Targeting TRP channels for chronic cough: from bench to bedside

Single-cell RT-PCR and immunocytochemical detection of mechanosensitive transient receptor potential channels in acutely isolated rat odontoblasts

(2014) Minsoo Kwon et al.   ARCHIVES OF ORAL BIOLOGY

Theophylline inhibits the cough reflex through a novel mechanism of action

(2014) Eric Dubuis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Transient Receptor Potential Ankyrin 1 Receptor Activation In Vitro and In Vivo by Pro-tussive Agents: GRC 17536 as a Promising Anti-Tussive Therapeutic

(2014) Indranil Mukhopadhyay et al.   PLoS One

Predictors of Objective Cough Frequency in Chronic Obstructive Pulmonary Disease

(2013) Helen Sumner et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Transient receptor potential (TRP) channels in the airway: role in airway disease

(2013) M S Grace et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transient receptor potential (TRP) channels: a clinical perspective

(2013) Yosuke Kaneko et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activation of Transient Receptor Potential Ankyrin-1 (TRPA1) in Lung Cells by Wood Smoke Particulate Material

(2013) Darien Shapiro et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Multiple Roles of Transient Receptor Potential (TRP) Channels in Inflammatory Conditions and Current Status of Drug Development

(2013) Olivier Radresa et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Cough frequency in health and disease

(2013) N. Yousaf et al.   EUROPEAN RESPIRATORY JOURNAL

The role of trigeminal nasal TRPM8-expressing afferent neurons in the antitussive effects of menthol

(2013) J. Plevkova et al.   JOURNAL OF APPLIED PHYSIOLOGY

Protease-activated Receptor 2 (PAR2) Protein and Transient Receptor Potential Vanilloid 4 (TRPV4) Protein Coupling Is Required for Sustained Inflammatory Signaling

(2013) Daniel P. Poole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contribution of TRPA1 as a Downstream Signal of Proteinase-Activated Receptor-2 to Pancreatic Pain

(2013) Yuka Terada et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Pre-clinical studies in cough research: Role of Transient Receptor Potential (TRP) channels

(2013) Megan S. Grace et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

TRPV1 induction in airway vagal low-threshold mechanosensory neurons by allergen challenge and neurotrophic factors

(2012) Tina Marie Lieu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

TRPA1: A Gatekeeper for Inflammation

(2012) Diana M. Bautista et al.   Annual Review of Physiology

Quantitative analysis of TRP channel genes in mouse organs

(2012) Yongwoo Jang et al.   ARCHIVES OF PHARMACAL RESEARCH

Comparison of TRPA1-versus TRPV1-mediated cough in guinea pigs

(2012) Mariana Brozmanova et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TRP channels as therapeutic targets in airway disorders: a patent review

(2012) Delia Preti et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

TRPM8 Ion Channels Differentially Modulate Proliferation and Cell Cycle Distribution of Normal and Cancer Prostate Cells

(2012) María Ll. Valero et al.   PLoS One

Sweet taste and menthol increase cough reflex thresholds

(2012) Paul M. Wise et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Transient receptor potential genes, smoking, occupational exposures and cough in adults

(2012) Lidwien AM Smit et al.   RESPIRATORY RESEARCH

An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure

(2012) Kevin S. Thorneloe et al.   Science Translational Medicine

P159 Validation of the VitaloJAK™ 24 Hour Ambulatory Cough Monitor: Abstract P159 Table 1

(2012) K McGuinness et al.   THORAX

Transient receptor potential channels mediate the tussive response to prostaglandin E2and bradykinin

(2012) Megan Grace et al.   THORAX

Randomised clinical trial: the efficacy of a transient receptor potential vanilloid 1 antagonist AZD1386 in human oesophageal pain

(2011) A. L. Krarup et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

An investigation of the safety and pharmacokinetics of the novel TRPV1 antagonist XEN-D0501 in healthy subjects

(2011) Patrick Round et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Cigarette smoke and α,β-unsaturated aldehydes elicit VEGF release through the p38 MAPK pathway in human airway smooth muscle cells and lung fibroblasts

(2011) Giorgia Volpi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transient Receptor Potential A1 Channels

(2011) Maria G. Belvisi et al.   CHEST

Antitussive Effects of Memantine in Guinea Pigs

(2011) Jaclyn A. Smith et al.   CHEST

Pharmacologic therapy for cough

(2011) Emma C Young et al.   CURRENT OPINION IN PHARMACOLOGY

Therapeutic Targeting of TRP Channels - The TR(i)P to Pain Relief

(2011) Samer R. Eid   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4-d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist

(2011) Michael P. Maher et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants

(2011) Daniel N. Willis et al.   FASEB JOURNAL

Identification of a Binding Motif in the S5 Helix That Confers Cholesterol Sensitivity to the TRPV1 Ion Channel

(2011) Giovanni Picazo-Juárez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells

(2011) Indranil Mukhopadhyay et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

TRPA1 underlies a sensing mechanism for O2

(2011) Nobuaki Takahashi et al.   Nature Chemical Biology

Transient receptor potential channels as therapeutic targets

(2011) Magdalene M. Moran et al.   NATURE REVIEWS DRUG DISCOVERY

TRP channels: Emerging targets for respiratory disease

(2011) Katharine Helen Banner et al.   PHARMACOLOGY & THERAPEUTICS

Sensitivity of bronchopulmonary receptors to cold and heat mediated by transient receptor potential cation channel subtypes in an ex vivo rat lung preparation

