Article
Oncology
Hongzhi Liu, Lianku Lin, Ziguo Lin, Yifan Chen, Qizhen Huang, Lei Ding, Jianying Lou, Shuguo Zheng, Xinyu Bi, Jianming Wang, Wei Guo, Fuyu Li, Jian Wang, Yamin Zheng, Jingdong Li, Shi Cheng, Weiping Zhou, Zhangjun Cheng, Yongyi Zeng
Summary: This study found that wide margin hepatectomy (WMH) can significantly improve the survival outcomes of patients with intrahepatic cholangiocarcinoma (ICC), especially in patients with AJCC stage I.
Article
Surgery
Hongxu Zhu, Longrong Wang, Miao Wang, Xigan He, Weiqi Xu, Weiping Zhu, Yiming Zhao, Lu Wang
Summary: This study suggests that a resection margin length >= 1.0 cm is associated with significantly improved survival in patients undergoing resection for intrahepatic cholangiocarcinoma (ICC). Therefore, achieving a clear margin of at least 1.0 cm during ICC resection is recommended for better outcomes.
AMERICAN JOURNAL OF SURGERY
(2021)
Review
Surgery
Ali Ramouz, Sadeq Ali-Hasan-Al-Saegh, Saeed Shafiei, Sanam Fakour, Elias Khajeh, Ali Majlesara, Ali Adeliansedehi, Pascal Probst, Christoph Springfeld, De-Hua Chang, Christian Rupp, Carlos Carvalho, Mohammad Golriz, Katrin Hoffmann, Arianeb Mehrabi
Summary: Repeat liver resection is a suitable strategy for the treatment of recurrent intrahepatic cholangiocarcinoma, improving short- and long-term outcomes compared to non-surgical approaches.
BRITISH JOURNAL OF SURGERY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Gun Ha Kim, Pyeong Hwa Kim, Jin Hyoung Kim, Pyo-Nyun Kim, Hyung Jin Won, Yong Moon Shin, Sang Hyun Choi
Summary: Thermal ablation for intrahepatic cholangiocarcinoma demonstrates high technical efficacy and low incidence of complications, particularly effective for single tumors smaller than 3 cm in diameter.
EUROPEAN RADIOLOGY
(2022)
Review
Oncology
Yu-Shi Dai, Hai-Jie Hu, Tian-run Lv, Ya-Fei Hu, Rui-Qi Zou, Fu-Yu Li
Summary: Based on literature research and statistical analysis conducted until December 31, 2021, it was found that a resection margin width of over 10 mm can improve the prognosis of intrahepatic cholangiocarcinoma patients, especially those with negative lymph nodes and early tumor stages. If the resection margin width cannot exceed 10 mm, it is recommended to ensure a width greater than 5 mm.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yuma Wada, Mitsuo Shimada, Kensuke Yamamura, Takeo Toshima, Jasjit K. Banwait, Yuji Morine, Tetsuya Ikemoto, Yu Saito, Hideo Baba, Masaki Mori, Ajay Goel
Summary: Genome-wide expression profile analyses were conducted to identify a gene signature associated with recurrence in patients with ICC. An eight-gene panel was discovered and validated to robustly identify recurrence in ICC patients, leading to the establishment of a risk-stratification model.
Review
Oncology
Amram Kupietzky, Arie Ariche
Summary: This paper reviews the surgical management of intrahepatic cholangiocarcinoma (ICC), highlighting surgical resection as the only curative treatment for ICC.
Review
Oncology
Feiyu Li, Yong Jiang, Liyong Jiang, Qingbin Li, Xiangyu Yan, Songhan Huang, Ji Chen, Shuai Yuan, Yingda Fu, Jun Liu
Summary: The results of this meta-analysis indicate that lymph node dissection does not seem to have a positive effect on overall survival and disease-free survival in patients with intrahepatic cholangiocarcinoma (ICC).
