Multifunctional TRPV1 Ion Channels in Physiology and Pathology with Focus on the Brain, Vasculature, and Some Visceral Systems

TRPV1 mediates the anticonvulsant effects of acetaminophen in mice

(2018) Katsuya Suemaru et al.   EPILEPSY RESEARCH

Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis

(2018) Jianmin Chen et al.   FASEB JOURNAL

Expression of TRPV1 channels by Cajal-Retzius cells and layer-specific modulation of synaptic transmission by capsaicin in the mouse hippocampus

(2018) Max Anstötz et al.   JOURNAL OF PHYSIOLOGY-LONDON

TRPV1 alterations in urinary bladder dysfunction in a rat model of STZ-induced diabetes

(2018) Bizhan R. Sharopov et al.   LIFE SCIENCES

Peripheral GABA A receptor-mediated signaling facilitates persistent inflammatory hypersensitivity

(2018) Pa Reum Lee et al.   NEUROPHARMACOLOGY

Psychophysical and vasomotor evidence for interdependency of TRPA1 and TRPV1 nociceptive responses in human skin

(2018) Thomas Arendt Nielsen et al.   PAIN

TRPV1 Blocking Alleviates Airway Inflammation and Remodeling in a Chronic Asthma Murine Model

(2018) Joon Young Choi et al.   Allergy Asthma & Immunology Research

TRPV1 enhances the afferent response to P2X receptor activation in the mouse urinary bladder

(2018) Luke Grundy et al.   Scientific Reports

Blockade of TRPV1 Inhibits Methamphetamine-induced Rewarding Effects

(2018) Yu-Hua Tian et al.   Scientific Reports

A TRP channel trio mediates acute noxious heat sensing

(2018) Ine Vandewauw et al.   NATURE

The Regulation of Pulmonary Vascular Tone by Neuropeptides and the Implications for Pulmonary Hypertension

(2018) Charmaine C. W. Lo et al.   Frontiers in Physiology

Involvement of TRPV1 Channels in Energy Homeostasis

(2018) Stewart Christie et al.   Frontiers in Endocrinology

Diosmetin as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive activity in mice

(2018) Gabriela Adamante et al.   LIFE SCIENCES

Immune aspects of the bi-directional neuroimmune facilitator TRPV1

(2018) Yan-Ruide Li et al.   MOLECULAR BIOLOGY REPORTS

TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro

(2018) Hugo Balleza-Tapia et al.   eLife

Oxytocin, GABA, and TRPV1, the Analgesic Triad?

(2018) Abimael Gonzalez-Hernandez et al.   Frontiers in Molecular Neuroscience

TRPV1 activation counters diet-induced obesity through sirtuin-1 activation and PRDM-16 deacetylation in brown adipose tissue

(2017) P Baskaran et al.   INTERNATIONAL JOURNAL OF OBESITY

Local GABAergic signaling within sensory ganglia controls peripheral nociceptive transmission

(2017) Xiaona Du et al.   JOURNAL OF CLINICAL INVESTIGATION

N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1

(2017) Samira K. Lawton et al.   JOURNAL OF IMMUNOLOGY

4,5-Di-O-Caffeoylquinic Acid from Ligularia fischeri Suppresses Inflammatory Responses Through TRPV1 Activation

(2017) Yiseul Kim et al.   PHYTOTHERAPY RESEARCH

Calcium signalling induced by in vitro exposure to silicium dioxide nanoparticles in rat pulmonary artery smooth muscle cells

(2017) Virginie Dubes et al.   TOXICOLOGY

TRPV1: A Potential Therapeutic Target in Type 2 Diabetes and Comorbidities?

(2017) Dorte X. Gram et al.   TRENDS IN MOLECULAR MEDICINE

Sensory TRP channels contribute differentially to skin inflammation and persistent itch

(2017) Jing Feng et al.   Nature Communications

Impairment of opiate-mediated behaviors by the selective TRPV1 antagonist SB366791

(2016) Shi-Xun Ma et al.   ADDICTION BIOLOGY

Histamine Receptor H1–Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome

(2016) Mira M. Wouters et al.   GASTROENTEROLOGY

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

(2016) Yuan Gao et al.   NATURE

The gastrointestinal tract - a central organ of cannabinoid signaling in health and disease

(2016) C. Hasenoehrl et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Species-Related Differences in the Properties of TRPC4 Channels in Intestinal Myocytes of Rodents

(2016) D. O. Dryn et al.   NEUROPHYSIOLOGY

TRP functions in the broncho-pulmonary system

(2016) Francesco De Logu et al.   Seminars in Immunopathology

Emerging Role of Spinal Cord TRPV1 in Pain Exacerbation

(2016) Seung-In Choi et al.   NEURAL PLASTICITY

GABA Blocks Pathological but Not Acute TRPV1 Pain Signals

(2015) Christina Hanack et al.   CELL

TRP Channels in Respiratory Pathophysiology: the Role of Oxidative, Chemical Irritant and Temperature Stimuli

(2015) Alexander Zholos   Current Neuropharmacology

TRPV1 Channel: A Potential Drug Target for Treating Epilepsy

(2015) Mustafa Nazıroglu   Current Neuropharmacology

Transient receptor potential vanilloid type-1 channel regulates diet-induced obesity, insulin resistance, and leptin resistance

(2015) Eunjung Lee et al.   FASEB JOURNAL

Proton block of proton-activated TRPV1 current

(2015) Bo Hyun Lee et al.   JOURNAL OF GENERAL PHYSIOLOGY

α-Spinasterol, a TRPV1 receptor antagonist, elevates the seizure threshold in three acute seizure tests in mice

(2015) Katarzyna Socała et al.   JOURNAL OF NEURAL TRANSMISSION

Targeting TRP channels for chronic cough: from bench to bedside

(2015) Sara J. Bonvini et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Effect of hypoxia on TRPV1 and TRPV4 channels in rat pulmonary arterial smooth muscle cells

(2015) Thibaud Parpaite et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The role of TRPV1 in improving VSMC function and attenuating hypertension

(2015) Ming-Jie Zhang et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

TRP channel functions in the gastrointestinal tract

(2015) Xiaoyun Yu et al.   Seminars in Immunopathology

Potential therapeutic value of TRPV1 and TRPA1 in diabetes mellitus and obesity

(2015) Andrei V. Derbenev et al.   Seminars in Immunopathology

Compartment-Specific Modulation of GABAergic Synaptic Transmission by TRPV1 Channels in the Dentate Gyrus

(2014) A. E. Chavez et al.   JOURNAL OF NEUROSCIENCE

Involvement of central TRPV1 receptors in pentylenetetrazole and amygdala-induced kindling in male rats

(2014) Mohsen Shirazi et al.   NEUROLOGICAL SCIENCES

“Hotheaded”: The role OF TRPV1 in brain functions

(2014) D. Martins et al.   NEUROPHARMACOLOGY

Cajal–Retzius cells: Update on structural and functional properties of these mystic neurons that bridged the 20th century

(2014) S. Kirischuk et al.   NEUROSCIENCE

Blocking TRPV1 in Nucleus Accumbens Inhibits Persistent Morphine Conditioned Place Preference Expression in Rats

(2014) Li-Jun Heng et al.   PLoS One

Effects of cannabinoid and vanilloid drugs on positive and negative-like symptoms on an animal model of schizophrenia: The SHR strain

(2014) Valéria Almeida et al.   SCHIZOPHRENIA RESEARCH

TRPV1 activation impedes foam cell formation by inducing autophagy in oxLDL-treated vascular smooth muscle cells

(2014) B-H Li et al.   Cell Death & Disease

Bladder Cancer and Urothelial Impairment: The Role of TRPV1 as Potential Drug Target

(2014) Francesco Mistretta et al.   Biomed Research International

Correlation between Urothelial Differentiation and Sensory Proteins P2X3, P2X5, TRPV1, and TRPV4 in Normal Urothelium and Papillary Carcinoma of Human Bladder

(2014) Igor Sterle et al.   Biomed Research International

Sensitivity Testing in Irritable Bowel Syndrome With Rectal Capsaicin Stimulations: Role of TRPV1 Upregulation and Sensitization in Visceral Hypersensitivity?

(2013) Sander J M van Wanrooij et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

TRP channels in lower urinary tract dysfunction

(2013) J Franken et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRP Channels in Vascular Disorders

(2013) Alexander V. Zholos et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Piperine exerts anti-seizure effects via the TRPV1 receptor in mice

(2013) Chang-Yuan Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Increased expression of bronchial epithelial transient receptor potential vanilloid 1 channels in patients with severe asthma

(2013) Lorcan P. McGarvey et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

Depressive behavior in the forced swim test can be induced by TRPV1 receptor activity and is dependent on NMDA receptors

(2013) Ramy E. Abdelhamid et al.   PHARMACOLOGICAL RESEARCH

Targeting TRPV1 and TRPV2 for potential therapeutic interventions in cardiovascular disease

(2013) Nathan Robbins et al.   Translational Research

Increased Expression of TRPV1 in the Cortex and Hippocampus from Patients with Mesial Temporal Lobe Epilepsy

(2012) Fei-Ji Sun et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

TRPV1 in GABAergic Interneurons Mediates Neuropathic Mechanical Allodynia and Disinhibition of the Nociceptive Circuitry in the Spinal Cord

(2012) Yong Ho Kim et al.   NEURON

Why do cannabinoid receptors have more than one endogenous ligand?

(2012) V. Di Marzo et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Activation of TRPV1 reduces vascular lipid accumulation and attenuates atherosclerosis

(2011) Liqun Ma et al.   CARDIOVASCULAR RESEARCH

Trpv1 Reporter Mice Reveal Highly Restricted Brain Distribution and Functional Expression in Arteriolar Smooth Muscle Cells

(2011) D. J. Cavanaugh et al.   JOURNAL OF NEUROSCIENCE

Capsaicin prevents kainic acid-induced epileptogenesis in mice

(2011) Tae-Hee Lee et al.   NEUROCHEMISTRY INTERNATIONAL

Alterations in the emotional and memory behavioral phenotypes of transient receptor potential vanilloid type 1-deficient mice are mediated by changes in expression of 5-HT1A, GABAA, and NMDA receptors

(2011) In-Jee You et al.   NEUROPHARMACOLOGY

Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system

(2011) Peter Holzer   PHARMACOLOGY & THERAPEUTICS

TRPV channels and vascular function

(2010) R. L. Baylie et al.   Acta Physiologica

Activation of TRPV1 by Dietary Capsaicin Improves Endothelium-Dependent Vasorelaxation and Prevents Hypertension

(2010) Dachun Yang et al.   Cell Metabolism

Differential Cardiac Remodeling in Preload Versus Afterload

(2010) Karl Toischer et al.   CIRCULATION

Effects of TRPV1 activation on synaptic excitation in the dentate gyrus of a mouse model of temporal lobe epilepsy

(2010) Muthu D. Bhaskaran et al.   EXPERIMENTAL NEUROLOGY

GABAA receptor associated protein (GABARAP) modulates TRPV1 expression and channel function and desensitization

(2010) S. Laínez et al.   FASEB JOURNAL

TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus

(2010) Andrés E Chávez et al.   NATURE NEUROSCIENCE

Postsynaptic TRPV1 triggers cell type–specific long-term depression in the nucleus accumbens

(2010) Brad A Grueter et al.   NATURE NEUROSCIENCE

Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon

(2009) Kenjiro Matsumoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

TRPV1 channels facilitate glutamate transmission in the striatum

(2008) Alessandra Musella et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Role of ionotropic cannabinoid receptors in peripheral antinociception and antihyperalgesia

(2008) Armen N. Akopian et al.   TRENDS IN PHARMACOLOGICAL SCIENCES