Curcumin and obesity

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction

(2012) Angeliki Chalkiadaki et al.   Cell Metabolism

The Inflammasome Puts Obesity in the Danger Zone

(2012) Rinke Stienstra et al.   Cell Metabolism

Intracellular Signaling Pathways Modulated by Phenolic Compounds: Application for New Anti-Inflammatory Drugs Discovery

(2012) G. Costa et al.   CURRENT MEDICINAL CHEMISTRY

Minireview: Epigenetics of Obesity and Diabetes in Humans

(2012) Howard Slomko et al.   ENDOCRINOLOGY

Prevalence of Obesity and Trends in the Distribution of Body Mass Index Among US Adults, 1999-2010

(2012) Katherine M. Flegal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents

(2012) Sadagopan Magesh et al.   MEDICINAL RESEARCH REVIEWS

Expression of NLRP3 inflammasome and T cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in humans

(2012) Gijs H. Goossens et al.   MOLECULAR IMMUNOLOGY

Pro-Inflammatory wnt5a and Anti-Inflammatory sFRP5 Are Differentially Regulated by Nutritional Factors in Obese Human Subjects

(2012) Dominik M. Schulte et al.   PLoS One

Curcumin Prevents High Fat Diet Induced Insulin Resistance and Obesity via Attenuating Lipogenesis in Liver and Inflammatory Pathway in Adipocytes

(2012) Weijuan Shao et al.   PLoS One

Curcumin Attenuates β-catenin Signaling in Prostate Cancer Cells through Activation of Protein Kinase D1

(2012) Vasudha Sundram et al.   PLoS One

Apelin, a promising target for type 2 diabetes treatment?

(2012) Isabelle Castan-laurell et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The role of WNT10B in physiology and disease

(2011) P. Wend et al.   Acta Physiologica

Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation

(2011) Tin Oo Khor et al.   BIOCHEMICAL PHARMACOLOGY

Adipokines: Biofactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity

(2011) Javier Conde et al.   BIOFACTORS

Dietary factors and low-grade inflammation in relation to overweight and obesity

(2011) Philip C. Calder et al.   BRITISH JOURNAL OF NUTRITION

Nontraditional Risk Factors and Biomarkers for Cardiovascular Disease: Mechanistic, Research, and Clinical Considerations for Youth

(2011) Prabhakaran (Babu) Balagopal et al.   CIRCULATION

Inflammation in osteoarthritis

(2011) Mary B. Goldring et al.   CURRENT OPINION IN RHEUMATOLOGY

Targeting Curcusomes to Inflammatory Dendritic Cells Inhibits NF-κB and Improves Insulin Resistance in Obese Mice

(2011) Suman Kumar Yekollu et al.   DIABETES

Nrf2 Activators as Attractive Therapeutics for Diabetic Nephropathy: FIG. 1.

(2011) Judy B. de Haan   DIABETES

SirT1 Regulates Adipose Tissue Inflammation

(2011) M. P. Gillum et al.   DIABETES

New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases

(2011) Adeeb Shehzad et al.   EUROPEAN JOURNAL OF NUTRITION

Curcumin Attenuates Insulin Resistance in Hepatocytes by Inducing Nrf2 Nuclear Translocation

(2011) Shu-Guang Zhao et al.   HEPATO-GASTROENTEROLOGY

Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): Anti-inflammatory and anti-cancer properties

(2011) Anlys Olivera et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Suppression of fatty acid synthase, differentiation and lipid accumulation in adipocytes by curcumin

(2011) Jiong Zhao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Linking the inflammasome to obesity-related disease

(2011) Tiffany Horng et al.   NATURE MEDICINE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals

(2011) Ling Zhao et al.   NUTRITION REVIEWS

A systematic review on changed biomechanics of lower extremities in obese individuals: a possible role in development of osteoarthritis

(2011) J. Runhaar et al.   Obesity Reviews

Curcumin-induced suppression of adipogenic differentiation is accompanied by activation of Wnt/β-catenin signaling

(2010) Jiyun Ahn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals

(2010) Bharat B. Aggarwal   Annual Review of Nutrition

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Regulation of SIRT1 in cellular functions: Role of polyphenols

(2010) Sangwoon Chung et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Development of curcumin as an epigenetic agent

