A combination antioxidant therapy to inhibit NOX2 and activate Nrf2 decreases secondary brain damage and improves functional recovery after traumatic brain injury

Sulforaphane improves outcomes and slows cerebral ischemic/reperfusion injury via inhibition of NLRP3 inflammasome activation in rats

(2017) Chang Yu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

NADPH oxidase in brain injury and neurodegenerative disorders

(2017) Merry W. Ma et al.   Molecular Neurodegeneration

NOX2 drives M1-like microglial/macrophage activation and neurodegeneration following experimental traumatic brain injury

(2016) Alok Kumar et al.   BRAIN BEHAVIOR AND IMMUNITY

Post-Injury Administration of Tert-butylhydroquinone Attenuates Acute Neurological Injury After Intracerebral Hemorrhage in Mice

(2016) Sangeetha Sukumari-Ramesh et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Poststroke Induction of  -Synuclein Mediates Ischemic Brain Damage

(2016) T. Kim et al.   JOURNAL OF NEUROSCIENCE

Performance of Male and Female C57BL/6J Mice on Motor and Cognitive Tasks Commonly Used in Pre-Clinical Traumatic Brain Injury Research

(2016) Laura B. Tucker et al.   JOURNAL OF NEUROTRAUMA

Nrf2 Weaves an Elaborate Network of Neuroprotection Against Stroke

(2016) Shuai Jiang et al.   MOLECULAR NEUROBIOLOGY

The Controlled Cortical Impact Model: Applications, Considerations for Researchers, and Future Directions

(2016) Nicole D. Osier et al.   Frontiers in Neurology

NOX2 As a Target for Drug Development: Indications, Possible Complications, and Progress

(2015) Becky A. Diebold et al.   ANTIOXIDANTS & REDOX SIGNALING

Traumatic Brain Injury and NADPH Oxidase: A Deep Relationship

(2015) Cristina Angeloni et al.   Oxidative Medicine and Cellular Longevity

Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease

(2014) Stewart Siyan Cao et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative Stress in Traumatic Brain Injury

(2014) Ana Rodriguez-Rodriguez et al.   CURRENT MEDICINAL CHEMISTRY

Suppression of Oxidative Stress and 5-Lipoxygenase Activation by Edaravone Improves Depressive-Like Behavior after Concussion

(2014) Youichirou Higashi et al.   JOURNAL OF NEUROTRAUMA

Interactions of Oxidative Stress and Neurovascular Inflammation in the Pathogenesis of Traumatic Brain Injury

(2014) P. M. Abdul-Muneer et al.   MOLECULAR NEUROBIOLOGY

NADPH oxidase inhibition improves neurological outcome in experimental traumatic brain injury

(2014) Xin-Yu Lu et al.   NEUROCHEMISTRY INTERNATIONAL

A Molecular Web: Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress

(2014) Namrata Chaudhari et al.   Frontiers in Cellular Neuroscience

Traumatic Brain Injury: Oxidative Stress and Neuroprotection

(2013) Carolin Cornelius et al.   ANTIOXIDANTS & REDOX SIGNALING

TrkB Receptor Agonist 7, 8 Dihydroxyflavone Triggers Profound Gender- Dependent Neuroprotection in Mice After Perinatal Hypoxia and Ischemia

(2013) Kutluay Uluc et al.   CNS & Neurological Disorders-Drug Targets

Pretreatment with tert-butylhydroquinone attenuates cerebral oxidative stress in mice after traumatic brain injury

(2013) Xin-Yu Lu et al.   JOURNAL OF SURGICAL RESEARCH

Changing patterns in the epidemiology of traumatic brain injury

(2013) Bob Roozenbeek et al.   Nature Reviews Neurology

The effect of NADPH-oxidase inhibitor apocynin on cognitive impairment induced by moderate lateral fluid percussion injury: Role of inflammatory and oxidative brain damage

(2013) Ana Paula Oliveira Ferreira et al.   NEUROCHEMISTRY INTERNATIONAL

Prevention of traumatic brain injury-induced neuronal death by inhibition of NADPH oxidase activation

(2012) Bo Yong Choi et al.   BRAIN RESEARCH

Apocynin reduces reactive oxygen species concentrations in exhaled breath condensate in asthmatics

(2012) J. Stefanska et al.   EXPERIMENTAL LUNG RESEARCH

Activation of mGluR5 and Inhibition of NADPH Oxidase Improves Functional Recovery after Traumatic Brain Injury

