Brain Innate Immune Response in Diet-Induced Obesity as a Paradigm for Metabolic Influence on Inflammatory Signaling

Cell culture models of fatty acid overload: Problems and solutions

(2018) Nour Alsabeeh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Fetal monocytes and the origins of tissue-resident macrophages

(2018) Guillaume Hoeffel et al.   CELLULAR IMMUNOLOGY

Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses

(2018) Lily Boutens et al.   DIABETOLOGIA

Cell and molecular mechanisms behind diet-induced hypothalamic inflammation and obesity

(2018) Yenniffer Ávalos et al.   JOURNAL OF NEUROENDOCRINOLOGY

A Combination of Ontogeny and CNS Environment Establishes Microglial Identity

(2018) F. Chris Bennett et al.   NEURON

Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids

(2018) Marcelo Rogero et al.   Nutrients

A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation

(2018) Niamh C. Williams et al.   Frontiers in Immunology

Deficiency of leptin receptor in myeloid cells disrupts hypothalamic metabolic circuits and causes body weight increase

(2018) Yuanqing Gao et al.   Molecular Metabolism

Conditional microglial depletion in rats leads to reversible anorexia and weight loss by disrupting gustatory circuitry

(2018) Simone N. De Luca et al.   BRAIN BEHAVIOR AND IMMUNITY

Hypothalamic Inflammation at a Crossroad of Somatic Diseases

(2018) Boris Mravec et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Hypothalamic Macrophage Inducible Nitric Oxide Synthase Mediates Obesity-Associated Hypothalamic Inflammation

(2018) Chan Hee Lee et al.   Cell Reports

Dietary Fatty Acid Composition Modulates Obesity and Interacts with Obesity-Related Genes

(2017) Shatha S. Hammad et al.   LIPIDS

Identification of a fatty acid binding protein4-UCP2 axis regulating microglial mediated neuroinflammation

(2017) Cayla M. Duffy et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

An environment-dependent transcriptional network specifies human microglia identity

(2017) David Gosselin et al.   SCIENCE

Macrophage Immunometabolism: Where Are We (Going)?

(2017) Jan Van den Bossche et al.   TRENDS IN IMMUNOLOGY

TNFα drives mitochondrial stress in POMC neurons in obesity

(2017) Chun-Xia Yi et al.   Nature Communications

Quercetin Protects Obesity-Induced Hypothalamic Inflammation by Reducing Microglia-Mediated Inflammatory Responses via HO-1 Induction

(2017) Jihyeon Yang et al.   Nutrients

Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity

(2017) Brittney R. Coats et al.   Cell Reports

Lipoprotein Lipase Maintains Microglial Innate Immunity in Obesity

(2017) Yuanqing Gao et al.   Cell Reports

An updated assessment of microglia depletion: current concepts and future directions

(2017) Jinming Han et al.   Molecular Brain

Short-term exposure to a diet high in fat and sugar, or liquid sugar, selectively impairs hippocampal-dependent memory, with differential impacts on inflammation

(2016) J.E. Beilharz et al.   BEHAVIOURAL BRAIN RESEARCH

Macrophage fatty acid oxidation and its roles in macrophage polarization and fatty acid-induced inflammation

(2016) Dmitry Namgaladze et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Inhibiting Microglia Expansion Prevents Diet-Induced Hypothalamic and Peripheral Inflammation

(2016) Caroline André et al.   DIABETES

Fatty acids and chronic low grade inflammation associated with obesity and the metabolic syndrome

(2016) Aoife A. Cooke et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

(2016) Deepika Sharma et al.   JOURNAL OF CELL BIOLOGY

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

(2016) Amanda Littlewood-Evans et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High-fat diet feeding differentially affects the development of inflammation in the central nervous system

(2016) Owein Guillemot-Legris et al.   Journal of Neuroinflammation

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells

(2016) Megan M. Robblee et al.   Cell Reports

Hypothalamic Inflammation in the Control of Metabolic Function

(2015) Martin Valdearcos et al.   Annual Review of Physiology

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

A sexually dimorphic hypothalamic response to chronic high-fat diet consumption

(2015) E Morselli et al.   INTERNATIONAL JOURNAL OF OBESITY

Radiologic evidence that hypothalamic gliosis is associated with obesity and insulin resistance in humans

(2015) Ellen A. Schur et al.   Obesity

Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

(2014) Mario Kratz et al.   Cell Metabolism

Inhibition of macrophage fatty acid β-oxidation exacerbates palmitate-induced inflammatory and endoplasmic reticulum stress responses

(2014) Dmitry Namgaladze et al.   DIABETOLOGIA

Hypothalamic Gliosis Associated With High-Fat Diet Feeding Is Reversible in Mice: A Combined Immunohistochemical and Magnetic Resonance Imaging Study

(2014) Kathryn E. Berkseth et al.   ENDOCRINOLOGY

Potential role of omega-3-derived resolution mediators in metabolic inflammation

(2014) Phillip J White et al.   IMMUNOLOGY AND CELL BIOLOGY

Tanycytes: A Gateway to the Metabolic Hypothalamus

(2014) F. Langlet   JOURNAL OF NEUROENDOCRINOLOGY

Glucose pathways adaptation supports acquisition of activated microglia phenotype

(2014) J. Gimeno-Bayón et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function

(2014) Martin Valdearcos et al.   Cell Reports

Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75/mortalin

(2013) Ludmila A. Voloboueva et al.   FEBS LETTERS

Hormones and diet, but not body weight, control hypothalamic microglial activity

(2013) Yuanqing Gao et al.   GLIA

Exposure to the Saturated Free Fatty Acid Palmitate Alters BV-2 Microglia Inflammatory Response

(2013) Linda M. Tracy et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

(2012) Shurong Huang et al.   JOURNAL OF LIPID RESEARCH

Blood-Borne Metabolic Factors in Obesity Exacerbate Injury-Induced Gliosis

(2012) Hung Hsuchou et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

GLP-1 secretion by microglial cells and decreased CNS expression in obesity

(2012) Camilla Kappe et al.   Journal of Neuroinflammation

Saturated fatty acids activate microglia via Toll-like receptor 4/NF-κB signalling

(2011) Zhen Wang et al.   BRITISH JOURNAL OF NUTRITION

Altered hypothalamic function in diet-induced obesity

(2011) L A Velloso et al.   INTERNATIONAL JOURNAL OF OBESITY

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

Inflammatory lipid mediators in adipocyte function and obesity

(2010) Abishek Iyer et al.   Nature Reviews Endocrinology

Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity

(2010) T. L. Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis

(2009) Daphne P Guh et al.   BMC PUBLIC HEALTH

Hypothalamic inflammation and energy homeostasis: Resolving the paradox

(2009) Joshua P. Thaler et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

(2008) Kelly A. Posey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Obesity and vulnerability of the CNS

(2008) Annadora J. Bruce-Keller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Obesity and Free Fatty Acids

(2008) Guenther Boden   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA