LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathways

SIRT3: Striking at the heart of aging

(2016) Yufei Liu et al.   Aging-US

Thymosin β4 attenuates microcirculatory and hemodynamic destabilization in sepsis

(2015) Dario Bongiovanni et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss

(2015) Heng Zeng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Conditional Knockout of Prolyl Hydroxylase Domain Protein 2 Attenuates High Fat-Diet-Induced Cardiac Dysfunction in Mice

(2014) Heng Zeng et al.   PLoS One

Notch3 establishes brain vascular integrity by regulating pericyte number

(2013) Y. Wang et al.   DEVELOPMENT

Apelin Inhibits Diet-Induced Obesity by Enhancing Lymphatic and Blood Vessel Integrity

(2013) M. Sawane et al.   DIABETES

Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis

(2013) Tilman Ziegler et al.   JOURNAL OF CLINICAL INVESTIGATION

Myocardial Injection of Apelin-Overexpressing Bone Marrow Cells Improves Cardiac Repair via Upregulation of Sirt3 after Myocardial Infarction

(2013) Lanfang Li et al.   PLoS One

Abl Family Kinases Regulate Endothelial Barrier Function In Vitro and in Mice

(2013) Elizabeth M. Chislock et al.   PLoS One

Coronary Microvascular Pericytes Are the Cellular Target of Sunitinib Malate-Induced Cardiotoxicity

(2013) V. Chintalgattu et al.   Science Translational Medicine

Emerging therapeutic strategies to prevent infection-related microvascular endothelial activation and dysfunction

(2013) Ilyse Darwish et al.   Virulence

Dysregulation of the angiopoietin–Tie-2 axis in sepsis and ARDS

(2013) Samir M Parikh   Virulence

SIRT3 Weighs Heavily in the Metabolic Balance: A New Role for SIRT3 in Metabolic Syndrome

(2012) M. F. Green et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Ultrastructural Changes in Cerebral Capillary Pericytes in Aged Notch3 Mutant Transgenic Mice

(2012) Xin Gu et al.   ULTRASTRUCTURAL PATHOLOGY

Notch3 Is Essential for Regulation of the Renal Vascular Tone

(2011) Nada Boulos et al.   HYPERTENSION

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

Broken Barriers: A New Take on Sepsis Pathogenesis

(2011) N. M. Goldenberg et al.   Science Translational Medicine

Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia

(2010) H. Kidoya et al.   BLOOD

Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis

(2009) Konstantin Gaengel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

ANGIOPOIETIN-1 IN THE TREATMENT OF ISCHEMIA AND SEPSIS

(2009) Nathan M. Novotny et al.   SHOCK

Regulation of angiopoietin expression by bacterial lipopolysaccharide

(2008) Mahroo Mofarrahi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Detachment of Brain Pericytes from the Basal Lamina is Involved in Disruption of the Blood–Brain Barrier Caused by Lipopolysaccharide-Induced Sepsis in Mice

(2008) Tsuyoshi Nishioku et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Ang-1 Gene Therapy Inhibits Hypoxia-Inducible Factor-1  (HIF-1 )-Prolyl-4-Hydroxylase-2, Stabilizes HIF-1  Expression, and Normalizes Immature Vasculature in db/db Mice

(2008) J.-X. Chen et al.   DIABETES

Sphingosine 1-phosphate rescues canine LPS-induced acute lung injury and alters systemic inflammatory cytokine production in vivo

(2008) William S. Szczepaniak et al.   Translational Research