Article
Plant Sciences
Dool-Ri Oh, Chulyung Choi, Moon Jong Kim, Bo Yeong Mun, Haeju Ko, Kyo-Nyeo Oh, Ara Jo, Jin Young Kim, Donghyuck Bae
Summary: This study investigated the effects and mechanism of action of p-coumaric acid (CA), the main active component of Vaccinium bracteatum Thunb. leaves (VBL), on chronic restraint stress (CRS)-induced depression-like behavior. The results showed that CA exhibited antidepressant effects by modulating the levels of neurotransmitters such as dopamine and norepinephrine, as well as the ERK/Akt/mTOR signaling pathways.
Article
Plant Sciences
Ya-Ling Zhang, Kui Lin-Wang, Nick W. Albert, Caitlin Elborough, Richard V. Espley, Christelle M. Andre, Zhi-Zhen Fang
Summary: The study identified the accumulated anthocyanins and their derivatives in Wufanshu berries, discovered candidate anthocyanin biosynthetic genes, and confirmed the important role of the VbMYBA gene in regulating anthocyanin accumulation. Transient expression of VbMYBA in tobacco leaves resulted in higher anthocyanin concentration compared to blueberry VcMYBA expression, demonstrating its ability to activate anthocyanin promoters in other Vaccinium species. These findings provide valuable insights into the molecular mechanisms responsible for the high anthocyanin content in Wufanshu berries.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Chemistry, Applied
Mingcong Fan, Tingting Li, Yan Li, Haifeng Qian, Hui Zhang, Zhiming Rao, Li Wang
Summary: Vaccinium bracteatum Thunb.(VBT) is well-known for its physiological and bioactivities, with potential health benefits in areas such as anti-diabetes, oxidative stress, and inflammation. However, its applications are currently limited to traditional foods and Chinese medicine, and further research and development are needed to explore its novel beneficial efficacy and applications.
Article
Biochemistry & Molecular Biology
Buyun Kim, Eun-Bin Kwon, Hye Jin Yang, Wei Li, Youn-Hwan Hwang, Young Soo Kim, Malk Eun Pak, Younghoon Go, Jang-Gi Choi
Summary: HSV-1 is a neurotropic virus that infects the peripheral and central nervous system. VBT, as Vaccinium bracteatum Thunb., shows anti-inflammatory, antioxidant, and antidiabetic activity. Research indicates that VBT has antiviral effects against HSV-1 infection.
Article
Engineering, Chemical
Dool-Ri Oh, Moon-Jong Kim, Eun-Jin Choi, Yujin Kim, Hak-Sung Lee, Donghyuck Bae, Chulyung Choi
Summary: The study found that p-coumaric acid from the water extract of Vaccinium bracteatum leaves protects against CORT-induced neurotoxicity by increasing CREB phosphorylation in neuronal cells.
Article
Food Science & Technology
Mingcong Fan, Zhengyu Bao, Tingting Li, Jiajia Zhao, Yan Li, Haifeng Qian, Hui Zhang, Zhiming Rao, Li Wang
Summary: This research evaluated the impact of the dark blue pigment from Vaccinium bracteatum Thunb. leaves on three digestive enzymes. The results showed that the pigment had a higher inhibition ability on alpha-glucosidase and had minimal impact on proteolytic enzyme activities. Molecular docking suggested the formation of hydrogen bonds and hydrophobic interactions between alpha-glucosidase and the pigment.
Article
Engineering, Chemical
Seul-Gi Lee, Haeju Ko, Eun-Jin Choi, Dool-Ri Oh, Donghyuck Bae, Chulyung Choi
Summary: In this study, a simple and rapid HPLC-based method was developed for the quantitative analysis of phytochemical compounds in Vaccinium bracteatum Thunb. leaf extract. Various compounds were identified in the VB extract, and the isolation of orientin and isoorientin validated the reverse-phase analytical method. The method was validated according to ICH guidelines, demonstrating excellent linearity, precision, and recovery values for orientin and isoorientin.
Article
Food Science & Technology
Xi Fu, Qing Liu, Enbo Xu, Yueyue Yang, Kunfu Zhu, Zhengyu Jin, Aiquan Jiao
Summary: The results demonstrate that the color and antioxidation properties of Vaccinium bracteatum Thunb. leaves (VBTL) remain stable during the wide-temperature extrusion process. Extrusion processing can be utilized to expand the usage of VBTL and streamline its traditional processing method. Applying VBTL to extrusion appears to be a suitable method for producing value-added extrudates with high antioxidant activity and low glycemic response.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Integrative & Complementary Medicine
Dool-Ri Oh, Yujin Kim, Sojeong Im, Kyo-Nyeo Oh, Jawon Shin, Changsik Jeong, Yonguk Kim, Eun Jin Choi, Chulyung Choi
Summary: The study demonstrated that VBL exerts neuroprotective effects against corticosterone or H2O2-induced cell death, improves spatial memory in CRS-exposed mice, and reduces acetylcholinesterase activity in the hippocampus and prefrontal cortex. Additionally, VBL decreased total Tau and Tau phosphorylation in the synapse of the hippocampus and prefrontal cortex, and reduced NMDA receptor subunits in CRS-exposed mice.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Haizhao Song, Xinchun Shen, Qiang Chu, Xiaodong Zheng
Summary: The polyphenol-rich extract from Vaccinium bracteatum Thunb. fruits showed significant effects in reducing obesity and obesity-related diseases by modulating the gut microbiota, leading to improvements in body weight gain, steatosis, and insulin resistance.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Chemistry, Applied
Mingcong Fan, Weijia Lian, Yan Li, Haifeng Qian, Hui Zhang, Zhiming Rao, Li Wang
Summary: This study investigates the effects of VBTL dark blue pigment on the physicochemical properties and in vitro digestibility of different rice starches. The results show that the addition of this pigment reduces the maximum starch digestion amount and increases the resistant starch in rice grains. These findings provide important evidence for the promotion of glycaemic regulation as a healthy cereal product.
Article
Food Science & Technology
Yingyun Peng, Han Jiang, Jinlong Zhang, Yufeng Wu, Jiehan Zhang, Zhou Jianhua, Yiyong Chen
Summary: In this study, a new polysaccharide VBTLP-2b was extracted and purified from Vaccinium bracteatum Thunb leaves. The synthesis process of VBTLP-2b-iron (III) complex was optimized, and its antioxidant activity was investigated. The results showed that VBTLP-2b-iron (III) exhibited better thermal stability and stronger antioxidant activities compared to VBTLP-2b, indicating its potential as a novel iron supplement.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2022)
Article
Materials Science, Textiles
Guangguo Tian, Rongrong Cui, Xiaorui Hu, Yan Feng
Summary: The leaves of Vaccinium bracteatum Thumb. are used to create vegetable dyes for dyeing cotton fabric, resulting in good dyeing effects and antibacterial properties. Pre-treatment with mordant and chitosan improved the dyeing and antibacterial properties of the fabric.
AATCC JOURNAL OF RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Giorgia Boero, Ryan E. Tyler, Todd K. O'Buckley, Irina Balan, Joyce Besheer, A. Leslie Morrow
Summary: This study found that 3 alpha,5 alpha-THP has different regulatory effects on stress response in male and female rats. 3 alpha,5 alpha-THP can reduce the increase of circulating corticosterone after stress and have different effects on the expression levels of hypothalamic CRF, CRFR1, CRFBP, POMC, and GR. These results suggest that gender differences and stress types play important roles in the regulation of the HPA axis by 3 alpha,5 alpha-THP.
Article
Psychology, Clinical
Jamie E. Mondello, Anny Gano, Andrew S. Vore, Terrence Deak
Summary: This study found that alcohol-associated cues can enhance the plasma corticosterone response to subthreshold alcohol dose and immune challenges, but not restraint challenges. These findings reveal that the impact of alcohol intoxication cues on the hypothalamic-pituitary-adrenal axis may be context-specific.
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
(2023)