N-Adamantyl-4-methylthiazol-2-amine suppresses amyloid β-induced neuronal oxidative damage in cortical neurons

Oxidative Balance in Alzheimer's Disease: Relationship to APOE, Braak Tangle Stage, and the Concentrations of Soluble and Insoluble Amyloid-β

(2017) Hannah Tayler et al.   JOURNAL OF ALZHEIMERS DISEASE

One-step isolation of sappanol and brazilin from Caesalpinia sappan and their effects on oxidative stress-induced retinal death

(2015) Golam Mezbah Uddin et al.   BMB Reports

Anticancer activity of CopA3 dimer peptide in human gastric cancer cells

(2015) Joon Ha Lee et al.   BMB Reports

Effect of respiratory syncytial virus on the growth of hepatocellular carcinoma cell-lines

(2015) Song Hee Choi et al.   BMB Reports

Celastrol ameliorates cytokine toxicity and pro-inflammatory immune responses by suppressing NF-κB activation in RINm5F beta cells

(2015) Sung Mi Ju et al.   BMB Reports

Amyloid β25–35 induced ROS-burst through NADPH oxidase is sensitive to iron chelation in microglial Bv2 cells

(2015) Kristin Part et al.   BRAIN RESEARCH

Salicortin suppresses lipopolysaccharide-stimulated inflammatory responses via blockade of NF-κB and JNK activation in RAW 264.7 macrophages

(2014) Dong-Joo Kwon et al.   BMB Reports

BI-1 enhances Fas-induced cell death through a Na+/H+-associated mechanism

(2014) Geum-Hwa Lee et al.   BMB Reports

PEP-1-HO-1 prevents MPTP-induced degeneration of dopaminergic neurons in a Parkinson's disease mouse model

(2014) Jong Kyu Youn et al.   BMB Reports

Effects of N-adamantyl-4-methylthiazol-2-amine on hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats

(2014) Seung-Ju Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anti-inflammatory mechanisms of N-adamantyl-4-methylthiazol-2-amine in lipopolysaccharide-stimulated BV-2 microglial cells

(2014) Eun-A Kim et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

2-Aminothiazoles with Improved Pharmacotherapeutic Properties for Treatment of Prion Disease

(2013) Zhe Li et al.   ChemMedChem

Nicotinamide treatment reduces the levels of oxidative stress, apoptosis, and PARP-1 activity in Aβ(1–42)-induced rat model of Alzheimer's disease

(2013) E. Turunc Bayrakdar et al.   FREE RADICAL RESEARCH

Anti-oxidative and anti-inflammatory effects of 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride on glutamate-induced neurotoxicity in rat brain

(2013) Eun-A Kim et al.   NEUROTOXICOLOGY

PARP-1 Modulates Amyloid Beta Peptide-Induced Neuronal Damage

(2013) Sara Martire et al.   PLoS One

Novel S-acyl glutathione derivatives prevent amyloid oxidative stress and cholinergic dysfunction in Alzheimer disease models

(2012) Mariagioia Zampagni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal cultures from rat hippocampus: involvement of the GSK-3β/Nrf2 signaling pathway

(2012) Y. Zou et al.   FREE RADICAL RESEARCH

Liberation of Copper from Amyloid Plaques: Making a Risk Factor Useful for Alzheimer’s Disease Treatment

(2012) Jie Geng et al.   JOURNAL OF MEDICINAL CHEMISTRY

O-linked β-N-acetylglucosaminidase inhibitor attenuates β-amyloid plaque and rescues memory impairment

(2012) Chaeyoung Kim et al.   NEUROBIOLOGY OF AGING

Rutin inhibits β-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines

(2012) Shao-wei Wang et al.   NEUROTOXICOLOGY

2-Aminothiazoles as Therapeutic Leads for Prion Diseases

(2011) Alejandra Gallardo-Godoy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular mechanism of Thioflavin-T binding to amyloid fibrils

(2010) Matthew Biancalana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

β-Amyloid peptide increases levels of iron content and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease

(2010) Li Wan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Comparable Attenuation of Aβ25–35-Induced Neurotoxicity by Quercitrin and 17β-Estradiol in Cultured Rat Hippocampal Neurons

(2010) Sadudee Rattanajarasroj et al.   NEUROCHEMICAL RESEARCH

NOX Activity Is Increased in Mild Cognitive Impairment

(2009) Annadora J. Bruce-Keller et al.   ANTIOXIDANTS & REDOX SIGNALING

The unsolved relationship of brain aging and late-onset Alzheimer disease

(2009) Andreas Kern et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Novel Orally Bioavailable γ-Secretase Inhibitors with Excellent in Vivo Activity

(2009) Linda E. Keown et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of Amidine, Guanidine, and Thiourea Derivatives of 2-Amino(6-trifluoromethoxy)benzothiazole as Neuroprotective Agents Potentially Useful in Brain Diseases

(2009) Maurizio Anzini et al.   JOURNAL OF MEDICINAL CHEMISTRY

KNS-760704 [(6R)-4,5,6,7-tetrahydro-N6-propyl-2, 6-benzothiazole-diamine dihydrochloride monohydrate] for the Treatment of Amyotrophic Lateral Sclerosis

(2008) Valentin K. Gribkoff et al.   CNS Neuroscience & Therapeutics

Structure-Function Implications in Alzheimers Disease: Effect of Aβ Oligomers at Central Synapses

(2008) Waldo Cerpa et al.   Current Alzheimer Research

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

(2008) Rosa Resende et al.   FREE RADICAL BIOLOGY AND MEDICINE

Panaxydol and panaxynol protect cultured cortical neurons against Aβ25–35-induced toxicity

(2008) Bao-Ming Nie et al.   NEUROPHARMACOLOGY

Thioflavin Derivatives as Markers for Amyloid-β Fibrils: Insights into Structural Features Important for High-Affinity Binding

(2007) Rodrigue Leuma Yona et al.   ChemMedChem