Building C(sp3)-rich complexity by combining cycloaddition and C–C cross-coupling reactions

Decarboxylative alkenylation

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The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex

(2017) Yupeng He et al.   Nature Chemical Biology

Nickel-Catalyzed Cross-Coupling of Redox-Active Esters with Boronic Acids

(2016) Jie Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Advances in the Synthesis of Cyclobutanes by Olefin [2 + 2] Photocycloaddition Reactions

(2016) Saner Poplata et al.   CHEMICAL REVIEWS

Big Data from Pharmaceutical Patents: A Computational Analysis of Medicinal Chemists’ Bread and Butter

(2016) Nadine Schneider et al.   JOURNAL OF MEDICINAL CHEMISTRY

Practical Ni-Catalyzed Aryl–Alkyl Cross-Coupling of Secondary Redox-Active Esters

(2016) Josep Cornella et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Ireland–Claisen rearrangement strategy towards the synthesis of the schizophrenia drug, (+)-asenapine

(2016) Raghunath Reddy Anugu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents

(2016) T. Qin et al.   SCIENCE

Attractive natural products with strained cyclopropane and/or cyclobutane ring systems

(2016) Yao-Yue Fan et al.   Science China-Chemistry

Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

(2015) Dean G. Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Asymmetric Cyclopropanation Reactions

(2014) Renato Dalpozzo et al.   SYNTHESIS-STUTTGART

Iron-Catalyzed Suzuki−Miyaura Coupling of Alkyl Halides

(2010) Takuji Hatakeyama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

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Epothilones: a novel class of microtubule-stabilizing drugs for the treatment of cancer

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