(2012) David J. Loane et al.   JOURNAL OF NEUROTRAUMA

Attenuation of brain edema and spatial learning deficits by the inhibition of NADPH oxidase activity using apocynin following diffuse traumatic brain injury in rats

(2012) SI-XIN SONG et al.   Molecular Medicine Reports

Critical Role of NADPH Oxidase in Neuronal Oxidative Damage and Microglia Activation following Traumatic Brain Injury

(2012) Quan-Guang Zhang et al.   PLoS One

Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection

(2012) Meijuan Zhang et al.   PROGRESS IN NEUROBIOLOGY

Chronic Neurological Deficits in Mice after Perinatal Hypoxia and Ischemia Correlate with Hemispheric Tissue Loss and White Matter Injury Detected by MRI

(2011) Pelin Cengiz et al.   DEVELOPMENTAL NEUROSCIENCE

Activation of NOX2 by the Stimulation of Ionotropic and Metabotropic Glutamate Receptors Contributes to Glutamate Neurotoxicity In Vivo Through the Production of Reactive Oxygen Species and Calpain Activation

(2011) Alicia Guemez-Gamboa et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Modulation of Transcription Factor Nrf2 in an In Vitro Model of Traumatic Brain Injury

(2011) Haris Hatic et al.   JOURNAL OF NEUROTRAUMA

Effects of Tert-Butylhydroquinone on Intestinal Inflammatory Response and Apoptosis following Traumatic Brain Injury in Mice

(2011) Wei Jin et al.   MEDIATORS OF INFLAMMATION

NADPH oxidase-mediated oxidative damage to proteins in the postsynaptic density after transient cerebral ischemia and reperfusion

(2011) Kazutoshi Murotomi et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Inhibition of Na+/H+ Exchanger Isoform 1 Is Neuroprotective in Neonatal Hypoxic Ischemic Brain Injury

(2010) Pelin Cengiz et al.   ANTIOXIDANTS & REDOX SIGNALING

Modulation of NADPH oxidase activation in cerebral ischemia/reperfusion injury in rats

(2010) Tiziana Genovese et al.   BRAIN RESEARCH

Oxidative stress targets in pulmonary emphysema: focus on the Nrf2 pathway

(2010) A Boutten et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury

(2010) Kenji Dohi et al.   Journal of Neuroinflammation

Antioxidant therapies for traumatic brain injury

(2010) Edward D. Hall et al.   Neurotherapeutics

Reduction of cerebral infarct volume by apocynin requires pretreatment and is absent in Nox2-deficient mice

(2009) KA Jackman et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeting the Nrf2 pathway against cardiovascular disease

(2009) Jinqing Li et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Inhibition of NADPH Oxidase is Neuroprotective after Ischemia—Reperfusion

(2009) Hai Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Structural Insights into Nox4 and Nox2: Motifs Involved in Function and Cellular Localization

(2009) K. von Lohneysen et al.   MOLECULAR AND CELLULAR BIOLOGY

Reactive oxygen species are NOXious for neurons

(2009) Nicolas Demaurex et al.   NATURE NEUROSCIENCE

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

(2009) Angela M Brennan et al.   NATURE NEUROSCIENCE

Sulforaphane improves cognitive function administered following traumatic brain injury

(2009) Pramod K. Dash et al.   NEUROSCIENCE LETTERS

The Nrf2/ARE Pathway as a Potential Therapeutic Target in Neurodegenerative Disease

(2008) Marcus J. Calkins et al.   ANTIOXIDANTS & REDOX SIGNALING

Nox4 and Nox2 NADPH Oxidases Mediate Distinct Cellular Redox Signaling Responses to Agonist Stimulation

(2008) Narayana Anilkumar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

PPARγ agonist rosiglitazone is neuroprotective after traumatic brain injury via anti-inflammatory and anti-oxidative mechanisms

(2008) Jae-Hyuk Yi et al.   BRAIN RESEARCH

Role of NADPH oxidase in the apoptotic death of cultured cerebellar granule neurons

(2008) Angélica Coyoy et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Time Course of Contusion-Induced Oxidative Stress and Synaptic Proteins in Cortex in a Rat Model of TBI

(2008) Mubeen A. Ansari et al.   JOURNAL OF NEUROTRAUMA

Apocynin: Molecular Aptitudes

(2008) J. Stefanska et al.   MEDIATORS OF INFLAMMATION

Apocynin improves outcome in experimental stroke with a narrow dose range

(2008) X.N. Tang et al.   NEUROSCIENCE

Activation of Nrf2–ARE pathway in brain after traumatic brain injury

(2008) Wei Yan et al.   NEUROSCIENCE LETTERS