Protective Effects of Astragaloside IV against Amyloid Beta1-42 Neurotoxicity by Inhibiting the Mitochondrial Permeability Transition Pore Opening

Neuron Specific Toxicity of Oligomeric Amyloid-β: Role for JUN-Kinase and Oxidative Stress

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Cyclophilin D Deficiency Rescues Axonal Mitochondrial Transport in Alzheimer’s Neurons

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Stabilizers of Neuronal and Mitochondrial Calcium Cycling as a Strategy for Developing a Medicine for Alzheimer's Disease

(2012) José-Carlos Fernández-Morales et al.   ACS Chemical Neuroscience

Interleukin-13/-4-Induced Oxidative Stress Contributes to Death of Hippocampal Neurons in Aβ1-42-Treated Hippocampus In Vivo

(2012) J.H. Nam et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondria, oxidative stress and neurodegeneration

(2012) Antonio Federico et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Astragaloside IV prevents MPP+-induced SH-SY5Y cell death via the inhibition of Bax-mediated pathways and ROS production

(2012) Zhi-guo Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

Deciphering the mechanism underlying late-onset Alzheimer disease

(2012) Dimitrije Krstic et al.   Nature Reviews Neurology

Astragaloside IV Alleviates Hypoxia/Reoxygenation-Induced Neonatal Rat Cardiomyocyte Injury via the Protein Kinase A Pathway

(2012) Da-Wei Zhang et al.   PHARMACOLOGY

Diammonium Glycyrrhizinate Upregulates PGC-1α and Protects against Aβ1–42-Induced Neurotoxicity

(2012) Xiaolei Zhu et al.   PLoS One

Blockade of electron transport during ischemia preserves bcl-2 and inhibits opening of the mitochondrial permeability transition pore

(2011) Qun Chen et al.   FEBS LETTERS

Effect of β-amyloid (25-35) on mitochondrial function and expression of mitochondrial permeability transition pore proteins in rat hippocampal neurons

(2011) Rui Ren et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Astragaloside IV Improves Metabolic Syndrome and Endothelium Dysfunction in Fructose-Fed Rats

(2011) Ning Zhang et al.   MOLECULES

Inhibition of mitochondrial permeability transition pore opening is involved in the protective effects of mortalin overexpression against beta-amyloid-induced apoptosis in SH-SY5Y cells

(2011) Mingyue Qu et al.   NEUROSCIENCE RESEARCH

BAX insertion, oligomerization, and outer membrane permeabilization in brain mitochondria: Role of permeability transition and SH-redox regulation

(2010) Tatiana Brustovetsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Neuroprotective effects of emodin in rat cortical neurons against β-amyloid-induced neurotoxicity

(2010) Tao Liu et al.   BRAIN RESEARCH

Amyloid β1–42 oligomer inhibits myelin sheet formation in vitro

(2010) Makoto Horiuchi et al.   NEUROBIOLOGY OF AGING

Triterpenoid saponins from Astragalus wiedemannianus Fischer

(2010) Emre Polat et al.   PHYTOCHEMISTRY

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

(2010) H. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the Mitochondrion in Programmed Necrosis

(2010) Christopher P. Baines   Frontiers in Physiology

The role of the mitochondrial permeability transition pore in heart disease

(2009) Andrew P. Halestrap et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta

(2009) Heng Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Alzheimer's disease: a global challenge for the 21st century

(2009) Jean François Dartigues   LANCET NEUROLOGY

Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model

(2009) Heng Du et al.   NEUROBIOLOGY OF AGING

Neuroprotective effects of Astragaloside IV in 6-hydroxydopamine-treated primary nigral cell culture

(2009) Wing-Sai Chan et al.   NEUROCHEMISTRY INTERNATIONAL

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE