Therapeutic potential of silymarin in chronic unpredictable mild stress induced depressive-like behavior in mice

Silymarin ameliorates experimentally induced depressive like behavior in rats: Involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response

(2017) Vishnu N. Thakare et al.   PHYSIOLOGY & BEHAVIOR

Resveratrol exerts antidepressant properties in the chronic unpredictable mild stress model through the regulation of oxidative stress and mTOR pathway in the rat hippocampus and prefrontal cortex

(2016) Song liu et al.   BEHAVIOURAL BRAIN RESEARCH

Berberine up-regulates the BDNF expression in hippocampus and attenuates corticosterone-induced depressive-like behavior in mice

(2016) Ji-duo Shen et al.   NEUROSCIENCE LETTERS

Potential antidepressant-like activity of silymarin in the acute restraint stress in mice: Modulation of corticosterone and oxidative stress response in cerebral cortex and hippocampus

(2016) Vishnu N. Thakare et al.   Pharmacological Reports

Thymol produces an antidepressant-like effect in a chronic unpredictable mild stress model of depression in mice

(2015) Xue-Yang Deng et al.   BEHAVIOURAL BRAIN RESEARCH

Silymarin has antioxidant potential and changes the activity of Na+/K+-ATPase and monoamine oxidase in vitro

(2015) Dayanne Rakelly de Oliveira et al.   INDUSTRIAL CROPS AND PRODUCTS

Chronic unpredictable mild stress decreases BDNF and NGF levels and Na+,K+-ATPase activity in the hippocampus and prefrontal cortex of mice: Antidepressant effect of chrysin

(2015) C.B. Filho et al.   NEUROSCIENCE

l-Menthone confers antidepressant-like effects in an unpredictable chronic mild stress mouse model via NLRP3 inflammasome-mediated inflammatory cytokines and central neurotransmitters

(2015) Jinsong Xue et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Antidepressant-like effect of quercetin in bulbectomized mice and involvement of the antioxidant defenses, and the glutamatergic and oxidonitrergic pathways

(2015) Iandra Holzmann et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Inflammation, Glutamate, and Glia in Depression: A Literature Review

(2015) Leah McNally et al.   CNS SPECTRUMS

Resveratrol reverses the effects of chronic unpredictable mild stress on behavior, serum corticosterone levels and BDNF expression in rats

(2014) Dexiang Liu et al.   BEHAVIOURAL BRAIN RESEARCH

Genipin is active via modulating monoaminergic transmission and levels of brain-derived neurotrophic factor (BDNF) in rat model of depression

(2014) Q.-S. Wang et al.   NEUROSCIENCE

Cytokines, prostaglandins and nitric oxide in the regulation of stress-response systems

(2014) Anna Gądek-Michalska et al.   Pharmacological Reports

Neuroprotective effect of silymarin in a MPTP mouse model of Parkinson's disease

(2014) Jesús Pérez-H et al.   TOXICOLOGY

Antidepressant-like activity of beta-carotene in unstressed and chronic unpredictable mild stressed mice

(2014) Dinesh Dhingra et al.   Journal of Functional Foods

Inflammasomes in neuroinflammation and changes in brain function: a focused review

(2014) Gaurav Singhal et al.   Frontiers in Neuroscience

Antidepressant-like responses in the forced swimming test elicited by glutathione and redox modulation

(2013) Juliana M. Rosa et al.   BEHAVIOURAL BRAIN RESEARCH

Brain-derived neurotrophic factor signalling mediates the antidepressant-like effect of piperine in chronically stressed mice

(2013) Qing-Qiu Mao et al.   BEHAVIOURAL BRAIN RESEARCH

Neuroprotective Potential of Silymarin against CNS Disorders: Insight into the Pathways and Molecular Mechanisms of Action

(2013) Anupom Borah et al.   CNS Neuroscience & Therapeutics

Amelioration of cognitive, motor and endogenous defense functions with silymarin, piracetam and protocatechuic acid in the cerebral global ischemic rat model

(2013) Milind M. Muley et al.   LIFE SCIENCES

Etazolate, a phosphodiesterase 4 inhibitor reverses chronic unpredictable mild stress-induced depression-like behavior and brain oxidative damage

(2013) Ankur Jindal et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Agmatine abolishes restraint stress-induced depressive-like behavior and hippocampal antioxidant imbalance in mice

(2013) Andiara E. Freitas et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Neuroprotective effects of silymarin on sodium fluoride-induced oxidative stress

(2012) Seyed Mohammad Nabavi et al.   JOURNAL OF FLUORINE CHEMISTRY

Silymarin improves the behavioural, biochemical and histoarchitecture alterations in focal ischemic rats: A comparative evaluation with piracetam and protocatachuic acid

(2012) Milind M. Muley et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders: A systematic review and meta-regression analysis

(2011) Brisa Simões Fernandes et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Depressive-like behavior induced by tumor necrosis factor-α in mice

(2011) Manuella P. Kaster et al.   NEUROPHARMACOLOGY

Long-term treatment with peony glycosides reverses chronic unpredictable mild stress-induced depressive-like behavior via increasing expression of neurotrophins in rat brain

(2010) Qing-Qiu Mao et al.   BEHAVIOURAL BRAIN RESEARCH

Chronic antidepressant administration alleviates frontal and hippocampal BDNF deficits in CUMS rat

(2010) Yang Zhang et al.   BRAIN RESEARCH

Open questions in current models of antidepressant action

(2010) A Tanti et al.   BRITISH JOURNAL OF PHARMACOLOGY

Protective effect of curcumin on experimentally induced inflammation, hepatotoxicity and cardiotoxicity in rats: Evidence of its antioxidant property

(2010) Suresh R Naik et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Neuroprotective effect of silymarin in 6-hydroxydopamine hemi-parkinsonian rat: Involvement of estrogen receptors and oxidative stress

(2010) Tourandokht Baluchnejadmojarad et al.   NEUROSCIENCE LETTERS

Neuropsychopharmacological effect of sesamol in unpredictable chronic mild stress model of depression: behavioral and biochemical evidences

(2010) Baldeep Kumar et al.   PSYCHOPHARMACOLOGY

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

The varying effects of short-term and long-term corticosterone injections on depression-like behavior in mice

(2009) Yunan Zhao et al.   BRAIN RESEARCH

Elevation by Oxidative Stress and Aging of Hypothalamic-Pituitary-Adrenal Activity in Rats and Its Prevention by Vitamin E

(2009) Naoko Kobayashi et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Managing Weight Gain and Metabolic Issues in Patients Treated With Atypical Antipsychotics

(2009) David C. Henderson   JOURNAL OF CLINICAL PSYCHIATRY

Neuroimmune mechanisms of cytokine-induced depression: Current theories and novel treatment strategies

(2009) Jennifer M. Loftis et al.   NEUROBIOLOGY OF DISEASE

Effects of acupuncture on chronic corticosterone-induced depression-like behavior and expression of neuropeptide Y in the rats

(2009) Bombi Lee et al.   NEUROSCIENCE LETTERS

Quercetin Protects Against Acute Immobilization Stress-Induced Behaviors and Biochemical Alterations in Mice

(2008) Anil Kumar et al.   JOURNAL OF MEDICINAL FOOD

Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine

(2008) Francesco Matrisciano et al.   JOURNAL OF PSYCHIATRIC RESEARCH

The link between childhood trauma and depression: Insights from HPA axis studies in humans

(2008) Christine Heim et al.   PSYCHONEUROENDOCRINOLOGY