Therapeutic targets for altering mitochondrial dysfunction associated with diabetic retinopathy

Sirt1: A Guardian of the Development of Diabetic Retinopathy

(2018) Manish Mishra et al.   DIABETES

Epigenetic regulation of redox signaling in diabetic retinopathy: Role of Nrf2

(2017) Renu A. Kowluru et al.   FREE RADICAL BIOLOGY AND MEDICINE

Treatment of cardiovascular pathology with epigenetically active agents: Focus on natural and synthetic inhibitors of DNA methylation and histone deacetylation

(2017) Dimitry A. Chistiakov et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Functional changes in the neural retina occur in the absence of mitochondrial dysfunction in a rodent model of diabetic retinopathy

(2017) Dustin R. Masser et al.   JOURNAL OF NEUROCHEMISTRY

Diabetic microangiopathy: Pathogenetic insights and novel therapeutic approaches

(2017) Rosalinda Madonna et al.   VASCULAR PHARMACOLOGY

TXNIP regulates mitophagy in retinal Müller cells under high-glucose conditions: implications for diabetic retinopathy

(2017) Takhellambam Swornalata Devi et al.   Cell Death & Disease

Interplay of mitochondrial metabolism and microRNAs

(2016) Julian Geiger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nrf2 protects mitochondrial decay by oxidative stress

(2016) Joshua Strom et al.   FASEB JOURNAL

Nrf2 promotes reparative angiogenesis through regulation of NADPH oxidase-2 in oxygen-induced retinopathy

(2016) Yanhong Wei et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dynamic DNA methylation of matrix metalloproteinase-9 in the development of diabetic retinopathy

(2016) Renu A Kowluru et al.   LABORATORY INVESTIGATION

Hyperlipidemia and the development of diabetic retinopathy: Comparison between type 1 and type 2 animal models

(2016) Renu A. Kowluru et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Targeting the cancer epigenome for therapy

(2016) Peter A. Jones et al.   NATURE REVIEWS GENETICS

Blue Light Action on Mitochondria Leads to Cell Death by Necroptosis

(2016) Susana del Olmo-Aguado et al.   NEUROCHEMICAL RESEARCH

Aldose reductase, ocular diabetic complications and the development of topical Kinostat ®

(2016) Peter F. Kador et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Role of Acid Sphingomyelinase in Shifting the Balance Between Proinflammatory and Reparative Bone Marrow Cells in Diabetic Retinopathy

(2016) Harshini Chakravarthy et al.   STEM CELLS

Arginase 2 promotes neurovascular degeneration during ischemia/reperfusion injury

(2016) Esraa Shosha et al.   Cell Death & Disease

Oxidative stress, mitochondrial damage and diabetic retinopathy

(2015) Renu A. Kowluru et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy

(2015) Elisabet Agardh et al.   BMC Medicine

The Diabetes Visual Function Supplement Study (DiVFuSS)

(2015) A Paul Chous et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

DNA Methyltransferases Inhibitors from Natural Sources

(2015) Clemens Zwergel et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The emerging role of Nrf2 in mitochondrial function

(2015) Albena T. Dinkova-Kostova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Circulating levels of reactive oxygen species in patients with nonproliferative diabetic retinopathy and the influence of antioxidant supplementation: 6-month follow-up

(2015) Carmela Carnevale et al.   INDIAN JOURNAL OF OPHTHALMOLOGY

Nrf2 activators modulate oxidative stress responses and bioenergetic profiles of human retinal epithelial cells cultured in normal or high glucose conditions

(2015) Roberta Foresti et al.   PHARMACOLOGICAL RESEARCH

Oxidative stress and epigenetic modifications in the pathogenesis of diabetic retinopathy

(2015) Renu A. Kowluru et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The effect of ubiquinone and combined antioxidant therapy on oxidative stress markers in non-proliferative diabetic retinopathy: A phase IIa, randomized, double-blind, and placebo-controlled study

(2015) Adolfo Daniel Rodríguez-Carrizalez et al.   REDOX REPORT

TIAM1–RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy

(2014) Renu A. Kowluru et al.   DIABETOLOGIA

The role of epigenetics in age-related macular degeneration

(2014) M Gemenetzi et al.   EYE

Epigenetic modifications of Nrf2-mediated glutamate–cysteine ligase: implications for the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued progression

(2014) Manish Mishra et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glutathione and cellular redox control in epigenetic regulation

(2014) José Luis García-Giménez et al.   FREE RADICAL BIOLOGY AND MEDICINE

Retinal Mitochondrial DNA Mismatch Repair in the Development of Diabetic Retinopathy, and Its Continued Progression After Termination of Hyperglycemia

(2014) M. Mishra et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Transcription Factors NRF2 and NF-κB Are Coordinated Effectors of the Rho Family, GTP-binding Protein RAC1 during Inflammation

(2014) Antonio Cuadrado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Is there new hope for therapeutic matrix metalloproteinase inhibition?

