UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes

CRISPR-Cas9-modifiedpfmdr1protectsPlasmodium falciparumasexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based combination therapy partner drugs

(2016) Caroline L. Ng et al.   MOLECULAR MICROBIOLOGY

Understanding transport by the major facilitator superfamily (MFS): structures pave the way

(2016) Esben M. Quistgaard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes

(2016) C. D. Goodman et al.   SCIENCE

Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug Resistance

(2016) Gregory LaMonte et al.   mBio

Structural Biology of the Major Facilitator Superfamily Transporters

(2015) Nieng Yan   Annual Review of Biophysics

A new case of UDP-galactose transporter deficiency (SLC35A2-CDG): molecular basis, clinical phenotype, and therapeutic approach

(2015) K. Dörre et al.   JOURNAL OF INHERITED METABOLIC DISEASE

A novel multiple-stage antimalarial agent that inhibits protein synthesis

(2015) Beatriz Baragaña et al.   NATURE

A First-in-Human Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Oral Dose Study of Novel Imidazolopiperazine KAF156 To Assess Its Safety, Tolerability, and Pharmacokinetics in Healthy Adult Volunteers

(2014) F. Joel Leong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

KAF156 Is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission

(2014) Kelli L. Kuhen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of pathogen genomic variants through an integrated pipeline

(2014) Micah J Manary et al.   BMC BIOINFORMATICS

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

(2014) Elizabeth A. Ashley et al.   NEW ENGLAND JOURNAL OF MEDICINE

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance ofPlasmodium

(2014) María Belén Jiménez-Díaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRISPR-mediated genome editing of Plasmodium falciparum malaria parasites

(2014) Marcus CS Lee et al.   Genome Medicine

Efflux pump proteins in antifungal resistance

(2014) Rajendra Prasad et al.   Frontiers in Pharmacology

MFS transporters required for multidrug/multixenobiotic (MD/MX) resistance in the model yeast: understanding their physiological function through post-genomic approaches

(2014) Sandra C. dos Santos et al.   Frontiers in Physiology

Mosaicism of the UDP-Galactose Transporter SLC35A2 Causes a Congenital Disorder of Glycosylation

(2013) Bobby G. Ng et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Using Genetic Methods To Define the Targets of Compounds with Antimalarial Activity

(2013) Erika L. Flannery et al.   JOURNAL OF MEDICINAL CHEMISTRY

The acetyl-CoA transporter family SLC33

(2013) Yoshio Hirabayashi et al.   MOLECULAR ASPECTS OF MEDICINE

Crystal structure of a eukaryotic phosphate transporter

(2013) Bjørn P. Pedersen et al.   NATURE

Targeting Plasmodium PI(4)K to eliminate malaria

(2013) Case W. McNamara et al.   NATURE

Imidazolopiperazines: Lead Optimization of the Second-Generation Antimalarial Agents

(2012) Advait Nagle et al.   JOURNAL OF MEDICINAL CHEMISTRY

A framework for assessing the risk of resistance for anti-malarials in development

(2012) Xavier C Ding et al.   MALARIA JOURNAL

PfCRT and its role in antimalarial drug resistance

(2012) Andrea Ecker et al.   TRENDS IN PARASITOLOGY

Confronting the Challenges of Natural Product-Based Antifungal Discovery

(2011) Terry Roemer et al.   CHEMISTRY & BIOLOGY

Imidazolopiperazines: Hit to Lead Optimization of New Antimalarial Agents

(2011) Tao Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

(2011) S. Meister et al.   SCIENCE

A rapid and robust tri-color flow cytometry assay for monitoring malaria parasite development

(2011) Benoît Malleret et al.   Scientific Reports

AT-1 is the ER membrane acetyl-CoA transporter and is essential for cell viability

(2010) M. C. Jonas et al.   JOURNAL OF CELL SCIENCE

Complementation of Saccharomyces cerevisiae pik1ts by a phosphatidylinositol 4-kinase from Plasmodium falciparum

(2010) Tim Krüger et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Plasmodium falciparumSec24 marks transitional ER that exports a model cargo via a diacidic motif

(2008) Marcus C. S. Lee et al.   MOLECULAR MICROBIOLOGY

PlasmoDB: a functional genomic database for malaria parasites

(2008) C. Aurrecoechea et al.   NUCLEIC ACIDS RESEARCH