Histone deacetylase 6 plays a role as a distinct regulator of diverse cellular processes

HDAC6 Deacetylates Ku70 and Regulates Ku70-Bax Binding in Neuroblastoma

(2015) Chitra Subramanian et al.   NEOPLASIA

Development and therapeutic impact of HDAC6-selective inhibitors

(2012) Sabrina Dallavalle et al.   BIOCHEMICAL PHARMACOLOGY

HDAC6 controls the kinetics of platelet activation

(2012) K. Sadoul et al.   BLOOD

Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma

(2012) L. Santo et al.   BLOOD

Modulation of Histone Deacetylase 6 (HDAC6) Nuclear Import and Tubulin Deacetylase Activity through Acetylation

(2012) Yuanjing Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Deacetylase 6 (HDAC6) Deacetylates Survivin for Its Nuclear Export in Breast Cancer

(2012) Matthew T. Riolo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HDAC6 Regulates Glucocorticoid Receptor Signaling in Serotonin Pathways with Critical Impact on Stress Resilience

(2012) J. Espallergues et al.   JOURNAL OF NEUROSCIENCE

Loss of Deacetylation Activity of Hdac6 Affects Emotional Behavior in Mice

(2012) Masahide Fukada et al.   PLoS One

The E3-Ubiquitin Ligase TRIM50 Interacts with HDAC6 and p62, and Promotes the Sequestration and Clearance of Ubiquitinated Proteins into the Aggresome

(2012) Carmela Fusco et al.   PLoS One

Roles of GRK2 in Cell Signaling Beyond GPCR Desensitization: GRK2-HDAC6 Interaction Modulates Cell Spreading and Motility

(2012) P. Penela et al.   Science Signaling

Histone Deacetylases 6 and 9 and Sirtuin-1 Control Foxp3+ Regulatory T Cell Function Through Shared and Isoform-Specific Mechanisms

(2012) U. H. Beier et al.   Science Signaling

A Novel Class of Small Molecule Inhibitors of HDAC6

(2011) Elizabeth S. Inks et al.   ACS Chemical Biology

Histone Deacetylase 6 (HDAC6) Is an Essential Modifier of Glucocorticoid-Induced Hepatic Gluconeogenesis

(2011) R. Winkler et al.   DIABETES

Histone acetyltransferases are crucial regulators in NF-κB mediated inflammation

(2011) Massimo Ghizzoni et al.   DRUG DISCOVERY TODAY

A novel GRK2/HDAC6 interaction modulates cell spreading and motility

(2011) Vanesa Lafarga et al.   EMBO JOURNAL

PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-catenin

(2011) Jianzhong Zhu et al.   EMBO JOURNAL

Interplay between histone deacetylases and autophagy - from cancer therapy to neurodegeneration

(2011) Oliver Trüe et al.   IMMUNOLOGY AND CELL BIOLOGY

Regulation of Tat Acetylation and Transactivation Activity by the Microtubule-associated Deacetylase HDAC6

(2011) Lihong Huo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein kinase CK2 regulates the formation and clearance of aggresomes in response to stress

(2011) M. Watabe et al.   JOURNAL OF CELL SCIENCE

HDAC6 regulates aggresome-autophagy degradation pathway of α-synuclein in response to MPP+-induced stress

(2011) Min Su et al.   JOURNAL OF NEUROCHEMISTRY

Sirtuin-1 Targeting Promotes Foxp3+ T-Regulatory Cell Function and Prolongs Allograft Survival

(2011) U. H. Beier et al.   MOLECULAR AND CELLULAR BIOLOGY

Histone Deacetylase 6 and Heat Shock Protein 90 Control the Functions of Foxp3+ T-Regulatory Cells

(2011) E. F. de Zoeten et al.   MOLECULAR AND CELLULAR BIOLOGY

TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6

(2011) Fabienne C Fiesel et al.   Molecular Neurodegeneration

HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease

(2011) Constantin d'Ydewalle et al.   NATURE MEDICINE

The HTLV-1 Tax protein inhibits formation of stress granules by interacting with histone deacetylase 6

(2011) S Legros et al.   ONCOGENE

Hdac6 Knock-Out Increases Tubulin Acetylation but Does Not Modify Disease Progression in the R6/2 Mouse Model of Huntington's Disease

(2011) Anna Bobrowska et al.   PLoS One

Dysferlin Interacts with Histone Deacetylase 6 and Increases alpha-Tubulin Acetylation

(2011) Sabrina Di Fulvio et al.   PLoS One

Quality control autophagy: A joint effort of ubiquitin, protein deacetylase and actin cytoskeleton

(2010) Joo-Yong Lee et al.   Autophagy

Histone/protein deacetylase inhibitors increase suppressive functions of human FOXP3+ Tregs