(2014) Roosmarijn E. Vandenbroucke et al.   NATURE REVIEWS DRUG DISCOVERY

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of microRNAs in the modulation of diabetic retinopathy

(2014) Rodolfo Mastropasqua et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Accelerometer-Assessed Physical Activity and Diabetic Retinopathy in the United States

(2014) Paul D. Loprinzi et al.   JAMA Ophthalmology

Rationale and design of the EMBRACE STEMI Study: A phase 2a, randomized, double-blind, placebo-controlled trial to evaluate the safety, tolerability and efficacy of intravenous Bendavia on reperfusion injury in patients treated with standard therapy including primary percutaneous coronary intervention and stenting for ST-segment elevation myocardial infarction

(2013) Anjan K. Chakrabarti et al.   AMERICAN HEART JOURNAL

Ten-eleven translocation (Tet) and thymine DNA glycosylase (TDG), components of the demethylation pathway, are direct targets of miRNA-29a

(2013) Pei Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endothelial dysfunction — A major mediator of diabetic vascular disease

(2013) Cristina M. Sena et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Regulation of Matrix Metalloproteinase-9 by Epigenetic Modifications and the Development of Diabetic Retinopathy

(2013) Q. Zhong et al.   DIABETES

Diabetic Retinopathy and Other Ocular Findings in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study

(2013) Lloyd Paul Aiello et al.   DIABETES CARE

Correlation Between Plasma Pentosidine Concentrations and Retinal Hemodynamics in Patients With Type 2 Diabetes

(2012) Eiichi Sato et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Damaged Mitochondrial DNA Replication System and the Development of Diabetic Retinopathy

(2012) Shikha Tewari et al.   ANTIOXIDANTS & REDOX SIGNALING

Global Prevalence and Major Risk Factors of Diabetic Retinopathy

(2012) J. W. Y. Yau et al.   DIABETES CARE

TXNIP Links Innate Host Defense Mechanisms to Oxidative Stress and Inflammation in Retinal Muller Glia under Chronic Hyperglycemia: Implications for Diabetic Retinopathy

(2012) Takhellambam S. Devi et al.   Experimental Diabetes Research

A compensatory mechanism protects retinal mitochondria from initial insult in diabetic retinopathy

(2012) Julia M. Santos et al.   FREE RADICAL BIOLOGY AND MEDICINE

The 4a/4a genotype of the VNTR polymorphism for endothelial nitric oxide synthase (eNOS) gene predicts risk for proliferative diabetic retinopathy in Slovenian patients (Caucasians) with type 2 diabetes mellitus

(2012) Ines Cilenšek et al.   MOLECULAR BIOLOGY REPORTS

Minimizing the damage: repair pathways keep mitochondrial DNA intact

(2012) Lawrence Kazak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Diabetic Retinopathy

(2012) David A. Antonetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

(2011) David C. Chan   Annual Review of Genetics

Nucleus-encoded regulators of mitochondrial function: Integration of respiratory chain expression, nutrient sensing and metabolic stress

(2011) Richard C. Scarpulla   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The Unconventional Role of Acid Sphingomyelinase in Regulation of Retinal Microangiopathy in Diabetic Human and Animal Models

(2011) M. Opreanu et al.   DIABETES

Epigenetic Changes in Mitochondrial Superoxide Dismutase in the Retina and the Development of Diabetic Retinopathy

(2011) Q. Zhong et al.   DIABETES

Abrogation of MMP-9 Gene Protects Against the Development of Retinopathy in Diabetic Mice by Preventing Mitochondrial Damage

(2011) Renu A. Kowluru et al.   DIABETES

New nucleoside analogs for patients with hematological malignancies

(2011) Tadeusz Robak   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Mitochondrial biogenesis and the development of diabetic retinopathy

(2011) Julia M. Santos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

EFFECT OF RUBOXISTAURIN (RBX) ON VISUAL ACUITY DECLINE OVER A 6-YEAR PERIOD WITH CESSATION AND REINSTITUTION OF THERAPY

(2011) Matthew J Sheetz et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Mitochondrial mitophagic mechanisms of myocardial matrix metabolism and remodelling

(2011) Thomas P. Vacek et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Role of Mitochondrial DNA Damage in the Development of Diabetic Retinopathy, and the Metabolic Memory Phenomenon Associated with Its Progression

(2010) Sally A. Madsen–Bouterse et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations

(2010) Hsiuchen Chen et al.   CELL

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Matrix metalloproteinase-2 in the development of diabetic retinopathy and mitochondrial dysfunction

(2010) Ghulam Mohammad et al.   LABORATORY INVESTIGATION

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways

(2009) Jenelle M. Timmins et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy

(2009) Pedro Geraldes et al.   NATURE MEDICINE

Cristae formation—linking ultrastructure and function of mitochondria

(2008) Michael Zick et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis and Function

(2008) Richard C. Scarpulla   PHYSIOLOGICAL REVIEWS