Lysosomal Iron, Iron Chelation, and Cell Death

How apoptotic cells aid in the removal of their own cold dead bodies

(2012) G Wickman et al.   CELL DEATH AND DIFFERENTIATION

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Structural Insights into the Ferroxidase Site of Ferritins from Higher Eukaryotes

(2012) Ivano Bertini et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes

(2011) D. B. Lovejoy et al.   CANCER RESEARCH

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Cell death by autophagy: facts and apparent artefacts

(2011) D Denton et al.   CELL DEATH AND DIFFERENTIATION

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Microautophagy: lesser-known self-eating

(2011) Wen-wen Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Medicinal Chemistry of Novel Iron Chelators for the Treatment of Cancer

(2011) Zaklina Kovacevic et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Cell sensitivity to oxidative stress is influenced by ferritin autophagy

(2011) Tino Kurz et al.   FREE RADICAL BIOLOGY AND MEDICINE

The role of lysosomes in iron metabolism and recycling

(2011) Tino Kurz et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Autophagy and disease: always two sides to a problem

(2011) Sunandini Sridhar et al.   JOURNAL OF PATHOLOGY

Distinct Mechanisms of Ferritin Delivery to Lysosomes in Iron-Depleted and Iron-Replete Cells

(2011) T. Asano et al.   MOLECULAR AND CELLULAR BIOLOGY

Canonical and non-canonical autophagy: variations on a common theme of self-eating?

(2011) Patrice Codogno et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

Lysosomal Proteolysis Is the Primary Degradation Pathway for Cytosolic Ferritin and Cytosolic Ferritin Degradation Is Necessary for Iron Exit

(2010) Yinghui Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Chelation of lysosomal iron protects against ionizing radiation

(2010) Carsten Berndt et al.   BIOCHEMICAL JOURNAL

Artesunate Activates Mitochondrial Apoptosis in Breast Cancer Cells via Iron-catalyzed Lysosomal Reactive Oxygen Species Production

(2010) Anne Hamacher-Brady et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disorders of iron metabolism. Part 1: molecular basis of iron homoeostasis

(2010) M. Munoz et al.   JOURNAL OF CLINICAL PATHOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol

(2010) D. R. Richardson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy and Tumorigenesis

(2010) Srirupa Roy et al.   Seminars in Immunopathology

Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial–Lysosomal Axis Theory of Aging

(2009) Alexei Terman et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial calpain system: An overview

(2009) Pulak Kar et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Autophagy of HSP70 and chelation of lysosomal iron in a non-redox-active form

(2009) Tino Kurz et al.   Autophagy

Specific iron chelators determine the route of ferritin degradation

(2009) I. De Domenico et al.   BLOOD

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Electron microscopy and cytochemistry analysis of the endocytic pathway of pathogenic protozoa

(2009) Wanderley de Souza et al.   PROGRESS IN HISTOCHEMISTRY AND CYTOCHEMISTRY

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents

(2008) D.R. Richardson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Lysosomal involvement in cell death and cancer

(2008) Thomas Kirkegaard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

(2008) Anshul Gupte et al.   CANCER TREATMENT REVIEWS

Control of autophagy by oncogenes and tumor suppressor genes

(2008) M C Maiuri et al.   CELL DEATH AND DIFFERENTIATION

Autophagy–physiology and pathophysiology

(2008) Yasuo Uchiyama et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

(2008) Xian-Ping Dong et al.   NATURE