(2010) Tatiana Akimova et al.   CLINICAL IMMUNOLOGY

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

(2010) Joo-Yong Lee et al.   EMBO JOURNAL

HDAC6 is required for invadopodia activity and invasion by breast tumor cells

(2010) Mercedes Rey et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

TDP-43: A DNA and RNA binding protein with roles in neurodegenerative diseases

(2010) Sadaf T. Warraich et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Acetylation Directs Survivin Nuclear Localization to Repress STAT3 Oncogenic Activity

(2010) Haijuan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Microtubule-associated Histone Deacetylase 6 (HDAC6) Regulates Epidermal Growth Factor Receptor (EGFR) Endocytic Trafficking and Degradation

(2010) Ya-sheng Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of HDAC6 in Cancer

(2010) Grace I. Aldana-Masangkay et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Non-Natural Macrocyclic Inhibitors of Histone Deacetylases: Design, Synthesis, and Activity

(2010) Luciana Auzzas et al.   JOURNAL OF MEDICINAL CHEMISTRY

HDAC6 Regulates Mitochondrial Transport in Hippocampal Neurons

(2010) Sigeng Chen et al.   PLoS One

Functional Analysis of FOXP3

(2009) Jane H. Buckner et al.   Annals of the New York Academy of Sciences

Acetylation of histone deacetylase 6 by p300 attenuates its deacetylase activity

(2009) Younho Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of Lipid Binding Specificities of Dysferlin C2 Domains Reveals Novel Interactions with Phosphoinositides†

(2009) Christian Therrien et al.   BIOCHEMISTRY

The Role of ATF4 Stabilization and Autophagy in Resistance of Breast Cancer Cells Treated with Bortezomib

(2009) M. Milani et al.   CANCER RESEARCH

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

Explorative Study on Isoform-Selective Histone Deacetylase Inhibitors

(2009) Takayoshi Suzuki   CHEMICAL & PHARMACEUTICAL BULLETIN

CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin

(2009) Sara A Wickström et al.   EMBO JOURNAL

Function of Histone Deacetylase 6 as a Cofactor of Nuclear Receptor Coregulator LCoR

(2009) Ana Palijan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma

(2009) Ramin Massoumi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Discovery of Potent and Selective Histone Deacetylase Inhibitors via Focused Combinatorial Libraries of Cyclic α3β-Tetrapeptides

(2009) Christian A. Olsen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

(2009) Kajsa Wing et al.   NATURE IMMUNOLOGY

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors

(2008) David V. Smil et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA

(2008) S. T. Nawrocki et al.   BLOOD

Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules

(2008) S. Patel-Hett et al.   BLOOD

HDAC family: What are the cancer relevant targets?

(2008) Olaf Witt et al.   CANCER LETTERS

The Cytoplasmic Deacetylase HDAC6 Is Required for Efficient Oncogenic Tumorigenesis

(2008) Y.-S. Lee et al.   CANCER RESEARCH

Chemistry, Biology, and QSAR Studies of Substituted Biaryl Hydroxamates and Mercaptoacetamides as HDAC Inhibitors—Nanomolar-Potency Inhibitors of Pancreatic Cancer Cell Growth

(2008) Alan P. Kozikowski et al.   ChemMedChem

Pyridylalanine-Containing Hydroxamic Acids as Selective HDAC6 Inhibitors

(2008) Stefan Schäfer et al.   ChemMedChem

Ubiquitin Proteasome System Stress Underlies Synergistic Killing of Ovarian Cancer Cells by Bortezomib and a Novel HDAC6 Inhibitor

(2008) M. Bazzaro et al.   CLINICAL CANCER RESEARCH

Chemical Origins of Isoform Selectivity in Histone Deacetylase Inhibitors

(2008) Alan Kozikowski et al.   CURRENT PHARMACEUTICAL DESIGN

Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors

(2008) Sabrina Dallavalle et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Abnormal proteins can form aggresome in yeast: aggresome-targeting signals and components of the machinery

(2008) Yan Wang et al.   FASEB JOURNAL

HDAC6 Is Required for Epidermal Growth Factor-induced β-Catenin Nuclear Localization

(2008) Yu Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6

(2008) Alan P. Kozikowski et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Series of Potent and Selective, Triazolylphenyl-Based Histone Deacetylases Inhibitors with Activity against Pancreatic Cancer Cells andPlasmodium falciparum

(2008) Yufeng Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lysine Acetylation Is a Highly Abundant and Evolutionarily Conserved Modification inEscherichia Coli

(2008) Junmei Zhang et al.   MOLECULAR & CELLULAR PROTEOMICS

Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally

(2008) Y. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation

(2008) R. B. Parmigiani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HDAC6: a key regulator of cytoskeleton, cell migration and cell–cell interactions

(2008) Agustín Valenzuela-Fernández et al.   TRENDS IN CELL BIOLOGY