(2011) Yun Zhou et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Encoding of the cough reflex in anesthetized guinea pigs

(2010) Brendan J. Canning et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Distinct expression of cold receptors (TRPM8 and TRPA1) in the rat nodose–petrosal ganglion complex

(2010) Aki Hondoh et al.   BRAIN RESEARCH

Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators

(2010) Nobuaki Takahashi et al.   Channels

A Novel Approach to Studying the Relationship Between Subjective and Objective Measures of Cough

(2010) Angela Kelsall et al.   CHEST

Activations of TRPA1 and P2X receptors are important in ROS-mediated stimulation of capsaicin-sensitive lung vagal afferents by cigarette smoke in rats

(2010) You Shuei Lin et al.   JOURNAL OF APPLIED PHYSIOLOGY

Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents

(2010) Amol M. Patwardhan et al.   JOURNAL OF CLINICAL INVESTIGATION

Cough: A Worldwide Problem

(2010) J. Mark Madison et al.   OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA

TRPA1 receptors in cough

(2010) Megan S. Grace et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Effect of viral upper respiratory tract infection on the urge-to-cough sensation

(2010) Peter V. Dicpinigaitis et al.   RESPIRATORY MEDICINE

Heteromerization of TRP channel subunits: extending functional diversity

(2010) Wei Cheng et al.   Protein & Cell

Monitoring chronic cough: current and future techniques

(2010) Jaclyn Smith   Expert Review of Respiratory Medicine

TRPA1 Agonists Evoke Coughing in Guinea Pig and Human Volunteers

(2009) Mark A. Birrell et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Prostaglandin E2Mediates Cough via the EP3Receptor

(2009) Sarah A. Maher et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Identification and characterization of novel TRPV4 modulators

(2009) Fabien Vincent et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents

(2009) E Andrè et al.   BRITISH JOURNAL OF PHARMACOLOGY

Association of TRPV4 gene polymorphisms with chronic obstructive pulmonary disease

(2009) G. Zhu et al.   HUMAN MOLECULAR GENETICS

Adverse reactions to over-the-counter cough and cold products among children: the cases managed out of hospitals

(2009) Z. P. Vassilev et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels

(2009) Thomas E. Taylor-Clark et al.   JOURNAL OF PHYSIOLOGY-LONDON

Prostanoids and the Cough Reflex

(2009) Sarah A. Maher et al.   LUNG

Use of sensory methods for detecting target engagement in clinical trials of new analgesics

(2009) Boris A. Chizh et al.   Neurotherapeutics

Modulation of sensory nerve function and the cough reflex: Understanding disease pathogenesis

(2009) Julie Nasra et al.   PHARMACOLOGY & THERAPEUTICS

A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma

(2009) A. I. Caceres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The vanilloid transient receptor potential channel TRPV4: From structure to disease

(2009) Wouter Everaerts et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

TRPA1: A potential target for anti-tussive therapy

(2009) Thomas E. Taylor-Clark et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Cough and viruses in airways disease: Mechanisms

(2009) Joseph Footitt et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Structure–functional intimacies of transient receptor potential channels

(2009) Ramon Latorre et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Differential effects of airway afferent nerve subtypes on cough and respiration in anesthetized guinea pigs

(2008) Yang-Ling Chou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Herbal Compounds and Toxins Modulating TRP Channels

(2008) Rudi Vennekens et al.   Current Neuropharmacology

Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway

(2008) Martin J. Gunthorpe et al.   DRUG DISCOVERY TODAY

Activation of transient receptor potential ankyrin 1 by hydrogen peroxide

(2008) Yosuke Sawada et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The Leicester Cough Monitor: a semi-automated, semi-validated cough detection system?

(2008) K. McGuinness et al.   EUROPEAN RESPIRATORY JOURNAL

The Leicester Cough Monitor: preliminary validation of an automated cough detection system in chronic cough

(2008) S. S. Birring et al.   EUROPEAN RESPIRATORY JOURNAL

TRPA1 is a major oxidant sensor in murine airway sensory neurons

(2008) Bret F. Bessac et al.   JOURNAL OF CLINICAL INVESTIGATION

Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress

(2008) D. A. Andersson et al.   JOURNAL OF NEUROSCIENCE

N-((1S)-1- -3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Part I

(2008) K. S. Thorneloe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Plant-Derived Cannabinoids Modulate the Activity of Transient Receptor Potential Channels of Ankyrin Type-1 and Melastatin Type-8

(2008) L. De Petrocellis et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs

(2008) Christina Nassenstein et al.   JOURNAL OF PHYSIOLOGY-LONDON

Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal

(2008) T. E. Taylor-Clark et al.   JOURNAL OF PHYSIOLOGY-LONDON

TRPM8 Mechanism of Autonomic Nerve Response to Cold in Respiratory Airway

(2008) Hong Xing et al.   Molecular Pain

Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans

(2008) Narender R. Gavva et al.   PAIN

Is TRPV1 a useful target in respiratory diseases?

(2008) Masaya Takemura et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Impact of Cough Across Different Chronic Respiratory Diseases

(2007) Liam Polley et al.   CHEST