOGENE

Novel Insights into DNA Methylation Features in Spermatozoa: Stability and Peculiarities

(2012) Csilla Krausz et al.   PLoS One

Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma

(2012) D. Singh et al.   SCIENCE

Differential Sensitivity of Glioma- versus Lung Cancer–Specific EGFR Mutations to EGFR Kinase Inhibitors

(2012) Igor Vivanco et al.   Cancer Discovery

Enhanced effects by 4-phenylbutyrate in combination with RTK inhibitors on proliferation in brain tumor cell models

(2011) Ana-Maria Marino et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

8711 POSTER Addition of Erlotinib Changes Gene Expression in Glioblastoma Cell Lines Treated With Vorinostat

(2011) P. Bezecnv et al.   EUROPEAN JOURNAL OF CANCER

Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas

(2011) Jörg Felsberg et al.   INTERNATIONAL JOURNAL OF CANCER

MTSS1 Overexpression Correlates with Poor Prognosis in Colorectal Cancer

(2011) Ding Wang et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

(2011) Ignacio Varela et al.   NATURE

A phase II trial of erlotinib in patients with recurrent malignant gliomas and nonprogressive glioblastoma multiforme postradiation therapy

(2011) J. J. Raizer et al.   NEURO-ONCOLOGY

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

(2011) Paul B. Chapman et al.   NEW ENGLAND JOURNAL OF MEDICINE

MTSS1, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma

(2011) H Fan et al.   ONCOGENE

Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases

(2011) T Papagiannakopoulos et al.   ONCOGENE

Prediction of Associations between microRNAs and Gene Expression in Glioma Biology

(2011) Stefan Wuchty et al.   PLoS One

Downregulation of metastasis suppressor 1(MTSS1) is associated with nodal metastasis and poor outcome in Chinese patients with gastric cancer

(2010) Ke Liu et al.   BMC CANCER

CUDC-101, a Multitargeted Inhibitor of Histone Deacetylase, Epidermal Growth Factor Receptor, and Human Epidermal Growth Factor Receptor 2, Exerts Potent Anticancer Activity

(2010) Cheng-Jung Lai et al.   CANCER RESEARCH

HDAC5 and HDAC9 in Medulloblastoma: Novel Markers for Risk Stratification and Role in Tumor Cell Growth

(2010) T. Milde et al.   CLINICAL CANCER RESEARCH

Nimotuzumab for pediatric diffuse intrinsic pontine gliomas

(2010) Maura Massimino et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

The Role of HDAC6 in Cancer

(2010) Grace I. Aldana-Masangkay et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Let-7 microRNA inhibits the proliferation of human glioblastoma cells

(2010) Soon-Tae Lee et al.   JOURNAL OF NEURO-ONCOLOGY

A Phase II study of anti–epidermal growth factor receptor radioimmunotherapy in the treatment of glioblastoma multiforme

(2010) Linna Li et al.   JOURNAL OF NEUROSURGERY

Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status

(2010) Xuan Zhou et al.   LABORATORY INVESTIGATION

Safety and efficacy of erlotinib in first-relapse glioblastoma: a phase II open-label study

(2010) W. K. A. Yung et al.   NEURO-ONCOLOGY

ARID1AMutations in Endometriosis-Associated Ovarian Carcinomas

(2010) Kimberly C. Wiegand et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stratified phase II trial of cetuximab in patients with recurrent high-grade glioma

(2009) B. Neyns et al.   ANNALS OF ONCOLOGY

Nimotuzumab, an Antitumor Antibody that Targets the Epidermal Growth Factor Receptor, Blocks Ligand Binding while Permitting the Active Receptor Conformation

(2009) A. Talavera et al.   CANCER RESEARCH

Epidermal Growth Factor Receptor Variant III-Induced Glioma Invasion Is Mediated through Myristoylated Alanine-Rich Protein Kinase C Substrate Overexpression

(2009) J. Micallef et al.   CANCER RESEARCH

Metastasis suppressor 1 (MTSS1) demonstrates prognostic value and anti-metastatic properties in breast cancer

(2009) Christian Parr et al.   EUROPEAN JOURNAL OF CANCER

HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity

(2009) Vivek Sharma et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Randomized Phase II Trial of Erlotinib Versus Temozolomide or Carmustine in Recurrent Glioblastoma: EORTC Brain Tumor Group Study 26034

(2009) Martin J. van den Bent et al.   JOURNAL OF CLINICAL ONCOLOGY

Abrogation of Mitogen-Activated Protein Kinase and Akt Signaling by Vandetanib Synergistically Potentiates Histone Deacetylase Inhibitor-Induced Apoptosis in Human Glioma Cells

(2009) E. P. Jane et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

PI3K Signaling in Glioma-Animal Models and Therapeutic Challenges

(2008) Christine K. Cheng et al.   BRAIN PATHOLOGY

Vegetables and Fruits in Relation to Cancer Risk: Evidence from the Greek EPIC Cohort Study

(2008) V. Benetou et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Multi-targeted prevention and therapy of cancer by proanthocyanidins

(2008) Vijayalakshmi Nandakumar et al.   CANCER LETTERS

microRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and Is Down-regulated in Glioblastoma

(2008) B. Kefas et al.   CANCER RESEARCH

The epidermal growth factor receptor family: Biology driving targeted therapeutics

(2008) M. J. Wieduwilt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibition of Glioblastoma Growth in a Highly Invasive Nude Mouse Model Can Be Achieved by Targeting Epidermal Growth Factor Receptor but not Vascular Endothelial Growth Factor Receptor-2

(2008) T. Martens et al.   CLINICAL CANCER RESEARCH

Ubiquitin Proteasome System Stress Underlies Synergistic Killing of Ovarian Cancer Cells by Bortezomib and a Novel HDAC6 Inhibitor

(2008) M. Bazzaro et al.   CLINICAL CANCER RESEARCH

MicroRNA-128 inhibits glioma cells proliferation by targeting transcription factor E2F3a

(2008) Yu Zhang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Prevalence of copy-number neutral LOH in glioblastomas revealed by genomewide analysis of laser-microdissected tissues

(2008) Daisuke Kuga et al.   NEURO-ONCOLOGY

Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors

(2008) John H. Sampson et al.   NEURO-ONCOLOGY

PTEN signaling in brain: neuropathology and tumorigenesis

(2008) R Endersby et al.   ONCOGENE

Drug discovery approaches targeting the PI3K/Akt pathway in cancer

(2008) C Garcia-Echeverria et al.   ONCOGENE

Hybrid Molecules with a Dual Mode of Action: Dream or Reality?†

(2007) Bernard Meunier   ACCOUNTS OF CHEMICAL RESEARCH