(2010) Siqing Fu et al.   CANCER

Heart Disease and Stroke Statistics—2011 Update

(2010) Véronique L. Roger et al.   CIRCULATION

Obesity and Inflammation – Targets for OA Therapy

(2010) F. Iannone et al.   CURRENT DRUG TARGETS

Intrinsic Depot-Specific Differences in the Secretome of Adipose Tissue, Preadipocytes, and Adipose Tissue-Derived Microvascular Endothelial Cells

(2010) S. L. Hocking et al.   DIABETES

Long-term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: systematic review

(2010) J J Reilly et al.   INTERNATIONAL JOURNAL OF OBESITY

Deficiency in the Nuclear Factor E2-related Factor-2 Transcription Factor Results in Impaired Adipogenesis and Protects against Diet-induced Obesity

(2010) Jingbo Pi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Activation by Small Molecules

(2010) Han Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Obesity without Established Comorbidities of the Metabolic Syndrome Is Associated with a Proinflammatory and Prothrombotic State, Even before the Onset of Puberty in Children

(2010) Nelly Mauras et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Obesity Increases the Production of Proinflammatory Mediators from Adipose Tissue T Cells and Compromises TCR Repertoire Diversity: Implications for Systemic Inflammation and Insulin Resistance

(2010) H. Yang et al.   JOURNAL OF IMMUNOLOGY

Adipose tissue macrophages: their role in adipose tissue remodeling

(2010) Takayoshi Suganami et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Curcumin inhibits adipocyte differentiation through modulation of mitotic clonal expansion

(2010) Choon Young Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Tumor Necrosis Factor α and Regulation of Adipose Tissue

(2010) Erik Arner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Body-Mass Index and Mortality among 1.46 Million White Adults

(2010) Amy Berrington de Gonzalez et al.   NEW ENGLAND JOURNAL OF MEDICINE

Curcumin improves insulin resistance in skeletal muscle of rats

(2010) L.-X. Na et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Curcumin and obesity: evidence and mechanisms

(2010) Lini Alappat et al.   NUTRITION REVIEWS

Obesity, weight loss and conditional cardiovascular risk factors

(2010) T. Tzotzas et al.   Obesity Reviews

The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review

(2010) S. Clockaerts et al.   OSTEOARTHRITIS AND CARTILAGE

Sirtuins regulate key aspects of lipid metabolism

(2009) David J. Lomb et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis

(2009) Daphne P Guh et al.   BMC PUBLIC HEALTH

Correlation of synovial fluid leptin concentrations with the severity of osteoarthritis

(2009) Jung Hoei Ku et al.   CLINICAL RHEUMATOLOGY

Diabesity: therapeutic options

(2009) S. Colagiuri   DIABETES OBESITY & METABOLISM

Curcumin Inhibits Adipogenesis in 3T3-L1 Adipocytes and Angiogenesis and Obesity in C57/BL Mice

(2009) Asma Ejaz et al.   JOURNAL OF NUTRITION

Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies

(2009) Prospective Studies Collaboration   LANCET

Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome

(2009) E. Maury et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Dietary curcumin supplementation counteracts reduction in levels of molecules involved in energy homeostasis after brain trauma

(2009) S. Sharma et al.   NEUROSCIENCE

Subcutaneous and visceral adipose tissue: structural and functional differences

(2009) M. Mohsen Ibrahim   Obesity Reviews

Biological actions of curcumin on articular chondrocytes

(2009) Y. Henrotin et al.   OSTEOARTHRITIS AND CARTILAGE

Evaluation of Nod-Like Receptor (NLR) Effector Domain Interactions

(2009) Roland N. Wagner et al.   PLoS One

NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease

(2008) Grace Chen et al.   Annual Review of Pathology-Mechanisms of Disease

Dietary Curcumin Significantly Improves Obesity-Associated Inflammation and Diabetes in Mouse Models of Diabesity

(2008) Stuart P. Weisberg et al.   ENDOCRINOLOGY

Wnt signaling controls the fate of mesenchymal stem cells

(2008) Ling Ling et al.   GENE

Curcumin Exerts Antidifferentiation Effect through AMPKα-PPAR-γ in 3T3-L1 Adipocytes and Antiproliferatory Effect through AMPKα-COX-2 in Cancer Cells

(2008) Yun K. Lee et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Adipose Inflammation, Insulin Resistance, and Cardiovascular Disease

(2008) Arti Shah et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Adipogenesis and WNT signalling

(2008) Constantinos Christodoulides et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM