Microglia activation induces oxidative injury and decreases SIRT3 expression in dopaminergic neuronal cells

NAD+-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole-body metabolism

(2018) Lane C Porter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Evidence supporting a mechanistic role of sirtuins in mood and metabolic disorders

(2018) Asem Alageel et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Renal mitochondrial oxidative stress is enhanced by the reduction of Sirt3 activity, in Zucker diabetic fatty rats

(2018) Yoshio Ogura et al.   REDOX REPORT

Sirt3 Ameliorates Oxidative Stress and Mitochondrial Dysfunction After Intracerebral Hemorrhage in Diabetic Rats

(2018) Jingwei Zheng et al.   Frontiers in Neuroscience

S-nitrosylation of divalent metal transporter 1 enhances iron uptake to mediate loss of dopaminergic neurons and motoric deficit

(2018) Chao Liu et al.   JOURNAL OF NEUROSCIENCE

Sirt3 attenuates post-infarction cardiac injury via inhibiting mitochondrial fission and normalization of AMPK-Drp1 pathways

(2018) Jixuan Liu et al.   CELLULAR SIGNALLING

Knockdown of cathepsin D protects dopaminergic neurons against neuroinflammation-mediated neurotoxicity through inhibition of NF-κB signalling pathway in Parkinson's disease model

(2018) Ping Gan et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

An overview of Sirtuins as potential therapeutic target: Structure, function and modulators

(2018) Yijie Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease

(2018) Irene García-Domínguez et al.   Frontiers in Cellular Neuroscience

Sirt3 protects dopaminergic neurons from mitochondrial oxidative stress

(2017) Han Shi et al.   HUMAN MOLECULAR GENETICS

Licochalcone A Prevents the Loss of Dopaminergic Neurons by Inhibiting Microglial Activation in Lipopolysaccharide (LPS)-Induced Parkinson’s Disease Models

(2017) Bingxu Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of autophagy in pro-inflammatory responses of microglia activation via mitochondrial reactive oxygen species in vitro

(2017) Junli Ye et al.   JOURNAL OF NEUROCHEMISTRY

SIRT3 in Neural Stem Cells Attenuates Microglia Activation-Induced Oxidative Stress Injury Through Mitochondrial Pathway

(2017) De-Qi Jiang et al.   Frontiers in Cellular Neuroscience

SIRT3 protects hepatocytes from oxidative injury by enhancing ROS scavenging and mitochondrial integrity

(2017) Jingxin Liu et al.   Cell Death & Disease

Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and Parkinson's disease

(2017) Gargi Ganguly et al.   Drug Design Development and Therapy

Oxidative stress and cellular pathologies in Parkinson’s disease

(2017) Lesly Puspita et al.   Molecular Brain

PGC-1α/ERRα-Sirt3 Pathway Regulates DAergic Neuronal Death by Directly Deacetylating SOD2 and ATP Synthase β

(2016) Xuefei Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Electron transport chain inhibitors induce microglia activation through enhancing mitochondrial reactive oxygen species production

(2016) Junli Ye et al.   EXPERIMENTAL CELL RESEARCH

N-Adamantyl-4-methylthiazol-2-amine suppresses amyloid β-induced neuronal oxidative damage in cortical neurons

(2016) Chang Hun Cho et al.   FREE RADICAL RESEARCH

SIRT3 participates in glucose metabolism interruption and apoptosis induced by BH3 mimetic S1 in ovarian cancer cells

(2016) Xi-Yan Xiang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Loss of Fatty Acid Binding Protein 4/aP2 Reduces Macrophage Inflammation Through Activation of SIRT3

(2016) Hongliang Xu et al.   MOLECULAR ENDOCRINOLOGY

LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathways

(2016) Heng Zeng et al.   Scientific Reports

Overexpression of mitochondrial Hsp75 protects neural stem cells against microglia-derived soluble factor-induced neurotoxicity by regulating mitochondrial permeability transition pore opening in vitro

(2015) YAN WANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Nicotine contributes to the neural stem cells fate against toxicity of microglial-derived factors induced by Aβ via the Wnt/β-catenin pathway

(2015) De-Qi Jiang et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

SIRT3 Attenuates MPTP-Induced Nigrostriatal Degeneration Via Enhancing Mitochondrial Antioxidant Capacity

(2015) Lei Liu et al.   NEUROCHEMICAL RESEARCH

Adjudin protects rodent cochlear hair cells against gentamicin ototoxicity via the SIRT3-ROS pathway

(2015) Yizhou Quan et al.   Scientific Reports

Decreased SIRT3 in aged human mesenchymal stromal/stem cells increases cellular susceptibility to oxidative stress

(2014) Xue-Qing Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Age-Related Decrease in the Mitochondrial Sirtuin Deacetylase Sirt3 Expression Associated with ROS Accumulation in the Auditory Cortex of the Mimetic Aging Rat Model

(2014) Lingling Zeng et al.   PLoS One

Protective Effects of Astragaloside IV against Amyloid Beta1-42 Neurotoxicity by Inhibiting the Mitochondrial Permeability Transition Pore Opening

(2014) Qinru Sun et al.   PLoS One

Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity

(2013) Alexander R. Moschen et al.   JOURNAL OF HEPATOLOGY

Tetrahydroxystilbene Glucoside Attenuates Neuroinflammation through the Inhibition of Microglia Activation

(2013) Feng Zhang et al.   Oxidative Medicine and Cellular Longevity

Etiology and pathogenesis of Parkinson's disease

(2011) Anthony H. Schapira et al.   MOVEMENT DISORDERS

Inhibition of mitochondrial permeability transition pore opening is involved in the protective effects of mortalin overexpression against beta-amyloid-induced apoptosis in SH-SY5Y cells

(2011) Mingyue Qu et al.   NEUROSCIENCE RESEARCH

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Catalpol attenuates the neurotoxicity induced by β-amyloid1–42 in cortical neuron–glia cultures

(2007) Bo Jiang et al.   BRAIN RESEARCH