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Woo Jin Choi, Phil J. Williams, Marco P. A. W. Claasen, Tommy Ivanics, Marina Englesakis, Steven Gallinger, Bettina Hansen, Gonzalo Sapisochin
Summary: This systematic review identifies prognostic factors for early recurrence and 24-month disease-free survival after curative-intent resection of intrahepatic cholangiocarcinoma (iCCA). Multiple tumors, microvascular invasion, macrovascular invasion, lymph node metastasis, and R1 resection were associated with increased risk for early recurrence or reduced 24-month disease-free survival. Receipt of adjuvant chemo/radiation therapy was associated with improved outcomes. Cirrhosis, sex, and HBV status were not associated with early recurrence or 24-month disease-free survival.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Surgery
Nikolaos Machairas, Ioannis D. Kostakis, Dimitrios Schizas, Stylianos Kykalos, Nikolaos Nikiteas, Georgios C. Sotiropoulos
Summary: The study found that compared to open liver resection, laparoscopic surgery in the treatment of intrahepatic cholangiocarcinoma results in smaller tumors, less extensive resections, higher R0 resection rates, less blood loss, lower transfusion requirements, decreased overall morbidity, and shorter hospital stays. However, there were no significant differences between the two groups in terms of operative time, major complications, mortality, and long-term survival rates.
UPDATES IN SURGERY
(2021)
Article
Multidisciplinary Sciences
Gaobo Huang, Weilun Song, Yanchao Zhang, Jiawei Yu, Yi Lv, Kang Liu
Summary: This study investigated the role of liver transplantation (LT) in patients with intrahepatic cholangiocarcinoma (ICC) compared to liver resection (LR) in ICC patients and LT in hepatocellular carcinoma (HCC) patients. The results showed that the prognosis of ICC patients after LT was better than after LR, but still worse than HCC patients after LT.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Jiawei Xie, Xiaohong Pu, Jian He, Yudong Qiu, Cheng Lu, Wei Gao, Xiangxue Wang, Haoda Lu, Jiong Shi, Yuemei Xu, Anant Madabhushi, Xiangshan Fan, Jun Chen, Jun Xu
Summary: Intrahepatic cholangiocarcinoma (ICC) is a type of cancer originating from the liver's secondary ductal epithelium or branch. Due to a lack of early clinical symptoms and high mortality, accurately predicting survival status and providing appropriate treatment is crucial. This study aimed to develop quantitative histomorphological features to describe lymphocyte density distribution at the cell level and different components at the tissue level in ICC patients. The results showed that these features could stratify patients' survival risk.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Review
Surgery
Anne-Marleen van Keulen, Stefan Buttner, Joris I. Erdmann, Jeroen Hagendoorn, Frederik J. H. Hoogwater, Jan N. M. IJzermans, Ulf P. Neumann, Wojciech G. Polak, Jeroen De Jonge, Pim B. Olthof, Bas Groot Koerkamp
Summary: A systematic review and meta-analysis revealed that the risk of major complications and mortality after resection of intrahepatic cholangiocarcinoma was assessed. The study found that in-hospital, 30-day, and 90-day mortality rates were 5.9%, 4.6%, and 6.1% respectively, while the proportion of major complications was 22.2%.
Article
Oncology
Elishama N. Kanu, Kristen E. Rhodin, Sabran J. Masoud, Austin M. Eckhoff, Alex J. Bartholomew, Thomas C. Howell, Jiayin Bao, Nicholas T. Befera, Charles Y. Kim, Dan G. Blazer, Sabino Zani, Daniel P. Nussbaum, Peter J. Allen, Michael E. Lidsky
Summary: A retrospective analysis was conducted to compare the outcomes of resection and ablation for intrahepatic cholangiocarcinoma (iCCA) using a national cancer registry. The results showed that the choice of treatment strategy for iCCA is influenced by tumor size. Resection and ablation had similar overall survival rates for tumors smaller than 3 cm, suggesting that ablation may be a viable alternative therapeutic strategy for small iCCA.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Letter
Oncology
Yutaro Hori, Tomoaki Yoh, Satoru Seo, Sachiko Minamiguchi, Hironori Haga, Kojiro Taura
Summary: This letter to the editor highlights the importance of HER2 expression as a potential target for adjuvant therapy in biliary tract cancer, with a specific focus on patients with intrahepatic cholangiocarcinoma.