Role of NADPH oxidase-2 in the progression of the inflammatory response secondary to striatum excitotoxic damage

Upregulation of NOX2 and NOX4 Mediated by TGF-β Signaling Pathway Exacerbates Cerebral Ischemia/Reperfusion Oxidative Stress Injury

(2018) Zheng Lou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Isoquercetin attenuates oxidative stress and neuronal apoptosis after ischemia/reperfusion injury via Nrf2-mediated inhibition of the NOX4/ROS/NF-κB pathway

(2018) Yunyi Dai et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Identification of glia phenotype modulators based on select glial function regulatory signaling pathways

(2018) Sun-Hwa Lee et al.   Expert Opinion on Drug Discovery

The dual role of ROS in autoimmune and inflammatory diseases: Evidence from preclinical models

(2018) Markus H. Hoffmann et al.   FREE RADICAL BIOLOGY AND MEDICINE

Involvement of Nox2 and Nox4 NADPH oxidases in early brain injury after subarachnoid hemorrhage

(2017) Li Zhang et al.   FREE RADICAL RESEARCH

Interleukin-10 inhibits neuroinflammation-mediated apoptosis of ventral mesencephalic neurons via JAK-STAT3 pathway

(2017) Yan Zhu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A combination antioxidant therapy to inhibit NOX2 and activate Nrf2 decreases secondary brain damage and improves functional recovery after traumatic brain injury

(2017) Raghavendar Chandran et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

N -methyl- d -aspartate receptor-mediated calcium overload and endoplasmic reticulum stress are involved in interleukin-1beta-induced neuronal apoptosis in rat hippocampus

(2017) Yilong Dong et al.   JOURNAL OF NEUROIMMUNOLOGY

Selective proliferative response of microglia to alternative polarization signals

(2017) Giovanna Pepe et al.   Journal of Neuroinflammation

NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for traumatic brain injury

(2017) James P. Barrett et al.   Journal of Neuroinflammation

Time courses of post-injury mitochondrial oxidative damage and respiratory dysfunction and neuronal cytoskeletal degradation in a rat model of focal traumatic brain injury

(2017) Rachel L. Hill et al.   NEUROCHEMISTRY INTERNATIONAL

NADPH Oxidase 2 Regulates NLRP3 Inflammasome Activation in the Brain after Traumatic Brain Injury

(2017) Merry W. Ma et al.   Oxidative Medicine and Cellular Longevity

Role of Interleukin-10 in Acute Brain Injuries

(2017) Joshua M. Garcia et al.   Frontiers in Neurology

Mesenchymal Stem Cells Overexpressing Interleukin-10 Promote Neuroprotection in Experimental Acute Ischemic Stroke

(2017) Masataka Nakajima et al.   Molecular Therapy-Methods & Clinical Development

NOX2 drives M1-like microglial/macrophage activation and neurodegeneration following experimental traumatic brain injury

(2016) Alok Kumar et al.   BRAIN BEHAVIOR AND IMMUNITY

Balancing the immune response in the brain: IL-10 and its regulation

(2016) Diogo Lobo-Silva et al.   Journal of Neuroinflammation

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Site-targeted complement inhibition by a complement receptor 2-conjugated inhibitor (mTT30) ameliorates post-injury neuropathology in mouse brains

(2016) Megan C. Rich et al.   NEUROSCIENCE LETTERS

NADPH oxidase promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in a cellular model of Parkinson’s disease

(2016) Rituraj Pal et al.   Scientific Reports

Call Off the Dog(ma): M1/M2 Polarization Is Concurrent following Traumatic Brain Injury

(2016) Josh M. Morganti et al.   PLoS One

Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor

(2015) Kazufumi Hirano et al.   ANTIOXIDANTS & REDOX SIGNALING

Macrophage activation and its role in repair and pathology after spinal cord injury

(2015) John C. Gensel et al.   BRAIN RESEARCH

Glutamate and GABA Imbalance Following Traumatic Brain Injury

(2015) Réjean M. Guerriero et al.   Current Neurology and Neuroscience Reports

Selective modulation of microglia polarization to M2 phenotype for stroke treatment

(2015) Cong-Yuan Xia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The anti-inflammatory activity of duloxetine, a serotonin/norepinephrine reuptake inhibitor, prevents kainic acid-induced hippocampal neuronal death in mice

(2015) Hee-Soo Choi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Clinical evidence of inflammation driving secondary brain injury

(2015) Holly E. Hinson et al.   Journal of Trauma and Acute Care Surgery

Neuroprotection of Ischemic Preconditioning is Mediated by Anti-inflammatory, Not Pro-inflammatory, Cytokines in the Gerbil Hippocampus Induced by a Subsequent Lethal Transient Cerebral Ischemia

(2015) Dong Won Kim et al.   NEUROCHEMICAL RESEARCH

Alternatively activated microglia and macrophages in the central nervous system

(2015) Rafael Franco et al.   PROGRESS IN NEUROBIOLOGY

Astroglia-Microglia Cross Talk during Neurodegeneration in the Rat Hippocampus

(2015) Montserrat Batlle et al.   Biomed Research International

Clinical evidence of inflammation driving secondary brain injury

(2015) Holly E. Hinson et al.   Journal of Trauma and Acute Care Surgery

Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance

(2014) Ana I. Rojo et al.   ANTIOXIDANTS & REDOX SIGNALING

Loss of NADPH Oxidase–Derived Superoxide Skews Macrophage Phenotypes to Delay Type 1 Diabetes

(2014) Lindsey E. Padgett et al.   DIABETES

Characterization of the expression and inflammatory activity of NADPH oxidase after spinal cord injury

(2014) S. J. Cooney et al.   FREE RADICAL RESEARCH

IL-4 type 1 receptor signaling up-regulates KCNN4 expression, and increases the KCa3.1 current and its contribution to migration of alternative-activated microglia

(2014) Roger Ferreira et al.   Frontiers in Cellular Neuroscience

Redox Control of Inflammation in Macrophages

(2013) Bernhard Brüne et al.   ANTIOXIDANTS & REDOX SIGNALING

Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro

(2013) Vibol Chhor et al.   BRAIN BEHAVIOR AND IMMUNITY

NOX2 deficiency ameliorates cerebral injury through reduction of complexin II-mediated glutamate excitotoxicity in experimental stroke

(2013) Ziying Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Calpain activation induced by glucose deprivation is mediated by oxidative stress and contributes to neuronal damage

(2013) Blanca Páramo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation

(2013) M. E. Heid et al.   JOURNAL OF IMMUNOLOGY

Neuroinflammation: The role and consequences

(2013) Monty Lyman et al.   NEUROSCIENCE RESEARCH

Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies

(2013) Gaia Codolo et al.   PLoS One

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

(2013) Ted Weita Lai et al.   PROGRESS IN NEUROBIOLOGY

NADPH oxidases as therapeutic targets in ischemic stroke

(2012) Timo Kahles et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The NOX toolbox: validating the role of NADPH oxidases in physiology and disease

(2012) Sebastian Altenhöfer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS

(2012) Bing Liao et al.   EXPERIMENTAL NEUROLOGY

Neuroprotective function for ramified microglia in hippocampal excitotoxicity

(2012) Jonathan Vinet et al.   Journal of Neuroinflammation

Dissection and Culture of Mouse Dopaminergic and Striatal Explants in Three-Dimensional Collagen Matrix Assays

(2012) Ewoud R.E. Schmidt et al.   Jove-Journal of Visualized Experiments

Activation of NOX2 by the Stimulation of Ionotropic and Metabotropic Glutamate Receptors Contributes to Glutamate Neurotoxicity In Vivo Through the Production of Reactive Oxygen Species and Calpain Activation

(2011) Alicia Guemez-Gamboa et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease

(2010) F. Meissner et al.   BLOOD

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration

(2010) Joanna Mikita et al.   Multiple Sclerosis Journal

NOX2 mediates apoptotic death induced by staurosporine but not by potassium deprivation in cerebellar granule neurons

(2009) Alicia Guemez-Gamboa et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Apoptosis and autophagy in rat cerebellar granule neuron death: Role of reactive oxygen species

(2009) Paola Maycotte et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The adhesive removal test: a sensitive method to assess sensorimotor deficits in mice

(2009) Valentine Bouet et al.   Nature Protocols

Glutamate toxicity in the striatum of the R6/2 Huntington's disease transgenic mice is age-dependent and correlates with decreased levels of glutamate transporters

(2009) Ana María Estrada-Sánchez et al.   NEUROBIOLOGY OF DISEASE

Role of NADPH oxidase in the apoptotic death of cultured cerebellar granule neurons

(2008) Angélica Coyoy et al.   FREE RADICAL BIOLOGY AND MEDICINE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE