Licochalcone A Upregulates Nrf2 Antioxidant Pathway and Thereby Alleviates Acetaminophen-Induced Hepatotoxicity

Protective role of p53 in acetaminophen hepatotoxicity

(2017) Yazhen Huo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatic hypoxia-inducible factors inhibit PPARα expression to exacerbate acetaminophen induced oxidative stress and hepatotoxicity

(2017) Dawei Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide ( t -BHP)-induced mitochondrial dysfunction and cell death

(2017) Hongming Lv et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pinocembrin Suppresses H2O2-Induced Mitochondrial Dysfunction by a Mechanism Dependent on the Nrf2/HO-1 Axis in SH-SY5Y Cells

(2017) Marcos Roberto de Oliveira et al.   MOLECULAR NEUROBIOLOGY

Hepatoprotective Effect of Polyphenol-Enriched Fraction from Folium Microcos on Oxidative Stress and Apoptosis in Acetaminophen-Induced Liver Injury in Mice

(2017) Hongtan Wu et al.   Oxidative Medicine and Cellular Longevity

Frequency and prognosis of acute pancreatitis associated with fulminant or non-fulminant acute hepatitis A: A systematic review

(2017) Samir Haffar et al.   PANCREATOLOGY

Effects of rosmarinic acid on acetaminophen-induced hepatotoxicity in male Wistar rats

(2017) Parisa Hasanein et al.   PHARMACEUTICAL BIOLOGY

Schisandrol B protects against acetaminophen-induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway

(2016) Yi-ming Jiang et al.   ACTA PHARMACOLOGICA SINICA

Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity

(2016) Kuo Du et al.   ARCHIVES OF TOXICOLOGY

Withaferin A induces Nrf2-dependent protection against liver injury: Role of Keap1-independent mechanisms

(2016) Dushani L. Palliyaguru et al.   FREE RADICAL BIOLOGY AND MEDICINE

Paeoniflorin protects Schwann cells against high glucose induced oxidative injury by activating Nrf2/ARE pathway and inhibiting apoptosis

(2016) Xinwei Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Cytochrome c as a Potentially Clinical Useful Marker of Mitochondrial and Cellular Damage

(2016) Theodoros Eleftheriadis et al.   Frontiers in Immunology

Withaferin-A Reduces Acetaminophen-Induced Liver Injury in Mice

(2015) Ravirajsinh N. Jadeja et al.   BIOCHEMICAL PHARMACOLOGY

Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients

(2015) Hartmut Jaeschke   DIGESTIVE DISEASES

Glycycoumarin ameliorates alcohol-induced hepatotoxicity via activation of Nrf2 and autophagy

(2015) Xinhua Song et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acute liver failure: A curable disease by 2024?

(2015) William Bernal et al.   JOURNAL OF HEPATOLOGY

Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells

(2015) Gopinath Kulasekaran et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Lico A Enhances Nrf2-Mediated Defense Mechanisms againstt-BHP-Induced Oxidative Stress and Cell Death via Akt and ERK Activation in RAW 264.7 Cells

(2015) Hongming Lv et al.   Oxidative Medicine and Cellular Longevity

Effects of the Total Saponins from Rosa laevigata Michx Fruit against Acetaminophen-Induced Liver Damage in Mice via Induction of Autophagy and Suppression of Inflammation and Apoptosis

(2014) Deshi Dong et al.   MOLECULES

Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases

(2013) Hemant Kumar et al.   NATURAL PRODUCT REPORTS

Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

(2013) Mitchell R. McGill et al.   PHARMACEUTICAL RESEARCH

Steroid Receptor Coactivator-interacting Protein (SIP) Inhibits Caspase-independent Apoptosis by Preventing Apoptosis-inducing Factor (AIF) from Being Released from Mitochondria

(2012) Dandan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

Lupeol prevents acetaminophen-induced in vivo hepatotoxicity by altering the Bax/Bcl-2 and oxidative stress-mediated mitochondrial signaling cascade

(2012) Archana Kumari et al.   LIFE SCIENCES

Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: Modulation by the Nrf2/Trx axis

(2010) Mireia Niso-Santano et al.   FREE RADICAL BIOLOGY AND MEDICINE

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

(2010) Deepti Malhotra et al.   NUCLEIC ACIDS RESEARCH

c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity

(2010) Chieko Saito et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Resolution of inflammation-related apoptotic processes by the synthetic tellurium compound, AS101 following liver injury

(2009) Miri Brodsky et al.   JOURNAL OF HEPATOLOGY

Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

(2008) Naoko Hanawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Licochalcone A isolated from licorice suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice

(2008) Hyuck-Se Kwon et al.   JOURNAL OF MOLECULAR MEDICINE-JMM