Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles

ADAM8 as a drug target in pancreatic cancer

(2015) Uwe Schlomann et al.   Nature Communications

The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases

(2014) Christoph Garbers et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Senescence-associated release of transmembrane proteins involves proteolytic processing by ADAM17 and microvesicle shedding

(2014) Timo Effenberger et al.   FASEB JOURNAL

A Disintegrin and Metalloprotease 17 Dynamic Interaction Sequence, the Sweet Tooth for the Human Interleukin 6 Receptor

(2014) Stefan Düsterhöft et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-6 biology: implications for clinical targeting in rheumatic disease

(2014) Leonard H. Calabrese et al.   Nature Reviews Rheumatology

A Disintegrin and Metalloprotease (ADAM) 10 and ADAM17 Are Major Sheddases of T Cell Immunoglobulin and Mucin Domain 3 (Tim-3)

(2013) Katja Möller-Hackbarth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-6: From basic biology to selective blockade of pro-inflammatory activities

(2013) Jürgen Scheller et al.   SEMINARS IN IMMUNOLOGY

Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases

(2013) Ricardo C. Ferreira et al.   PLoS Genetics

The interleukin 6 pathway and atherosclerosis

(2012) Jürgen Scheller et al.   LANCET

Amphiregulin Exosomes Increase Cancer Cell Invasion

(2011) James N. Higginbotham et al.   CURRENT BIOLOGY

The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling

(2011) S. Weber et al.   DEVELOPMENT

Species Specificity of ADAM10 and ADAM17 Proteins in Interleukin-6 (IL-6) Trans-signaling and Novel Role of ADAM10 in Inducible IL-6 Receptor Shedding

(2011) Christoph Garbers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of IL6R and chromosome 11q13.5 as risk loci for asthma

(2011) Manuel AR Ferreira et al.   LANCET

Cross-domain inhibition of TACE ectodomain

(2011) C. J. Tape et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The soluble Interleukin 6 receptor: Generation and role in inflammation and cancer

(2010) Athena Chalaris et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice

(2010) Athena Chalaris et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differences in Wound Healing in Mice with Deficiency of IL-6 versus IL-6 Receptor

(2010) M. M. McFarland-Mancini et al.   JOURNAL OF IMMUNOLOGY

The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex

(2010) E. Jorissen et al.   JOURNAL OF NEUROSCIENCE

ADAMs 10 and 17 Represent Differentially Regulated Components of a General Shedding Machinery for Membrane Proteins Such as Transforming Growth Factor α, L-Selectin, and Tumor Necrosis Factor α

(2009) Sylvain M. Le Gall et al.   MOLECULAR BIOLOGY OF THE CELL

Shedding microvesicles: artefacts no more

(2009) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

Molecular Mechanisms of Soluble Cytokine Receptor Generation

(2008) Stewart J. Levine   JOURNAL OF BIOLOGICAL CHEMISTRY

Circulating TNFR1 exosome-like vesicles partition with the LDL fraction of human plasma

(2007) Jing Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neutrophil elastase, proteinase 3 and cathepsin G: Physicochemical properties, activity and physiopathological functions

(2007) Brice Korkmaz et al.   BIOCHIMIE

Generation of novel, secreted epidermal growth factor receptor (EGFR/ErbB1) isoforms via metalloprotease-dependent ectodomain shedding and exosome secretion

(2007) Michael P. Sanderson et al.   JOURNAL OF CELLULAR BIOCHEMISTRY